Navigation Links
Trubion Announces Initiation of Phase 1 Study of SBI-087 for the Treatment of Rheumatoid Arthritis
Date:4/21/2008

First Patient Dosed in Phase 1 Trial of SBI-087, Trubion's Next-Generation

Candidate

SEATTLE, April 21 /PRNewswire-FirstCall/ -- Trubion Pharmaceuticals Inc. (Nasdaq: TRBN) today announced that its collaboration partner Wyeth Pharmaceuticals, a division of Wyeth (NYSE: WYE), has initiated a Phase 1 clinical trial of SBI-087, a next-generation drug candidate for the treatment of rheumatoid arthritis (RA). In collaboration with Trubion, Wyeth Pharmaceuticals is developing SBI-087 and other CD20-directed products. SBI-087 for RA builds on Trubion and Wyeth's clinical experience with Trubion's lead compound, TRU-015, and is based on Trubion's Small Modular ImmunoPharmaceutical (SMIP(TM)) technology.

The Phase 1 SBI-087 dose escalation clinical trial is designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of a single dose of SBI-087 in patients with RA. Preclinical research suggests that SBI-087, a fully humanized CD20-directed SMIP, has enhanced potency in B-cell depletion in vivo compared with Rituxan. This Phase 1 trial is designed to enroll patients who meet the criteria for RA with Functional Class I, II or III, and who have been diagnosed with RA more than six months prior to the study with onset of RA after the age of 16.

With SBI-087, Trubion's pipeline now includes two differentiated compounds under development for the treatment of autoimmune and inflammatory diseases: TRU-015 and SBI-087. Trubion and Wyeth are leveraging Trubion's
'/>"/>

