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Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting

discontinuation of therapy

-- DOXIL is an irritant, not a vesicant; use precautions to avoid


-- DOXIL can cause fetal harm when used during pregnancy

-- Recall reaction has occurred with DOXIL administration after


-- DOXIL may interact with drugs known to interact with the conventional

formulation of doxorubicin HCl

-- In patients with multiple myeloma, the most common all-grade ARs

greater than or equal to 20%

(VELCADE plus DOXIL vs VELCADE, respectively) included: neutropenia

(36% vs 22%), thrombocytopenia (33% vs 28%), anemia (25% vs 21%),

fatigue (36% vs 28%), pyrexia (31% vs 22%), asthenia (22% vs 18%),

nausea (48% vs 40%), diarrhea (46% vs 39%), vomiting (32% vs 22%),

constipation (31% vs 31%), mucositis/stomatitis (20% vs 5%), peripheral

neuropathy (42% vs 45%), neuralgia (17% vs 20%), and rash (22% vs 18%)

-- In addition, 19% vs <1% reported HFS Please see full Prescribing Information, including Boxed WARNINGS.

DOXIL is marketed in the United States by Ortho Biotech Products, L.P., and in Israel by Janssen-Cilag. Schering-Plough Corporation, under a licensing agreement, has exclusive rights to market the medication as CAELYX(R) throughout the rest of the world, excluding Japan and Israel. For more information about DOXIL, please visit


VELCADE is being co-developed by Millennium Pharmaceuticals, Inc. and Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Millennium is responsible for commercialization of VELCADE in the U.S.; Janssen-Cilag is responsible for commercialization in Europe and the rest of the world. Janssen Pharmaceutical K.K. is responsible for commercial

SOURCE Ortho Biotech
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