Navigation Links
Two Novel Lilly Molecules Target Genetic Mutations That Can Lead to Cancer
Date:4/4/2011

heres – ultimately metastasizing, or spreading.

Lilly scientists focused on a growth factor called IL-6, which latches onto receptors on the surface of cells and triggers the IL-6–JAK–STAT3 signaling pathway, promoting formation of the deadly IBC cell clusters by activating the STAT3 protein, which then turns on the genes that encourage IBC cells to stick together.  

Researchers hypothesized that short-circuiting the IL-6–JAK–STAT3 pathway could prevent the formation of tumor cell clusters.  The scientists first cultured the tumor spheres in medium containing IL-6.  As expected, IL-6 activated STAT3, the cells proliferated, and the tumor spheres grew.  Furthermore, expression of IL-6 by the spheres themselves increased by 50-fold; and secretion of intracellularly produced IL-6 activated STAT3, and prevented cell death in the tumor spheres.

But when Lilly's JAK2 inhibitor was added to the medium containing the tumor spheres, the scientists found that it inhibited STAT3 activation in a dose-dependent manner and that blocking this signaling pathway induced cell death in the tumor spheres.  The IL-6–JAK–STAT3 pathway may serve as a "molecular signature" of IBC and as a potential therapeutic target.

Lilly's JAK2 inhibitor is currently being evaluated in Phase I clinical trials for the treatment of myeloproliferative neoplasms, or diseases of the blood and bone marrow, called polycythemia vera, essential thrombocythemia and myelofibrosis.  

LY2940680: Halting Abnormal Signaling via the Hedgehog Pathway (Abstract # 2819)

Lilly scientists have identified an orally administered anti-cancer agent, LY2940680, which, in preclinical studies, disrupted the abnormal signaling of a key regulator of embryonic cell development. Data was also presented at AACR's New Small Molecule Therapeutics mini-symposium.  

