Navigation Links
Two Studies Test Impact of Drugs to Slow Progression of Type 1 Diabetes
Date:6/27/2011

ROCKVILLE, Md., June 27, 2011 /PRNewswire-USNewswire/ -- Results of two studies testing drugs to slow or stop the immune system's attack on insulin-producing cells in people newly diagnosed with type 1 diabetes will be presented at the American Diabetes Association's (ADA) 71st Scientific Sessions in San Diego and simultaneously published online in the Lancet. The studies were conducted by the National Institutes of Health's international network of researchers, Type 1 Diabetes TrialNet Study Group, led by the National Institute of Diabetes and Digestive and Kidney Diseases.

Both TrialNet studies aimed to preserve secretion of insulin, the hormone that controls blood glucose levels; one with the drug abatacept, and the other with a vaccine called glutamic acid decarboxylase (GAD).  When type 1 diabetes is diagnosed, most patients retain a limited ability to make insulin, which is generally lost rapidly over the following one to two years. All study participants received intensive management of their diabetes during the trial, with a goal of keeping HbA1c levels within current ADA recommendations.

In the first study, abatacept (Orencia), an immune system modulator currently used to treat several inflammatory diseases, was evaluated in 112 people, ages 6 to 36, with newly diagnosed  type 1 diabetes. Participants were randomized to receive injections of either abatacept or placebo over two years. The group treated with abatacept had a 9.6 month delay in the progression of loss of insulin production.  After two years, a marker for the production of insulin was 59 percent higher in the participants treated with abatacept compared to the placebo group. Long-term retention of the ability to make even small amounts of insulin is associated with better glucose control and improved outcomes in diabetes.  

In the second study, GAD-alum, an antigen based therapy aiming to suppress the immune response, was tested in 14
'/>"/>

SOURCE TrialNet
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Studies Show Effect of BYDUREON™ on A1C and Weight for Up to Three Years
2. Pearl Therapeutics Advances Its Long-Acting Bronchodilator Combination Product Candidate into Four Additional Phase 2 Studies
3. Best of ASCO Features Two Studies Led by US Oncology Research Affiliated Physicians
4. Data from Clinical Studies of bioTheranostics CancerTYPE ID® and Breast Cancer Index(SM) Molecular Diagnostic Tests Presented at ASCO 2011 Annual Meeting
5. Pharmacyclics Reports Recent Developments From Clinical Studies of its Btk Inhibitor PCI-32765
6. Genomic Health Presents Ten New Studies in Breast, Colon and Prostate Cancers at the American Society of Clinical Oncology (ASCO) Annual Meeting
7. Additional Data From Multiple Phase 1 and 2 Studies of S*BIOs Novel JAK2 Inhibitor SB1518 Demonstrate Safety and Efficacy for Treatment of Symptomatic Myelofibrosis (MF)
8. Novartis highlights extensive data on numerous compounds at ASCO in multiple cancers, including Phase III studies in GIST and myelofibrosis
9. Genomic Health Announces Ten Studies Covering Breast, Colon and Prostate Cancers Accepted for Presentation at the American Society of Clinical Oncology (ASCO) Annual Meeting
10. Lilly Oncology to Unveil Data From More Than 30 Studies at ASCO
11. New Studies Support CardioFocus HeartLight™ Endoscopic Ablation Systems Notable Treatment Results for Paroxysmal Atrial Fibrillation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... -- Johnson & Johnson (NYSE: JNJ ) will webcast its ... Thursday, April 23, 2015, from the State Theatre in ... other interested parties may access the live audio webcast of ... and clicking on the webcast icon. A ... a few hours after the live meeting concludes.  The webcast ...
(Date:3/27/2015)... , March 27, 2015  Delcath Systems, Inc. ... medical device company focused on oncology with an ... liver cancers, announces the reporting of data from ... Hydrochloride for Injection with the Delcath Hepatic Delivery ... presentation at the Society of Surgical Oncology (SSO) ...
(Date:3/27/2015)... NEW YORK , March 27, 2015 ... ), the leading source of health information, ... on the new National Action Plan ... interview, President Obama emphasized the urgency and ... impact on national and global health.    ...
Breaking Medicine Technology:Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 2Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 3Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 4Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 5Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 2Exclusive: WebMD Interviews President Obama About Plan for Combating Antibiotic Resistance 3
... new study,demonstrated that the active ingredient in Amitiza ... symptom relief rates in adults,with irritable bowel syndrome ... late-breaker at Digestive Disease Week,2007, the largest annual ... study, patients receiving lubiprostone were nearly,twice as likely ...
... HCT 40/12.5 and 40/25 mg/day and Amlodipine ... American Society of,Hypertension Twenty-Second Annual Scientific Meeting, ... New data,presented today at the American Society ... in Chicago,demonstrated that the fixed-dose combination Benicar ...
Cached Medicine Technology:New Study Demonstrates that Lubiprostone May Improve Symptom Relief,Rates in Adults with Irritable Bowel Syndrome with Constipation,(IBS-C) 2New Study Demonstrates that Lubiprostone May Improve Symptom Relief,Rates in Adults with Irritable Bowel Syndrome with Constipation,(IBS-C) 3New Study Demonstrates that Lubiprostone May Improve Symptom Relief,Rates in Adults with Irritable Bowel Syndrome with Constipation,(IBS-C) 4New Study Demonstrates that Lubiprostone May Improve Symptom Relief,Rates in Adults with Irritable Bowel Syndrome with Constipation,(IBS-C) 5New Study Demonstrates that Lubiprostone May Improve Symptom Relief,Rates in Adults with Irritable Bowel Syndrome with Constipation,(IBS-C) 6Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 2Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 3Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 4Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 5Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 6Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 7Benicar HCT Reductions in Seated Systolic Blood Pressure for Stage,2 Patients Compared With Amlodipine + Benazepril 8
(Date:3/29/2015)... Chicago, IL (PRWEB) March 29, 2015 ... Foundation for Women’s Cancer announce today that ... 2015 recipient of the Claudia Cohen Research Foundation Prize ... presented at the Society of Gynecologic Oncology 46th Annual ... is Director of the Cedars-Sinai Women’s Cancer Program at ...
(Date:3/29/2015)... At this initial launch, the ... health information around medical conditions that individuals face, ... as well as helping them find solutions to ... conditions using evidenced based information in print and ... around them., ,     Diabetes, , ...
(Date:3/29/2015)... (PRWEB) March 29, 2015 North American ... PT Online Continuing Education Courses . ... hours of CME - TPTA, approval # 56399TX      ... evaluation of the shoulder complex - 10.5 hours - ... #56400TX , Examination and Treatment of the SI Joint ...
(Date:3/28/2015)... AZ (PRWEB) March 28, 2015 Coffee could ... also help protect you from gum disease, researchers have found. ... against gum disease. , Coffee contains antioxidants. Antioxidants fight gum ... the question researchers at Boston Univ. Henry M. Goldman School ... in the August 2014 issue of the Journal of Periodontology. ...
(Date:3/28/2015)... Take a bite of warm, gooey pepperoni pizza, ... into the stomach, ready to break down your meal. ... acids run amok, triggering a burning sensation in the ... 60 million Americans have heartburn at least once a ... how it can be stopped. , Heartburn or acid ...
Breaking Medicine News(10 mins):Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 2Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 3Health News:Dr. Beth Y. Karlan Named Recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher 2015 4Health News:Krame Health Solutions Announces Release of AfroHealthLink, an Interactive Health Resource Center Tailored to Individuals of African & Caribbean Descent Around the World 2Health News:Krame Health Solutions Announces Release of AfroHealthLink, an Interactive Health Resource Center Tailored to Individuals of African & Caribbean Descent Around the World 3Health News:New Research Impliments Coffee May Help Fight Gum Disease and Increasing Benefits With Tylers Coffee 2Health News:Bypass Your Heartburn Worries This Easter With Tylers Coffee 2
... fibroids, who until now had only an option of a ... of shrinking the fibroid with the drug Mifepristone. Lead researcher ... and vexing problem in women and fibroid relief accounts for ... are symptomatic could have back pain, pain with intercourse, problems ...
... for a long time to its ultraviolet rays, has always been ... German scientists has shown that even moderate sun exposure can result ... skin cancer. Exposure to sun has been shown as the main ... and melanoma, the rarest type of skin cancer, is much weaker. ...
... genetic mutation called C150T transition in people over 100 years ... This genetic mutation was found in the mitochondrial DNA of ... 52 Italian centenarians. The researchers found that 17 per cent ... in only 3.4 per cent of 117 control subjects under ...
... method by which arterial stiffness in elderly hypertensive patients ... is measured by computerized oscillometry at the upper arm. ... Japan studied 42 patients, 26 of whom were over ... and compared it with other methods of evaluating arterial ...
... research project carried out by Juliette van den Dolder at ... can be grown into bone fractures with the help of ... a titanium mesh scaffold into a bone fracture in a ... This resulted in new bone growth being stimulated by the ...
... of same-sex twins in which only one twin had smoked ... theory" that pot can lead to harder drugs. The study ... genetic makeup and all the participants were 30 years of ... teenage drug use. The researchers found that those who were ...
Cached Medicine News:Health News:Treatment for fibroids with "Abortion Pill" 2Health News:Bones repair themselves with bone marrow cells 2
... Terason's background in high performance ... in the field of echocardiography. ... resolution, high frame rates, and sensitive ... Ultrasound System, based upon Terason's proprietary ...
The Polygraf ID multi-parametric recorder works with POLYGRAM NET analysis software to create a unique interface that combines web-style navigation, graphical presentation and intuitive design to del...
... Endoscopic cases, it is extremely popular to combine ... Light. This combination affords the surgeon optimal ... an uncomfortable pose. The Single Light System ... System. As such the light can be ...
... DVO-1000MD is the only medical grade DVD recorder ... recorder has two exclusive features DVORECOVERY™ and DVOFAST™, ... friendly recorders ever designed. DVORECOVERY enables the end ... accidental power outage. DVOFAST enables you to remove ...
Medicine Products: