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Two Studies Test Impact of Drugs to Slow Progression of Type 1 Diabetes
Date:6/27/2011

5 people, ages 3 to 45, with newly diagnosed type 1 diabetes. Participants were randomized into three groups to receive two or three doses of GAD-alum or alum alone over 4 to 12 weeks. During one year of treatment, the vaccine showed no evidence of preserving insulin secretion.

Adverse effects were minimal for both drugs, especially among children, who account for the majority of people with type 1 diabetes.  

"We learn something important from every study, and we build on everything we learn.  Both positive and negative studies help us develop more effective strategies to prevent and treat type 1 diabetes," said TrialNet Study Group Chair Jay Skyler, M.D. "We will continue to follow people in both studies.  It is still early, but there is good reason to believe that some of the drugs being developed to alter immune responses, either alone or in combination with other therapies, will lead to treatments that prevent, postpone, or stop progression of type 1 diabetes."

Type 1 diabetes is an autoimmune disease that accounts for 5 to 10 percent of diagnosed cases of diabetes in the United States—up to 2.5 million people. It develops when a person's own immune system destroys beta cells in the pancreas. Beta cells sense blood glucose and produce the hormone insulin, which regulates glucose levels and converts it to energy. Formerly called juvenile onset diabetes, type 1 diabetes usually develops in children and young adults. To maintain good control of their blood glucose levels, people with this form of diabetes typically need three or more insulin injections a day or treatment with an insulin pump, as well as careful monitoring of blood glucose and attention to diet and exercise.  Well controlled glucose is critical to preventing or delaying serious damage to the eyes, nerves, kidneys, heart, and blood vessels.

The destruction of insulin producing cells by the immune system begins well before the symptoms of diabet
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SOURCE TrialNet
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