SOURCE Trubion Pharmaceuticals Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Trubion Announces Preliminary Analysis of Phase IIb Results With TRU-015 in Rheumatoid Arthritis
2. Trubion Pharmaceuticals Announces Presentation of Positive Data From Phase IIb and Re-treatment Studies With TRU-015 in Patients With Rheumatoid Arthritis
3. Trubion Announces Initiation of Phase I/II Clinical Trial of TRU-015 for the Treatment of B-Cell Non-Hodgkins Lymphoma
4. Trubion Initiates Phase 1/2 Study of TRU-016 in CLL, Announces Next-Generation Product Candidate for RA and Provides Product Pipeline Update
5. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
6. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
7. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
8. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
9. DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947
10. Phosphagenics Announces Positive Phase 1b Transdermal Insulin Clinical Trial Results
11. Xenomics Announces Implementation of its First Diagnostic Test for Acute Myeloid Leukemia Into Clinical Practice
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... 22, 2014  Sprout Pharmaceuticals today announced positive preliminary results ... treated with flibanserin up to 200 mg at bedtime had ... at the 20 th Annual Fall Scientific Meeting of ... in Miami . The ... Complete Response Letter and the Formal Dispute Resolution that was ...
(Date:11/22/2014)... , Nov. 21, 2014 Statistics released from ... drunk driving increase astronomically during the holidays, beginning with ... many cities. The data, highlighted ... Systems as part of their annual Sober ... a picture of high-risk drinking and increased rates of ...
(Date:11/21/2014)... 21, 2014  Alere Inc. (NYSE: ALR ... appointed Juliet Cunningham as Vice President, Investor ... responsible for driving communications with the investment community. ... of changes to increase shareholder value, it is critical ... Namal Nawana, Chief Executive Officer. "We are delighted that ...
Breaking Medicine Technology:Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 2Sprout Pharmaceuticals Presents Phase 1 Clinical Trial Data Showing Treatment With Flibanserin Results In No Next-Day Driving Impairment 3Alarming Stats Show Holiday Drinking an Issue for Many 2Alere Appoints Juliet Cunningham to Lead Investor Relations 2
... - Arrowhead,Research Corporation (NASDAQ:ARWR) announced today that,majority-owned ... Proceedings of the National Academy of Sciences,(PNAS) ... use multiple,systemic dosing with Calando's lead siRNA ... technologies in targeted,polymeric delivery systems and siRNA ...
... in Two Most Common Mutations, CRANBURY, N.J., ... biopharmaceutical company developing small,molecule, orally-administered pharmacological chaperones ... genetic diseases, announced today,that it will present ... tartrate, AT2101) for Gaucher disease at,the of ...
Cached Medicine Technology:Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on,Targeted, Systemic Delivery of siRNA 2Arrowhead Subsidiary, Calando Pharmaceuticals Publishes Study on,Targeted, Systemic Delivery of siRNA 3Amicus Therapeutics Presents Preclinical Data from Studies of,Plicera for Gaucher Disease 2Amicus Therapeutics Presents Preclinical Data from Studies of,Plicera for Gaucher Disease 3
(Date:11/24/2014)... (PRWEB) November 24, 2014 "My friend ... was trying to cross the street in his motorized ... never saw him. I came up with this idea ... at night." , He developed the Safety Lites to ... in low-lighting conditions. The device ensures that motorists can ...
(Date:11/23/2014)... For the coming special Friday, Tidebuy, a famous wedding ... for many products, especially the beautiful colored wedding dresses ... with amazing discounts, up to 90% off. Don’t hesitate ... easy to buy colored wedding dresses in different sizes ... famous for delicate craftsmanship, elegant style and perfect lines. ...
(Date:11/23/2014)... 23, 2014 Pro Ace Care, a renowned ... will now be providing an 8 year warranty on its ... tank installations went up due to the impending winter season, ... customers of the premium service that the company provides. As ... warranty on John Wood and Bradford hot water tanks. ...
(Date:11/23/2014)... 23, 2014 (HealthDay News) -- The holidays can be ... sensory overload can trigger major meltdowns, an expert says. ... best of circumstances, but when you have children with ... an occupational therapy professor at University of the Sciences ... "It,s best to let your hosts or visitors know ...
(Date:11/23/2014)... 2014 To show thanks to new and ... of white evening dresses for weddings. Customers who ... , iFitDress.com is a distinguished dress manufacturer, and it is ... worldwide customers for a very long time. The CEO of ... customer will be able to buy not only a beautiful ...
Breaking Medicine News(10 mins):Health News:Beautiful Wedding Dresses Available at Popular B2C Company Tidebuy 2Health News:Pro Ace Care Now Gives 8 Year Guarantee on Selected Vancouver Hot Water Tanks 2Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:iFitDress.com: Wonderful White Evening Dresses Now Available 2
... have an exciting,new fitness option for their children this ... of the "Ultimate Fitness" program for 3 - 18 ... on the priority list of,Manhattan parents as childhood obesity ... will keep their children engaged and excited about,physical activity. ...
... Ranked Among Inc. ... NEW YORK and SAN FRANCISCO, Sept. 5 WeissComm ... announced 10 recent new hires to work on several new ... offices. The Company also announced that the 2007 survey ...
... Patient Forecast Projects Significant Expansion of Drug-Treated Population, But ... to a New ... Report from Decision Resources, WALTHAM, Mass., Sept. 5 ... on pharmaceutical and,healthcare issues, has found that a significant proportion of ...
... Succulent Morsels Paired with Delectable Sauces Satisfy Even the Most ... ... taste in mind and,health at heart, the Wellness(R) brand of natural ... Wellness(R) Healthy Indulgence,Naturally Delicious Everyday Entrees. Pairing savory sauces with real,seafood ...
... bibs, led is a top concern for parents. The problem for,parents ... Now what do I,buy? How do I keep my child clean ... 5 times everyday for meals/snacks during the first 4,years of a ... help of a Crumb Chum. Let Babies Soar!, LLC , ...
... , Alexander D. Wissner-Gross and Efthimios Kaxiras, Physical ... has shown that thin layers of ice could ... well above body temperature, which could make ice-coated-diamond ... joint replacements, and wear-resistant prosthetics. , , Physicists Alexander ...
Cached Medicine News:Health News:Keeping Kids Healthy and Fit: The New York Kids Club Launches a Revolutionary New Fitness Program 2Health News:WeissComm Partners Makes 10 New Hires as It Wins New Accounts and Grows Existing Business 2Health News:Burgeoning Population of Hepatitis C Virus Patients in Need of Second- and Third-Line Treatment Options 2Health News:Finicky Felines Award Four Stars to New Wellness(R) Healthy Indulgence Everyday Entrees 2Health News:Finicky Felines Award Four Stars to New Wellness(R) Healthy Indulgence Everyday Entrees 3Health News:Mother and Daughter Create Lead-Free/Safe Bibs and Solve Messy Mealtime Problems 2Health News:Hot ice, measuring depression, perfect invisibility and flu vaccine incentives 2Health News:Hot ice, measuring depression, perfect invisibility and flu vaccine incentives 3Health News:Hot ice, measuring depression, perfect invisibility and flu vaccine incentives 4
Corneal rust ring remover battery powered, extra burr 1.0 mm....
BD Visitec IOL Manipulator (Lester), 0.25 mm diameter tip angled 45 in, 10 mm from end (3/bx, 1 bx/ca), sterile. For positioning intraocular lenses. Sure grip handles hand ridge indicating position o...
Sinskey lens manipulator, straight. Also available in titanium....
ICL manipulator with textured micro-ball tip....
Medicine Products: