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UCB Presents Growing Body of Long-term Efficacy Data at ACG 2010 Meeting to Further Support Treatment with Cimzia® (certolizumab pegol) in Multiple Patient Populations with Moderate to Severe Crohn's Disease
Date:10/18/2010

these disorders.

Hematologic ReactionsRare reports of pancytopenia, including aplastic anemia, have been reported with TNF blockers.  Medically significant cytopenia (e.g., leukopenia, pancytopenia, thrombocytopenia) has been infrequently reported with CIMZIA.  Advise all patients to seek immediate medical attention if they develop signs and symptoms suggestive of blood dyscrasias or infection (e.g., persistent fever, bruising, bleeding, pallor) while on CIMZIA.  Consider discontinuation of CIMZIA therapy in patients with confirmed significant hematologic abnormalities.

Drug InteractionsAn increased risk of serious infections has been seen in clinical trials of other TNF blocking agents used in combination with anakinra or abatacept.  Formal drug interaction studies have not been performed with rituximab or natalizumab; however because of the nature of the adverse events seen with these combinations with TNF blocker therapy, similar toxicities may also result from the use of CIMZIA in these combinations.  Therefore, the combination of CIMZIA with anakinra, abatcept, rituximab or natalizumab is not recommended.  Interference with certain coagulation assays has been detected in patients treated with CIMZIA.  There is no evidence that CIMZIA therapy has an effect on in vivo coagulation.  CIMZIA may cause erroneously elevated aPTT assay results in patients without coagulation abnormalities.

AutoimmunityTreatment with CIMZIA may result in the formation of autoantibodies and, rarely, in the development of a lupus-like syndrome.  Discontinue treatment if symptoms of lupus-like syndrome develop.

ImmunizationsDo not administer live vaccines or attenuated vaccines concurrently with CIMZIA.

Adverse ReactionsIn controlled Crohn's clinical trials, the most common adverse events that occurred in greater than or equal to 5% of CIMZIA patients (n=620) and more frequently than w
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