This novel molecule has been shown
'/>"/>

SOURCE Eli Lilly and Company
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Novel Technology Breaks Through Cancer Pain
2. Iomai Trial Shows 100 Percent Immune Response in Elderly Subjects Vaccinated With Novel Travelers Diarrhea Patch Vaccine
3. Pharmacopeia Assists the World Health Organization in the Discovery of Novel Therapeutics for the Treatment of Malaria
4. Quark Pharmaceuticals Files Patent Application Covering Novel Chemical Modifications to its RNAi Molecules
5. Ardea Biosciences, Inc. Announces Completion of Phase 1 Clinical Trials of Novel Investigational HIV Drug RDEA806
6. The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor
7. Study Results for Aclidinium Bromide, a Novel Anticholinergic, Presented at European Respiratory Society Annual Congress
8. Phase 2 Clinical Studies Initiated for a Novel Therapeutic Candidate Identified Through Pharmacopeia Collaboration
9. Oncology Drugs Development Update - Worldwide Markets and Forecasts of Approved EGFr/HEr2 Inhibitors, Treatment Costs, Pathway Analysis, Current and Expanded Clinical Indications, and Novel Agents in Development
10. ECLIPSE Data on Effects of Otsukas Investigational Novel Treatment, Tolvaptan, on Advanced Heart Failure Patients Hemodynamics and Urine Output Featured in Heart Failure Society of Americas Late Breaking Trials
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... , Aug. 21, 2014 /CNW/ - Eisai Limited is ... introduction of the first-of-its-kind comic book available in ... has been designed specifically to educate children and their parents ... Canada affecting more than 300,000 Canadians. Eisai is ... care (hhc) , in which the patient is central – ...
(Date:8/21/2014)... Germany , Aug. 21, 2014  IBM (NYSE: ... Elektronen-Synchrotron ( DESY ), a leading national research center ... management and storage of massive volumes of x-ray data. ... based on IBM software defined technology can handle more ... performance and help scientists worldwide gain faster insights into ...
(Date:8/21/2014)... August 21, 2014 BreedIT ... Ltd., the exclusive worldwide license holder and distributor ... breeders and researchers, today is pleased to announce ... with Seach Ltd, a leading Israeli medical Cannabis ... and develop new breeds of medical Cannabis to ...
Breaking Medicine Technology:Eisai Pleased to Support Canadian Epilepsy Alliance Comic Book that Teaches Children About Epilepsy 2DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4
... Sept. 2, 2011 SimonMed and Cox Business have ... called tomosynthesis available to patients in the Valley and ... traditional digital mammogram. This is the first dedicated outpatient ... offered at SimonMed,s office in Scottsdale. Sub-specialty ...
... Pharmaceuticals International, Inc. (NYSE: VRX ) (TSX: VRX) ... will be participating at the following conferences: ... a presentation at the Bank of America Merrill Lynch Global ... at 10:35 a.m. BT (5:35 a.m. ET). ...
Cached Medicine Technology:SimonMed and Cox Business Bring Breast Tomosynthesis to Arizona 2
(Date:8/21/2014)... 21, 2014Popular fiction that normalizes and glamorizes violence against ... be associated with a greater risk of potentially harmful ... new study are presented in the article " Fiction ... in Adolescent and Young Adult Females ," published in ... from Mary Ann Liebert, Inc., publishers . The ...
(Date:8/21/2014)... Individuals with schizophrenia often have trouble engaging in daily ... study from San Francisco State University suggests the reason ... effort required to complete tasks. , The research, detailed ... Journal of Abnormal Psychology , can assist health professionals ... help those patients function normally by breaking up larger, ...
(Date:8/21/2014)... August 21, 2014 Entries are now ... the only comprehensive national awards program totally dedicated to ... development and executive leadership. The entry deadline is Oct. ... Real Estate Insights™, the first and only national magazine ... and investment. , “We launched the HREI Insights Awards ...
(Date:8/21/2014)... York, New York (PRWEB) August 21, 2014 ... Medical Cannabis Network that a company located in Massachusetts ... be the only marijuana patient verification system ... to welcome this new entity to our growing and ... to our belief that these claims are inaccurate. ...
(Date:8/21/2014)... Steven Reinberg HealthDay Reporter ... shows promise in treating respiratory syncytial virus (RSV), a leading ... finally making major progress in being able to treat human ... viral pneumonia, second only to influenza virus," said study author ... of Tennessee College of Medicine in Memphis. "There ...
Breaking Medicine News(10 mins):Health News:Women's health and Fifty Shades: Increased risks for young adult readers? 2Health News:Difficulty assessing effort drives motivation deficits in schizophrenia, study finds 2Health News:Entries Open for 2014 HREI Insights Awards™ 2Health News:Entries Open for 2014 HREI Insights Awards™ 3Health News:Entries Open for 2014 HREI Insights Awards™ 4Health News:MarijuanaDoctors.com Responds to Massachusetts Company's Claim 2Health News:New Drug May Fight Serious Respiratory Virus in Infants 2Health News:New Drug May Fight Serious Respiratory Virus in Infants 3
... Denmark, Thursday 11 June 2009: Nulliparous women (those who ... chronic arthritides (including ankylosing spondylitis, psoriatic arthritis and rheumatoid ... women (those who have given birth to children), according ... the Annual Congress of the European League Against Rheumatism ...
... As Congress prepares to debate a major overhaul of the ... support of several proposals to expand coverage that have been ... Health Confidence Survey released today. But attitudes could change as ... , Between 68 percent and 88 percent of Americans either ...
... SYK ) announced today that it will host a conference ... to discuss the Company,s operating results for the quarter ended June ... quarter ended June 30, 2009 will be released at 4:00 p.m. ... dial 866-700-0133 (domestic) or 617-213-8831 (international) and ...
... in whether women decide to go for cancer screening or not, ... wrongly assume that they will ask for information if they want ... study published in the June issue of the UK-based Journal ... and Dr Stephanie Preston reviewed 19 studies that between them explored ...
... Quality of Life of Injured Veterans , , ... by Kessler Foundation Research Center published in Brain ... Injury Association, uncovered the possible cause of cognitive fatigue ... fatigue has been shown to be one of the ...
... at August Luncheon , , DENVER, June 11 ... of kidney care services for those diagnosed with chronic kidney ... the Los Angeles Business Journal ,s 2009 "Best Places ... 67 companies chosen for their impact on the region,s economy, ...
Cached Medicine News:Health News:Diagnosis of arthritis 5 years earlier in childless women compared to those with children 2Health News:12th Annual Health Confidence Survey: Americans Show Support for Several Health Coverage Options, But Their Views Could Change as More Details Emerge 2Health News:12th Annual Health Confidence Survey: Americans Show Support for Several Health Coverage Options, But Their Views Could Change as More Details Emerge 3Health News:Stryker to Host Conference Call on July 21, 2009 2Health News:Cancer screening fear is fueled by lack of information says review covering nearly 6,000 women 2Health News:Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury 2Health News:Kessler Foundation Research Center Study Provides Insight into One of the Most Challenging Symptoms Following a Traumatic Brain Injury 3Health News:DaVita Named to List of 'Best Places to Work in Los Angeles' by the Los Angeles Business Journal 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: