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Trubion Pharmaceuticals Announces Presentation of Positive TRU-015 and SBI-087 Data at the 2008 Annual European Congress of Rheumatology Meeting
Date:6/16/2008

SEATTLE, June 16 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals Inc. (Nasdaq: TRBN) today announced presentation of data at the 2008 Annual European Congress of Rheumatology meeting in Paris demonstrating that repeat administration with TRU-015, Trubion's lead candidate for the treatment of rheumatoid arthritis (RA), continues to produce persistent responses on the American College of Rheumatology (ACR) criteria and consistent pharmacodynamic (PD) effects. In addition, preclinical data presented at the meeting demonstrated that a single dose of SBI-087, a next-generation Small Modular ImmunoPharmaceutical (SMIP(TM)) treatment for RA, resulted in more potent B-cell depletion in peripheral blood and lymphoid tissues than rituximab. Wyeth Pharmaceuticals is developing TRU-015 and SBI-087 in collaboration with Trubion.

Repeated Therapy With TRU-015 Is Well-Tolerated With Consistent PD Profile (OP-0252)

The objective of the ongoing re-treatment study was to evaluate the safety, PD, pharmacokinetics and immunogenicity of TRU-015 for RA with repeated doses after receiving initial administration in a Phase I/IIa study. Patients treated with a single course of 5 mg/kg or higher in a previously conducted TRU-015 Phase I/IIa study were eligible for re-treatment. Patients who received a single infusion of 5 mg/kg received a single infusion of 5 mg/kg upon re-treatment, and those who received higher doses of TRU-015 received a single infusion of 15 mg/kg upon re-treatment. PD response of B-cells was also evaluated after initial treatment and after re-treatment.

Thirty-eight patients have entered the re-treatment study, and re-treatment data were available for 36 patients with some patients having received six courses of TRU-015
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SOURCE Trubion Pharmaceuticals Inc.
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