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Two-Year Follow-Up Data Demonstrates Preservation of Adequate Mitral Valve Area in Patients Treated with the MitraClip(R) System
Date:12/4/2008

MENLO PARK, Calif., Dec. 4 /PRNewswire/ -- Long-term data published in EuroIntervention showed that the expected decrease in Mitral Vale Area (MVA) after repair with the MitraClip(R) system to correct mitral regurgitation (MR) is not associated with clinically significant mitral stenosis. Additionally, with two years of follow-up, none of the patients treated with the MitraClip(R) system required surgery for mitral stenosis. At 12 months no important differences were reported between the use of one or two MitraClip(R) devices or based on the etiology of MR.

The analysis was conducted to assess diastolic mitral valve function after percutaneous repair. Echocardiographic measurements of MVA and mean trans- Mitral Valve Gradient (MVG) were made in 96 patients implanted with the MitraClip(R) device. Patients were followed for up to two years.

The MitraClip(R) system is the first commercially available medical device which provides a non-surgical mitral valve repair option for patients suffering from the effects of MR. The MitraClip(R) system is available commercially in Europe and is currently in late stage clinical trials in the United States.

MR affects millions of people worldwide and is the most common type of heart valve insufficiency in Europe and in the United States. The vast majority of patients with significant MR are untreated, which leaves their hearts affected by the chronic volume overload caused by MR, requiring the heart to work harder, and ultimately leading to heart failure.

"It is important to know that the encouraging results from use of the MitraClip(R) system were maintained at two years without mitral stenosis," said Howard C. Herrmann, M.D., director, Interventional Cardiology and Cardiac Catheterization Laboratories at the hospital of the University of Pennsylvania and lead author of the manuscript. "With these results, we have a growing body of evidenc
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SOURCE Evalve, Inc.
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