Navigation Links
Two Large, Independent Outcomes Trials Offer New Important Safety Information on Cardiovascular Effects of AVANDIA(R)
Date:6/9/2008

than predicted.

In the trial, investigators said that they were "more aggressive" with AVANDIA and other medications in the intensive arm to achieve and maintain tight glycemic targets. The investigators found that in VADT, there were no increased deaths associated with any of the medications used in the trial, including AVANDIA.

Findings from ACCORD

ACCORD, which investigated whether or not intensive blood control would reduce CV events in patients with type 2 diabetes who had either established cardiovascular disease or additional CV risk factors, was presented at a press conference during the ADA Scientific Sessions and published simultaneously in the New England Journal of Medicine. The study had a mean follow-up of 3.5 years. In total, 7,623 patients enrolled in the ACCORD trial took AVANDIA, representing more than 19,200 patient years of experience with the medication.

The investigators found that, as compared with standard therapy, the use of intensive therapy to reach the study's A1C goal for 3.5 years did not significantly reduce major CV events. Although they found an increase in CV deaths among these high-risk patients who were in the intensive arm, the death rates from ACCORD were substantially lower than investigators predicted at the outset of the trial.

In their analysis, the investigators noted that "preliminary nonprespecified exploratory analyses of episodes of severe hypoglycemia after randomization and differences in the use of drugs (including rosiglitazone), weight change, and other factors did not identify an explanation for the mortality finding."

Additionally, an accompanying editorial in the New England Journal of Medicine states, " ... the ACCORD trial investigators concluded that patients in the standard-control group and those in the intensive-control group had similar risks and rates of death, whether or not they were prescribed rosiglitazone."

Other Studies of AVANDIA

In an integr
'/>"/>

SOURCE GlaxoSmithKline
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Large, Long-Term Veterans Affairs Diabetes Trial (VADT) Reveals Important Cardiovascular Safety News on AVANDIA(R)
2. MultiVu Video Feed: Large, Long-Term Veterans Affairs Diabetes Trial (VADT) Reveals Important Cardiovascular Safety News on AVANDIA
3. Video: New Research Discovers Independent Brain Networks Control Human Walking
4. Facet Solutions AFRS(TM) Demonstrates Biomechanical Advantages Over Dynamic Stabilization in Independent Testing
5. Independent Clinical Results Confirm Up to a 7-Centimeter Reduction in Body Circumference Using UltraShape(TM) Non-Invasive Fat Reduction and Body Contouring System
6. Independent Physician Surveys Show if Approved, MF101 Could Become First-Line Treatment for Menopause Symptoms
7. Independent Data Safety Monitoring Board Recommends Continuation of Sangarts Pivotal Phase III Trials of Hemospan(R) Following Second Interim Review
8. Longevinex(R) Found to be Superior to Green Tea Molecule in Independent Human Study
9. Independent Studies Report on Possible Roles for Cylexs Immune Cell Function Assay in Monitoring of Heart and Lung Transplant Recipients
10. Seven Presentations by Two Independent Research Groups Highlight Advantages of Pressure Cycling Technology (PCT) at Scientific Symposia in Philadelphia, Boston, and New York City
11. Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/29/2015)... Mass. , May 29, 2015  Hologic, Inc. ... has entered into a new, five-year secured credit agreement ... a $1 billion revolving credit facility. Hologic ... and used these proceeds and the Term Loan to ... which had an aggregate principal amount outstanding of $1.69 ...
(Date:5/29/2015)... 29, 2015  Today, UL LLC, a global ... provider of electronic quality management systems (EQMS) and ... will leverage the strengths of both organizations to ... implementation and comprehensive advice and guidance for successful ... capabilities to UL,s strength in regulatory services and ...
(Date:5/29/2015)... Fla. , May 29, 2015  Excite Medical ... in 2007.  Over the years, Excite Medical, under the ... be an enduring company, with a solid track record ... and growing client and distributor base.  ... success of Excite Medical has been possible, in large ...
Breaking Medicine Technology:Hologic Enters into Five-Year Secured Credit Agreement 2Hologic Enters into Five-Year Secured Credit Agreement 3UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 2UL and MasterControl collaborate to provide medical manufacturers full service QMS and Regulatory Submissions support 3
... Conatus Pharmaceuticals Inc. today announced the closing of ... financing.  This financing was led by new investor, AgeChem ... existing investors; Aberdare Ventures, Advent Venture Partners, Bay City ... will use the proceeds to advance the clinical development ...
... Mindray Medical International Limited (NYSE: MR), a leading developer, ... that it will report its financial results for the ... market closes on February 28, 2011. Mindray,s management will ... March 1, 2011 U.S. Eastern Time (9:00 PM on ...
Cached Medicine Technology:Conatus Pharmaceuticals Completes $20 Million Series B Private Placement Financing 2Mindray to Report Fourth Quarter and Full Year 2010 Financial Results on February 28, 2011 2
(Date:5/29/2015)... Ready to hit the road? Before embarking on a big ... vehicles ready. With handicapped vehicles, there are even more things ... ready to help drivers get their handicapped vans ready by ... When planning for the big trip, drivers should be sure ... smoothly and they are prepared for all contingencies: , ...
(Date:5/29/2015)... What does community do? , According ... comes together to plant gardens, to teach young people, ... of critical issues. Community invites everyone to help improve ... "What Community Does" was commissioned by The Denver Foundation, ... released during the foundation’s Annual Celebration in May. At ...
(Date:5/29/2015)... (PRWEB) May 29, 2015 The science ... in Los Angeles thanks to the efforts of internationally ... Mohebi has combined ARTAS hair restoration and ... hair restoration procedures available anywhere. , A Follicular ... and individually harvesting hair follicle grafts from the donor ...
(Date:5/29/2015)... M3 USA MDLinx.com, source of the “ ... now offers The Smartest Rheumatologist . The Smartest ... ranging from Fibromyalgia and Osteoporosis, to Arthritis and Gout. ... and Caroline Tredway, editorial head of The Smartest Doc ... on the physicians who participate. Says Tredway, “With so ...
(Date:5/29/2015)... Rhode Island (PRWEB) May 29, 2015 ... 7, 2015. The event, now closed to new registration, ... Fort Adams. This exciting competitive running event demonstrates ... organizations to create a public benefit – in this ... scenic coastal views around the famed Ocean Drive and ...
Breaking Medicine News(10 mins):Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 2Health News:Advanced Driving Systems Offers Tips for Summer Road Trips 3Health News:What Community Does: A New Video from The Denver Foundation 2Health News:Los Angeles and Beverly Hills Hair Transplant Doctor Now Combines Robotic Hair Restoration (ARTAS) and Manual FUE Transplants for Maximum Hair Coverage 2Health News:MDLinx Launches Smartest Rheumatologist 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 2Health News:The Newport 10 Miler at Fort Adams, an Outstanding Example of Event Marketing Helping in Preservation, is Now Completely Booked for 2015 3
... drug) treatment that can be applied directly to site of ... osteoarthritis pain * Voltaren Gel is the only prescription ... ... the hands * Offers highly effective pain relief with minimal drug absorption, throughout ...
... Adopts InterviewDirect to ... Positions, CHERRY HILL, N.J., Oct. 22 ... telephone-based job candidate screening solutions,today announced that ... InterviewDirect service to pre-qualify job candidates for ...
... and MCLEAN, Va., Oct. 22 Science,Applications International ... it,signed an agreement with the University of Kent ... to collaborate on biometric and,identity projects. Fostered ... (UKTI), the agreement,aims to maximize cooperation from academia, ...
... done in part by researchers at The University of ... discovery of two genes that cause ankylosing spondylitis, an ... published in the Oct. 21 online edition of Nature ... basis for common and complex diseases. , John D. ...
... for elderly patients with lung cancer has changed little ... treatment. The study by Harvard University, National Cancer Institute, ... the December 1, 2007 issue of CANCER, a peer-reviewed ... life-expectancy rose by less than one month between 1983 ...
... can keep vision, other injuries at bay, experts say , , ... can help ensure that Halloween is a treat for both ... America, a nonprofit organization based in Chicago. , "We can ... precautions," Daniel D. Garrett, the group,s senior vice president, said ...
Cached Medicine News:Health News:Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis 2Health News:Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis 3Health News:Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis 4Health News:Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis 5Health News:Voltaren(R) Gel Receives US Regulatory Approval as the First Approved Topical Prescription Treatment for Pain Associated with Osteoarthritis 6Health News:Albert Einstein Healthcare Network Turns to InterviewDirect to Qualify Job Candidates 2Health News:Albert Einstein Healthcare Network Turns to InterviewDirect to Qualify Job Candidates 3Health News:SAIC to Collaborate with UK Biometrics Institute 2Health News:SAIC to Collaborate with UK Biometrics Institute 3Health News:UT rheumatologists discover 2 genes related to disabling form of arthritis 2Health News:UT rheumatologists discover 2 genes related to disabling form of arthritis 3Health News:Spending more for lung cancer treatment did not substantially increase patients' lives 2Health News:Eye on Safety Makes Halloween Less Scary 2
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: