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Trubion Announces Presentation of Positive TRU-016 Data at ASCO
Date:6/2/2008

TRU-016 Produces Significant Anti-Tumor Activity and Long-Term Tumor

Regression in Pre-Clinical Studies

SEATTLE, June 2 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals Inc. (Nasdaq: TRBN) today announced presentation of positive pre-clinical data showing that Trubion's TRU-016 has potent anti-tumor activity and induces significant long-term tumor eradication in a human tumor xenograft model in which rituximab failed to induce durable responses. TRU-016 is Trubion's proprietary CD37-targeted therapy in development for B-cell malignancies such as chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL).

ASCO Abstract 3074

TRU-016, a small modular immunopharmaceutical (SMIPTM) candidate, targets the CD37 antigen on human B cells. Data from both in vivo and in vitro studies presented at the American Society of Clinical Oncology (ASCO) 2008 Annual Meeting showed TRU-016 has potent anti-tumor activity and induces significant long-term tumor eradication in a human tumor xenograft model in which rituximab failed to induce durable responses. Moreover, TRU-016 treatment produced anti-tumor activity that resulted in increased survival and a significant delay in tumor growth in NHL xenografts.

These data were presented during a poster session at the ASCO Annual Meeting on June 1, 2008, from 2-4 p.m. CDT. The poster is available on the investor section of Trubion's Web site: http://investors.trubion.com/events.cfm.

"Data from this study, combined with data from previous studies, reinforce our belief that TRU-016's novel mechanism of action may provide patients with a potent new therapeutic option for the treatment
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SOURCE Trubion Pharmaceuticals Inc.
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