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Twelve DOXIL(R) Clinical Studies to be Presented at American Society of Hematology Annual Meeting
Date:12/7/2007

discontinuation of therapy

-- DOXIL is an irritant, not a vesicant; use precautions to avoid

extravasation

-- DOXIL can cause fetal harm when used during pregnancy

-- Recall reaction has occurred with DOXIL administration after

radiotherapy

-- DOXIL may interact with drugs known to interact with the conventional

formulation of doxorubicin HCl

-- In patients with multiple myeloma, the most common all-grade ARs

greater than or equal to 20%

(VELCADE plus DOXIL vs VELCADE, respectively) included: neutropenia

(36% vs 22%), thrombocytopenia (33% vs 28%), anemia (25% vs 21%),

fatigue (36% vs 28%), pyrexia (31% vs 22%), asthenia (22% vs 18%),

nausea (48% vs 40%), diarrhea (46% vs 39%), vomiting (32% vs 22%),

constipation (31% vs 31%), mucositis/stomatitis (20% vs 5%), peripheral

neuropathy (42% vs 45%), neuralgia (17% vs 20%), and rash (22% vs 18%)

-- In addition, 19% vs <1% reported HFS Please see full Prescribing Information http://www.doxil.com/pdf/DOXIL_PI_Booklet.pdf, including Boxed WARNINGS.

DOXIL is marketed in the United States by Ortho Biotech Products, L.P., and in Israel by Janssen-Cilag. Schering-Plough Corporation, under a licensing agreement, has exclusive rights to market the medication as CAELYX(R) throughout the rest of the world, excluding Japan and Israel. For more information about DOXIL, please visit http://www.DOXIL.com.

About VELCADE

VELCADE is being co-developed by Millennium Pharmaceuticals, Inc. and Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Millennium is responsible for commercialization of VELCADE in the U.S.; Janssen-Cilag is responsible for commercialization in Europe and the rest of the world. Janssen Pharmaceutical K.K. is responsible for commercial
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SOURCE Ortho Biotech
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