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Two Studies Test Impact of Drugs to Slow Progression of Type 1 Diabetes
Date:6/27/2011

es occur and continues long after it is diagnosed, often until no insulin production remains. During the early months after diabetes is diagnosed, most people still have some functioning beta cells. These cells, with the help of insulin injections, make it easier to control blood glucose. If this period can be extended, researchers hope that more people will be able to achieve better control of their blood glucose.  In some cases, intervention may be possible before clinical diabetes develops.

TrialNet researchers are conducting a series of studies to test ways to prevent or delay progression of type 1 diabetes. At this week's ADA meeting, TrialNet researchers will announce two ongoing studies aimed at preventing or delaying type 1 diabetes in people at high risk for the disease: relatives of people who already have it. One trial is testing an experimental drug called teplizumab, another immune system modulator; the other study is testing oral insulin, which may induce tolerance, or a quieting of the immune responses that lead to type 1 diabetes.  Several other TrialNet reports will be presented that expand our understanding of how type 1 diabetes develops.

Type 1 diabetes appears to involve both genetic risk factors and less understood environmental factors that may interact to initiate the development of diabetes. To identify people at high risk for type 1 diabetes, TrialNet offers free screening for relatives of people with the disease. Screening involves a simple blood test for markers (autoantibodies) that often appear years before diabetes develops. Knowing the number and type of markers makes it possible to identify those at different risk levels for developing type 1 diabetes. Among people with a relative with type 1 diabetes, the chances of developing the disease are 15 times greater than for those with no family history. Screening can refine this risk estimate.

Nearly 200 U.S. TrialNet locations offer screening and conduct s
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SOURCE TrialNet
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