Navigation Links
Trubion Pharmaceuticals Announces Presentation of Positive TRU-015 and SBI-087 Data at the 2008 Annual European Congress of Rheumatology Meeting
Date:6/16/2008

at the time of this assessment. Re-treatment with TRU-015 did not result in an increase in any adverse events compared with the initial infusion, and the re-treatment infusions were well-tolerated. B-cell depletion and recovery following re-treatment with TRU-015 was comparable to that seen after initial treatment. Ongoing patient evaluations showed maintenance of ACR responses following administration of a single dose of TRU-015 at six-month intervals.

Trubion announced in May that Wyeth had commenced patient dosing in the next Phase 2b clinical trial of TRU-015 in patients with RA. The randomized, parallel, double-blind, placebo-controlled, dose-regimen-finding study will evaluate the safety and efficacy of two dosing regimens. Treatment will be administered to approximately 216 patients with active, seropositive RA on a background of methotrexate. The primary outcome measurement for the TRU-015 Phase 2b study will be the ACR 50 response measured at 24 weeks. Secondary outcome measurements will be ACR 20 and Disease Activity Score-28 responses.

SBI-087 Demonstrates Favorable in Vivo B-Cell Depletion and Pharmacokinetic Profiles (THU0171)

SBI-087 is a humanized SMIP drug candidate that is directed against the CD20 antigen. The objective of the preclinical study conducted by Wyeth was to evaluate the pharmacokinetics and pharmacodynamics of SBI-087 following a single intravenous dose. Administration of SBI-087 resulted in dose-dependent B-lymphocyte depletion in peripheral blood and lymphoid tissues that was more profound and sustained in SBI-087-treated groups compared with rituximab.

In April, Trubion announced that Wyeth initiated a Phase 1 SBI-087 dose escalation clinical trial that is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single dose of SBI-087 in patients with RA. This Phase I trial is designed to enroll patients who meet the criteria for RA with Functional Class I, II or III, and
'/>"/>

