Navigation Links
Two Novel Lilly Molecules Target Genetic Mutations That Can Lead to Cancer
Date:4/4/2011

heres – ultimately metastasizing, or spreading.

Lilly scientists focused on a growth factor called IL-6, which latches onto receptors on the surface of cells and triggers the IL-6–JAK–STAT3 signaling pathway, promoting formation of the deadly IBC cell clusters by activating the STAT3 protein, which then turns on the genes that encourage IBC cells to stick together.  

Researchers hypothesized that short-circuiting the IL-6–JAK–STAT3 pathway could prevent the formation of tumor cell clusters.  The scientists first cultured the tumor spheres in medium containing IL-6.  As expected, IL-6 activated STAT3, the cells proliferated, and the tumor spheres grew.  Furthermore, expression of IL-6 by the spheres themselves increased by 50-fold; and secretion of intracellularly produced IL-6 activated STAT3, and prevented cell death in the tumor spheres.

But when Lilly's JAK2 inhibitor was added to the medium containing the tumor spheres, the scientists found that it inhibited STAT3 activation in a dose-dependent manner and that blocking this signaling pathway induced cell death in the tumor spheres.  The IL-6–JAK–STAT3 pathway may serve as a "molecular signature" of IBC and as a potential therapeutic target.

Lilly's JAK2 inhibitor is currently being evaluated in Phase I clinical trials for the treatment of myeloproliferative neoplasms, or diseases of the blood and bone marrow, called polycythemia vera, essential thrombocythemia and myelofibrosis.  

LY2940680: Halting Abnormal Signaling via the Hedgehog Pathway (Abstract # 2819)

Lilly scientists have identified an orally administered anti-cancer agent, LY2940680, which, in preclinical studies, disrupted the abnormal signaling of a key regulator of embryonic cell development. Data was also presented at AACR's New Small Molecule Therapeutics mini-symposium.  

This novel molecule has been shown
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Jan. 23, 2015 For the pharmaceutical industry, marketplace success ... payers. Likewise, the importance of the managed markets function - ... to grow as payer formularies and provider networks play an ... At the same time, managed markets leaders must continually identify ...
(Date:1/23/2015)... ANGELES , Jan. 23, 2015 A lot of ... best methods for treating  certain illnesses, injuries, or conditions. As ... replace previous treatment methods with ones that they consider to ... hernias, there is not one textbook method of treatment that ...
(Date:1/23/2015)... , Jan. 23, 2015  A new analysis of ... D 2015 enrollment data shows that 81 percent of ... access and extra discounts at certain pharmacies. The findings ... "Preferred pharmacy plans are now the foundation of Medicare ...
Breaking Medicine Technology:As Payer Influence Rises, Pharmaceutical Companies work to Optimize the Managed Markets Function 2No One-Size-Fits-All Remedy for Hernia Correction 2New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2
... YORK, Nov. 5 - Top experts from the,Alzheimer,s ... widespread,utilization of memory screenings, especially in light of ... are not recognized,often enough and that early diagnosis ... Eric J. Hall, AFA,s chief executive officer, ...
... Nov. 5 Synvista Therapeutics,Inc. (Amex: SYI ... as the ICARE,study, being presented today at the ... Florida. The study demonstrated that,supplementing Vitamin E therapy ... Haptoglobin 2-2 (Hp2-2) phenotype met its pre-specified, primary,endpoint ...
Cached Medicine Technology:Experts Call for Widespread Use of Memory Screenings and Emphasize Value of Early Detection of Dementia 2Experts Call for Widespread Use of Memory Screenings and Emphasize Value of Early Detection of Dementia 3Experts Call for Widespread Use of Memory Screenings and Emphasize Value of Early Detection of Dementia 4Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing 2Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing 3Synvista Therapeutics Highlights New Data Demonstrating the Clinical Benefit of Vitamin E Therapy in Patients Identified on the Basis of Haptoglobin Phenotype Testing 4
(Date:1/22/2015)... (PRWEB) January 22, 2015 For over 20 years, ... Oceanside and Vista area has treated just about every ... personal injury circumstances. And for those same twenty-plus years, the ... of all those injuries with the best possible doctor. ...
(Date:1/22/2015)... 22, 2015 Yesterday, Senator Holly ... and Kristin Olsen (R-Modesto) were honored by the ... advancing biotechnology, biomedical science, medical device and pharmaceutical ... received the “2014 Life Sciences Champion” award from ...
(Date:1/22/2015)... Payday lending practices in four southern ... financial distress to the states that permit them, according ... Center on Race and Wealth. , While they generate ... loans at the same time substantially depress economic activity, ...
(Date:1/22/2015)... Compare-autoinsurance.org has released a new blog post presenting a ... insurance policy . , Some types of vehicles cannot be ... newly released blog post to see if their vehicle qualifies for ... are some of the cars that cannot be covered by a ...
(Date:12/26/2014)... 2014 The US represents the largest market ... 2013, GlobalData’s forecast estimates that sales of branded therapies were ... to the high incidence of the disease, high drug treatment ... and China. Increased sales of CRC therapies over the forecast ...
Breaking Medicine News(10 mins):Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 2Health News:California Biomedical Community Honors Senator Holly Mitchell, Assemblymembers Susan Bonilla & Kristin Olsen 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Some Vehicles Cannot Be Covered By An Auto Insurance Policy! 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 2Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 3Health News:US Colorectal Cancer Drug Market Analysis and Forecast to 2023 Report Available at ReportsnReports.com 4
... , BEDFORD, Mass., July 13 Hologic, Inc. (Hologic ... leading developer, manufacturer and supplier of premium diagnostics, medical ... healthcare needs of women, today announced plans to release ... August 3, 2009 after market close. In conjunction with ...
... July 13 Long term care costs in Wyoming continue ... pressure on those in or near retirement. As a leader ... suite of insurance products to help people proactively plan for ... take advantage of a new program designed to simplify the ...
... WALTHAM, Mass., July 13 Decision Resources, one of the ... healthcare issues, finds that the rheumatoid arthritis (RA) drug market ... in 2008 to $385 million in 2013. This growth will ... to healthcare insurance, greater patient spending power and increased use ...
... , , , ... July 13 CareGuide, Inc., an emerging health management company, welcomes ... as Area Vice President of Sales. Both are located in Texas ... location. , , Julie Sizemore ( ...
... RATON, Fla., July 13 Laura E. Skellchock, M.D. at Integrative ... collagen filler for the correction of smile lines, to treat patients ... has been an avid Artefill user the past several years due ... , , "It,s the perfect ...
... Calif., July 13 Sit ,n Sleep, the mattress ... millions of Southern Californians, today launched a new campaign ... right mattress and improved sleep health and well-being. Widely-known ... in town, Sit ,n Sleep,s new strategic direction ...
Cached Medicine News:Health News:Hologic to Release Third Quarter Fiscal 2009 Operating Results on Monday, August 3, 2009 2Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Wyoming AARP Members 2Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Wyoming AARP Members 3Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Wyoming AARP Members 4Health News:Genworth Financial Simplifies the Process of Purchasing Affordable Long Term Care Insurance for Wyoming AARP Members 5Health News:China's Rheumatoid Arthritis Drug Market Will More than Double by 2013 2Health News:China's Rheumatoid Arthritis Drug Market Will More than Double by 2013 3Health News:CareGuide Adds New Management Team Members 2Health News:Integrative Dermatology of Boca Raton Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 2Health News:Integrative Dermatology of Boca Raton Selects Artefill to Meet Growing Patient Demand for a Longer Lasting Dermal Filler 3Health News:Sit 'n Sleep Refocuses on Consumer Sleep Health and Well-Being 2Health News:Sit 'n Sleep Refocuses on Consumer Sleep Health and Well-Being 3Health News:Sit 'n Sleep Refocuses on Consumer Sleep Health and Well-Being 4
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: