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Two New Studies Report Increased Survival Rates in Tamiflu(R)-Treated Patients with Avian Flu (H5N1) and Severe Seasonal Flu
Date:9/13/2009

SAN FRANCISCO, Sept. 13 /PRNewswire/ -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced today that two new observational studies concluded that influenza patients treated with Tamiflu(R) (oseltamivir phosphate) had significantly higher survival rates than untreated patients. The studies, examining nearly 1,000 people, analyzed outcomes for two different groups -adults and children diagnosed with the highly pathogenic A (H5N1) avian influenza and adults hospitalized with seasonal influenza. Results, which build on similar findings(i), were presented today at the 49th ICAAC annual meeting in San Francisco.(ii,iii)

"These retrospective studies support the potential benefits of antiviral treatment in severe cases of influenza," said Dominick Iacuzio, Ph.D., medical director at Roche, which manufactures Tamiflu. "While Tamiflu is approved and used in many countries to treat and prevent all types of A and B influenza, these 'real-world' studies contribute to the body of clinical evidence."

Study Summaries

First Results from an Avian Influenza Case Registry (Presentation V-533) -- Sunday, September 13, 2009, 9:00 a.m. - 9:30 a.m. PT, Marriott Salon 9.

The study examined outcomes data for 215 patients from 10 countries who were diagnosed with the virulent A (H5N1) avian influenza. The retrospective observational study found that untreated patients had a mortality rate of 88%, with 11 out of 89 (12%) untreated patients surviving, in contrast to survival of 45 out of 85 (53%) patients who received at least one dose of Tamiflu up to 8 days after symptom onset. Among a subset of patients who received Tamiflu within 2 days of symptom onset, 5 out of 7 patients (71%) survived.

The study was conducted by researchers from Avex Avian Influenza Expert Group and the London School of Hygiene and Tropical Medicine, in collaboration with R
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