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U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant
Date:11/6/2008

: DEN-1, DEN-2, DEN-3 and DEN-4. These viruses are part of the Flavivirus family, which includes West Nile virus and yellow fever virus. Dengue virus is spread by mosquitoes, and is most common during the rainy seasons throughout the world's tropical and subtropical regions. Dengue does not spread directly from person to person. An individual infected by one serotype of dengue virus develops lifelong immunity against that serotype, but not against other serotypes.

Symptoms of classic dengue fever include high fever (up to 105 degrees F), severe headache and/or pain behind the eyes, severe joint and muscle pain, nausea and vomiting. A few days after fever onset, a rash often develops over most of the body and lasts for one to two days. The rash can reappear several days later. These symptoms typically begin within a week after infection, and usually resolve without treatment.

Dengue hemorrhagic fever is a more serious form of disease which can include all of the symptoms of classic dengue fever plus noticeable damage to blood vessels and lymph vessels, bleeding from the nose and gums, and conspicuous bruising under the skin. Dengue hemorrhagic fever can lead to death. The most severe form of dengue disease is dengue shock syndrome, which includes all of the symptoms of classic dengue and dengue hemorrhagic fever, plus leaking of blood outside of blood vessels, extensive bleeding, and shock caused by extremely low blood pressure. Dengue shock syndrome most often occurs in children infected for a second time (with a different serotype of dengue), and can be fatal. Dengue disease, including classic dengue, dengue hemorrhagic fever and dengue shock syndrome, is increasing in both incidence and severity throughout many tropical regions of the world, especially in Africa, the Indian subcontinent, and Southeast Asia.

NMRC Dengue Focus

The Naval Medical Research Center conducts research into the many health threats to members of the U.S. military.
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