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Two New Alzheimer's Disease Studies Show Advances Against Different Treatment Targets
Date:7/28/2008

the individual cognitive tests as a function of both treatment and length of treatment.

High dose AL-108 gave a statistically significant improvement in the delayed match-to-sample test (DMTS 12s). After four weeks, a 34.2 percent change from baseline (p=0.067, versus placebo) was seen; by Week 16, a 62.4 percent improvement from baseline was observed (p=0.038, versus placebo), showing a durable response four weeks after treatment ended.

An improvement on the digit span forward test of the high dose group became statistically significant at Week 8, with an 11.2 percent change from baseline (p=0.032, versus placebo), and remained significant at Week 16 with an 11.7 percent change from baseline (p=0.052, versus placebo).

The low dose AL-108 was not different from placebo. AL-108 was well tolerated with similar rates of adverse events (AEs) in placebo and AL-108 treated subjects. The most common AE was headache which occurred at a rate expected in this patient population. No serious AEs were associated with AL-108.

"Twelve weeks of AL-108 treatment given intranasally by spray resulted in a statistically significant, dose-dependent and durable improvement on measures of short-term memory, including visual, verbal, and auditory working memory, which is a type of memory function that deteriorates throughout the progression of Alzheimer's," Schmechel said.

"This makes AL-108 the first drug to validate in humans the importance of the 'tangle' or 'tau' pathway in Alzheimer's. Based on these results in MCI, there are plans for further development of AL-108 in Alzheimer's," Schmechel added.

Insulin and Diabetes Drugs May Reduce Alzheimer's Brain Lesions

Several large-scale studies have shown that people with diabetes have a higher risk of developing Alzheimer's than persons without diabetes. At the same time, previous research showed that some people with diabetes had fewer Alzheimer's-associated brain lesions than non-diabetic
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SOURCE Alzheimer's Association
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