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Tumor Growth Inhibition and Pharmacokinetic Profile of NKTR-102 (PEG-Irinotecan) in Multiple Solid Tumors To Be Presented at Upcoming AACR-NCI-EORTC International Conference
Date:10/10/2007

International Conference on Molecular

Targets and Therapeutics at Moscone Center West in San Francisco,

California.

-- #C10 -- A poster presentation of preclinical data focused on tumor

growth inhibition of NKTR-102 in mouse xenograft models of colorectal,

lung and breast cancer;

-- #C157 -- A poster presentation of preclinical data focused on the

pharmacokinetics and pharmacodynamics of the active metabolite of

irinotecan following administration of NKTR-102 in mouse xenograft models

of lung and colorectal cancer.

The AACR-NCI-EORTC International Conference on Molecular Targets and Therapeutics Conference is an annual meeting of the American Association of Cancer Research (AACR), the National Cancer Institute (NCI) and the European Organization for Research and Treatment of Cancer (EORTC). More information

about the conference is available on the American Association of Cancer Research's website at:

http://www.aacr.org/home/scientists/meetings--workshops/molecular-targe ts-

and-cancer-therapeutics.aspx

About NKTR-102

Nektar is developing NKTR-102, a PEGylated form of irinotecan, which was invented by Nektar using its world-leading small molecule PEGylation technology platform. The product is currently in Phase 1 clinical development. Irinotecan is an important chemotherapeutic agent used for the treatment of solid tumors, including colorectal and lung cancers. By applying Nektar's small molecule PEGylation technology to irinotecan, NKTR-102 may prove to be a more powerful and tolerable anti-tumor agent.

More information on NKTR-102 and downloadable presentations of data for NKTR-102 are available at:

http://www.nektar.com/wt/page/nktr102media

Nektar PEGylation Platform

Nektar PEGyla
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SOURCE Nektar Therapeutics
Copyright©2007 PR Newswire.
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