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Two New Studies in the New England Journal of Medicine Show Malaria Vaccine Candidate Advancing in Africa
Date:12/8/2008

starting in the near future," said Philip Bejon of Kenya Medical Research Institute (KEMRI)-Wellcome Collaborative Research Programme and the Centre for Tropical Medicine, University of Oxford, the study's lead author.

The team for the efficacy trial of RTS,S/AS01 in young children comprised researchers from the KEMRI-Wellcome Collaborative Research Programme (Kilifi, Kenya), the National Institute for Medical Research (Tanzania), the Joint Malaria Programme (Korogwe, Tanzania), and other institutions in collaboration with GSK and the MVI.

About RTS,S/AS

GSK and the PATH Malaria Vaccine Initiative signed a public-private partnership agreement in 2001 to pursue pediatric clinical development of RTS,S/AS in Africa. To advance the development program, African research centers in five countries, and collaborating institutions, joined with the partnership.

Pending approvals by national regulatory agencies and ethics committees, a multi-center phase III efficacy trial is on track to start in early 2009. The trial will seek to confirm and evaluate with precision the vaccine's efficacy, including duration, and will continue to closely monitor safety.

The vaccine was invented, developed and manufactured in laboratories at GSK Biologicals' headquarters in Belgium in the late 1980s and initially tested in US volunteers as part of a collaboration with the US Walter Reed Army Institute of Research.

Funding for the development of this vaccine candidate has been made possible through a US$107.6 million grant from the Bill & Melinda Gates Foundation to the PATH Malaria Vaccine Initiative. GSK has invested approximately $300 million to date and expects to invest another $50-100 million before the completion of the project.

The clinical development of RTS,S/AS is led by the Clinical Trial Partnership Committee, a collaboration of leading African resea
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SOURCE PATH Malaria Vaccine Initiative
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