SOURCE Trubion Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Trubion Announces Presentation of Positive TRU-016 Data at ASCO
2. Trubion Announces Initiation of Phase 2b Study of TRU-015 for the Treatment of Rheumatoid Arthritis
3. Trubion Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Rheumatoid Arthritis
4. Trubion Initiates Phase 1/2 Study of TRU-016 in CLL, Announces Next-Generation Product Candidate for RA and Provides Product Pipeline Update
5. Trubion Announces Initiation of Phase I/II Clinical Trial of TRU-015 for the Treatment of B-Cell Non-Hodgkins Lymphoma
6. Trubion Pharmaceuticals Announces Presentation of Positive Data From Phase IIb and Re-treatment Studies With TRU-015 in Patients With Rheumatoid Arthritis
7. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
8. Quatrx Pharmaceuticals Presents Results From Ophena(TM) (Ospemifene Tablets) Phase 3 Study Related to Treatment of Symptoms of Vulvovaginal Atrophy
9. Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association
10. European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals
11. Vion Pharmaceuticals Announces Presentation of Data of Cloretazine(R) (VNP40101M) in Elderly Patients with High-Risk Myelodysplastic Syndromes at the EHA Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com announces that ... catalogue: Baby Food Eastern Europe 2014 ... Food Eastern Europe 2014" is a new report by ... in Eastern Europe , key segments, ... This report also examines trends which are currently affecting ...
(Date:8/27/2014)... 2014 An experimental drug designed to help regulate ... treatment for anemia of inflammation, according to results from the ... today in Blood , the Journal of ... Anemia is a condition that occurs when red blood ... When an individual has anemia, the body does not get ...
(Date:8/27/2014)... , Aug. 27, 2014 North American lighting ... prestigious R&D 100 Award for the new OSRAM ITOS ® ... LED-based white light module for microscopy, endoscopy and surgical head ... with significantly higher efficacy and lamp life. "We,re ... one of the most innovative new technologies of the past ...
Breaking Medicine Technology:Baby Food Eastern Europe 2014 2Baby Food Eastern Europe 2014 3Baby Food Eastern Europe 2014 4Baby Food Eastern Europe 2014 5Baby Food Eastern Europe 2014 6Baby Food Eastern Europe 2014 7Baby Food Eastern Europe 2014 8Drug Represents First Potential Treatment for Common Anemia 2Drug Represents First Potential Treatment for Common Anemia 3OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 2OSRAM ITOS PHASER 3000 Laser and LED Light Module Recognized With Prestigious R&D 100 Award 3
... 10, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ... Annual J.P. Morgan Healthcare Conference on Thursday, January 13, 2011 ... being held at Westin St. Francis Hotel in San Francisco. ... will provide an overview of Anadys and its clinical development ...
... Mich., Jan. 10, 2011 Nopras Technologies, ... which specializes in services for organizations in the ... industries announced on January 10th, 2011 that it ... Nopras Technologies, well documented procedures and processes, ...
Cached Medicine Technology:Anadys Pharmaceuticals to Present at the J.P. Morgan Healthcare Conference 2Nopras Technologies, Inc. Achieves ISO 9001:2008 Certification 2
(Date:8/27/2014)... August 27, 2014 Dr. Stewart ... Center see multitudes of patients suffering from impaired vision. ... Cataract vision correction surgery . Recently, Dr. Shofner ... information during an eye exam and also online. To ... top five myths about glaucoma. , 1)    Myth: People with ...
(Date:8/27/2014)... August 27, 2014 The federal judge ... ) has extended the deadline for plaintiffs to enroll ... 2014 Order issued by U.S. District Judge David Katz ... enroll in the DePuy ASR Settlement Program must do ... Inc. ASR Hip Implant Products Liability Litigation – MDL ...
(Date:8/27/2014)... The extensive polling of 970 ... research group Black Book Rankings uncovers several alarming ... supplied or built to care for even a ... annual survey to gain stakeholder insight into the ... and emergency preparedness systems,” said Doug Brown, Managing ...
(Date:8/27/2014)... 2014 Ticket Down is a dependable source ... Life Stadium in Miami. The Brazilian national soccer team ... 5 at Sun Life Stadium in Miami Gardens, Florida. ... of the World Cup earlier this year when Brazil got ... The Brazilian Soccer Federation announced earlier this week that Neymar ...
(Date:8/27/2014)... -- There,s been controversy for years over whether the ... might raise the odds of mental health issues in ... 13,000 children finds no rise in the risk of ... while pregnant, but some data suggesting a heightened risk ... findings challenge prior research pointing to a link between ...
Breaking Medicine News(10 mins):Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 2Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 3Health News:Renowned Eye Surgeon Dr. Stewart Shofner Debunks Top Five Myths About Glaucoma 4Health News:DePuy ASR Settlement Enrollment Deadline Extended Until September 30, 2014, Bernstein Liebhard LLP Reports 2Health News:DePuy ASR Settlement Enrollment Deadline Extended Until September 30, 2014, Bernstein Liebhard LLP Reports 3Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 2Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 3Health News:American Hospitals Are Vastly Unprepared for Ebola Patients, Reveals Black Book™ Survey of Emergency Physicians, Nurses and Infection Control Practitioners 4Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 2Health News:Brazil vs. Colombia Tickets in Miami, FL: Ticket Down Cuts Ticket Prices on World Cup Rematch of Colombia vs. Brazil at Sun Life Stadium in Miami on Sept. 5th 3Health News:Do Antidepressants in Pregnancy Raise Risks for Mental Woes in Kids? 2Health News:Do Antidepressants in Pregnancy Raise Risks for Mental Woes in Kids? 3
... 28 (HealthDay News) -- Increasing one,s physical activity routine ... patients, Swedish researchers report. Vigorous activity can also ... the researchers said. The authors noted that IBS ... 15 percent of people around the world, and is ...
... help preserve the voice and vocal cord function for ... to a study from Henry Ford Hospital in Detroit. ... laryngeal squamous cell carcinomas, offering patients a less invasive ... preserving the voice," says study co-author Vanessa G. Schweitzer, ...
... News) -- People who have suffered a frontal brain ... and new research shows that people diagnosed as psychopathic ... suggests that psychopaths may benefit from therapy similar to ... the researchers at the University of Haifa in Israel. ...
... , FRIDAY, Jan. 28 (HealthDay News) -- A new ... work better in people with high levels of a certain protein ... Researchers found that the drugs work the same -- at ... diabetics -- regardless of the results of a test that looks ...
... of Naval Research,s (ONR) TechSolutions department is set to ... year new protective eyewear that will eliminate the need ... to accommodate differences in light levels. The Fast-Tint ... commonly found at an optometrist,s office. "Transition time is ...
... Dennis Thompson HealthDay Reporter , FRIDAY, Jan. 28 (HealthDay ... hospice doesn,t mean you die on anyone else,s timetable. Dennis, ... years ago, after she was diagnosed with a fatal heart condition. ... live. "The illness, the heart condition that I have, is ...
Cached Medicine News:Health News:Exercise Helps Ease Irritable Bowel Symptoms 2Health News:Voice-saver: Light therapy for early-stage laryngeal cancer 2Health News:Voice-saver: Light therapy for early-stage laryngeal cancer 3Health News:Blood Protein Level May Not Influence Effectiveness of Statins 2Health News:ONR's TechSolutions providing SEALs with new glasses that change lens color on the fly 2Health News:Woman's Life Refutes a Hospice Myth 2
Modified Freer periosteal elevator, #163, slight curve, 21 cm....
Williger periosteal elevator, 6 1/4", sharp, 5 mm wide....
Alley periosteal elevator, extra long, 21 cm, 8-1/4"....
Periosteal elevator #9H, 17.5 cm, 7"....
Medicine Products: