Navigation Links
U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant
Date:11/6/2008

delivered with the Biojector(R) 2000 needle-free injection system. Preliminary results indicated that the vaccine was safe and well-tolerated at both the 1 mg low dose and 5 mg high dose tested, but even at the high dose induced only low levels of neutralizing antibody titers in less than half of the animals. Under a Collaborative Research and Development Agreement (CRADA) with Vical, the NMRC developed a tetravalent dengue vaccine containing prM and E genes for all four serotypes of dengue, and formulated with the Vaxfectin(R) adjuvant. Nonhuman primate immunogenicity and challenge data with the tetravalent DNA vaccine, formulated with or without the Vaxfectin(R) adjuvant and delivered by needle-free injection using the Biojector(R) 2000, were promising.

Four of four (100%) rhesus macaques receiving the Vaxfectin(R)-formulated vaccine developed neutralizing antibodies to all four serotypes of dengue one month after the second injection (Day 56), and were highly protected against challenge, exhibiting very limited viremia (group mean 0.75 days). Only one of four (25%) macaques receiving the unformulated vaccine developed neutralizing antibodies to all four serotypes of dengue one month after the second injection (Day 56), and were partially protected against challenge, exhibiting limited viremia (group mean 2.00 days). The unvaccinated control macaques did not develop any neutralizing antibodies, and were unprotected against challenge, exhibiting typical viremia (group mean 3.33 days). The next step in this program will be to advance this vaccine to Phase 1 human testing.

About Dengue

Dengue virus infects up to 100 million people each year. Its impact is magnified by the lack of effective antiviral drugs and vaccines. As many as half a million people develop severe dengue disease each year, causing tens of thousands of deaths, particularly where healthcare is limited.

Dengue fever can be caused by any one of four serotypes of dengue virus
'/>"/>

SOURCE Vical Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. EpiCept Reports Expansion of Clinical Development For Licensed Cancer Compound
2. Promising Cystic Fibrosis Compound on Track for Development
3. Vical Reports Second Quarter 2007 Financial Results, Allowance of Pandemic Influenza IND and Other Advances in Product Development Programs
4. CuraGen Provides Update on Velafermin, Belinostat and CR011-vcMMAE Clinical Development Programs
5. Sarasotas Roskamp Institute Releases Study Defining a Mechanism for Development of Obesity and the Metabolic Syndrome, Forerunners of Type 2 Diabetes
6. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
7. Saving Lives of California Residents Who Develop Skin Cancer Each Year: The Key is Early Detection and Treatment
8. New Company Starts, Bridging the Development Gap in the Discovery of Cancer Drugs
9. Quest Diagnostics Introduces ClariSure(TM) Test for Identifying Chromosome Abnormalities Associated With 85 Developmental Disorders in Children
10. WorldHeart Announces Further Milestone in Miniaturized Assist Pump Development
11. S*BIO to Develop New JAK-2 Inhibitor for Treatment of Myeloproliferative Disorders and Hematological Malignancies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... 11, 2014 The consumer marketing playbook ... industry sectors to better identify winning tools and ... engage with and understand consumers, as new technologies ... critical purchasing decisions. According to ... one area where organizations can observe a deep ...
(Date:7/11/2014)... -- Research and Markets has announced the ... Film Industry Report 2014" report to their offering. ... Global And Chinese Medical X-Ray Film Industry Report 2014 ... state of the Global medical X-ray film industry with ... provides a basic overview of the industry including definitions, ...
(Date:7/11/2014)... , July 11, 2014 Research and ... Hypodermic Needles Market 2014-2018" report to their offering. ... A hypodermic needle is a hollow needle commonly used ... or or to extract fluids from it. A hypodermic ... to inject substances that cannot be ingested. Hypodermic needles ...
Breaking Medicine Technology:New Technologies Transforming Consumer Marketing Research Playbook 2Global and Chinese Medical X-ray Film Industry Report 2014 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 2Global Hypodermic Needles Market 2014-2018: Key Vendors are Becton, Dickinson and Co, Covidien, Retractable Technologies and Terumo Corp. 3
... River Systems, Inc. announces today that it has ... Massachusetts Institute of Technology (M.I.T.) to utilize advanced ... and Fusion Center in collaboration with Still River. ... with its own leading-edge developments in its groundbreaking ...
... 22, 2011 CardioFocus, Inc., developer of the HeartLight™ ... fibrillation (AF), announced today that its technology will be ... European Heart Rhythm Association (EHRA) EUROPACE 2011 congress, June ... is a unique catheter ablation technology that incorporates an ...
Cached Medicine Technology:Still River Systems Sign Patent License Agreement With the Massachusetts Institute of Technology 2CardioFocus HeartLight™ Endoscopic Ablation System to be Featured at EHRA EUROPACE 2011 2CardioFocus HeartLight™ Endoscopic Ablation System to be Featured at EHRA EUROPACE 2011 3
(Date:7/14/2014)... new analysis has found that rates of testicular cancer ... Hispanic American men, but not among their non-Hispanic counterparts. ... journal of the American Cancer Society, the findings indicate ... of testicular cancer in Hispanic adolescents and young adults, ... cause of this trend. , Testicular cancer is one ...
(Date:7/14/2014)... EurekaMag.com has newly published results of 64,900 ... disease that ranges in severity from a mild ... illness that attacks the liver. An estimated 3.2 million ... virus infection of which approximately 80% of people develop ... all studies on Hepatitis C , the Life, Earth ...
(Date:7/14/2014)... Wa (PRWEB) July 14, 2014 ... Violet Protocol book review recently updated by ... consists of a wide range of simple ... of endometriosis including:, ... meat and dairy products ,     Increasing ...
(Date:7/14/2014)... 2014 Carepoint has been designed ... by combining an intuitive interface for recording, sending, ... service tracking and reporting features. , Hall mc ... teamed up with Rebecca de Witte to create ... organizations. , Carepoint provides seamless, real-time ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 Vaginal ... continues against seven different pelvic mesh manufacturers in the ... Wright & Schulte LLC. The federal complaints are pending ... No. 2327), American Medical Systems (MDL No. 2325), and ... 16th, there are 58,262 Vaginal Mesh lawsuit claims pending, ...
Breaking Medicine News(10 mins):Health News:Testicular cancer rates are on the rise in young Hispanic Americans 2Health News:EurekaMag.com Publishes 64,900 New Studies on Hepatitis C 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 2Health News:Endometriosis Bible and Violet Protocol Book Review Exposes Zoe Brown's Endometriosis Treatment Guide – Vkool.com 3Health News:Home Health Care Professional and Marketing Firm Team Up to Create New Homecare Communication App 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 2Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 3Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 4Health News:Nearly 60,000 Vaginal Mesh Lawsuit Claims Filed Against Seven Different Pelvic Mesh Manufacturers 5
... Committee handed a major victory to the health care industry ... a "public option" to compete against private health insurance providers ... system. The industry has fought the public option with lobbying ... fearing that the proposed policy would cut into their record ...
... ROCKVILLE, Md., Sept. 30 The U.S. Food and ... Consumer Update videos. , (Logo: http://www.newscom.com/cgi-bin/prnh/20090824/FDALOGO ... , http://www.fda.gov/ForConsumers/ConsumerUpdates/ucm182842.htm , ... Approximately 30,000 Americans go to the emergency room each ...
... Corporation ("Select") (NYSE: SEM ), the parent of Select ... public offering of common stock at a price of $10.00 ... Select,s stock began trading on the New York Stock ... Total net proceeds to Select from the offering, after deducting ...
... Simmons firm, a leading national law firm in the fight ... Miles for Meso 5K run/walk on Sunday, October 11, in ... www.milesformeso.org . , The Simmons firm ... in Alton, Ill. Nearly 500 runners and walkers registered, and ...
... ... ), a comprehensive New Jersey anti-poverty charity, is serving more than 500 hot meals ... Services Corp. ( http://www.servicer.com ) and Rapid Pump & Meter Service Co., Inc., ( ... , ...
... problems later , WEDNESDAY, Sept. 30 (HealthDay News) -- New ... reduces the risk for neurological problems later. , Unfortunately, the ... disability. , Still, the findings, appearing in the Oct. 1 ... help fill a crucial gap in the effort to treat ...
Cached Medicine News:Health News:Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out 2Health News:Insurance Industry Successful in Initial Fight Against Public Option; Public Feels Left Out 3Health News:FDA Consumer Health Information Updates: New Web Videos Educate Consumers About Food and Medical Product Safety 2Health News:Select Medical Holdings Corporation Successfully Completes Initial Public Offering of Common Stock 2Health News:Simmons Law Firm Presents Second 'Miles for Meso' Walk/Run Fundraiser for Mesothelioma Research 2Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 2Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 3Health News:A New Jersey Anti-Poverty Charity Meets a Crisis of Need with Charitable Giving from Local Paterson, NJ Small Businesses 4Health News:Cooling Helps Oxygen-Deprived Newborns 2Health News:Cooling Helps Oxygen-Deprived Newborns 3
Solid steel construction for lifelong quality. Strong, smooth and quiet electro-mechanical up/down movement. Dual castor, locking wheels for use on carpet or tile flooring. Easy cleaning, deluxe lami...
Trial lens set +/- Cyl....
... control panel with 3 charging wells. Available ... Colonial Blue and Cinnamon. Spring balanced refractor ... and steel construction for lifelong quality. Sealed ... up/down chair movement. Chair back reclines manually ...
Our Ophthalmic Diagnostic Sets offer everything an eye care specialist needs. Complete your set with your choice of ophthalmoscope, retinoscope, handle, and case....
Medicine Products: