Navigation Links
Trius' Torezolid Antibiotic for the Treatment of Severe Skin Infections Featured at ICAAC Meeting
Date:9/12/2009

SAN DIEGO, Sept. 12 /PRNewswire/ -- Trius Therapeutics, Inc. announced today that 13 posters will be presented at the 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) supporting the potency, efficacy and safety of torezolid as a potential new antibiotic for the treatment of severe skin infections caused by gram positive bacteria including MRSA. Additional data from a previously announced Phase 2 study of torezolid (TR-701) reiterate the high efficacy of torezolid at the low 200 mg dose against methicillin-sensitive and methicillin-resistant bacteria in patients with severe complicated skin and skin structure infections (cSSSI). In vitro studies presented at ICAAC highlight the potency of torezolid against linezolid-resistant MRSA and cfr-mediated resistant bacteria.

"The package of data Trius is presenting at ICAAC provides compelling evidence of the high efficacy of torezolid against difficult to treat bacterial skin infections, including potency against bacterial strains proven to be resistant to linezolid," said Philippe Prokocimer, M.D., chief medical officer at Trius." There is an urgent need for more potent antibiotics like torezolid with different mechanisms of action that can circumvent drug resistance pathways."

ICAAC data presentations are as follows:

Saturday, September 12

(Poster Session 024, 11:30 am - 1:30 pm)

  • L1-335/355: Safety and Efficacy of TR-701 in a Phase 2 Randomized, Double-Blind Study in Patients with Severe Complicated Skin and Skin Structure Infections (cSSSI)

(Poster Session 004, 11:30 am - 1:30 pm)

  • B-050/52: Comparative Efficacy of TR-701, Vancomycin (Vanco), and Daptomycin (Dapto) in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus (MRSA) Endocarditis

Sunday, September 13

(Poster Session 082a, 11:15 am - 1:15 pm)

  • E-808/275: Activity of Torezolid against linezolid-resistant MRSA strains with cfr gene mediated resistance
  • E-807/274: Comparative Activity of TR-700 Against Staphylococci Blood Isolates Collected in Spain
  • E-809/276: In Vitro Activity of Torezolid (TR-700) versus Linezolid against Chlamydia species

Monday, September 14

(Poster Session 155, 11:15 am - 1:15 pm)

  • C1-1346/84: Unexpectedly low cost of fitness associated with acquisition of the cfr resistance gene
  • C1-1364b/104: Genetic Environment and Instability of cfr in MRSA CM05
  • C1-1364a/103: In vitro Activity of TR-700 (Torezolid) and Linezolid against Gram-positive Clinical Isolates from a Phase 2 Complicated Skin Clinical Trial
  • C1-1349/87: Mutations in Ribosomal Protein L3 are Associated with Oxazolidinone Resistance in Staphylococci of Clinical Origin

Tuesday, September 15

(Poster Session 226, 9:00 am - 11:00 am)

  • A1-1939/12: Compararative Pharmacodynamics of a Novel Oxazolidinone, TR-701, Against S. aureus in a Neutropenic Murine Pneumonia Infection Model
  • A1-1935/8: Defining the Impact of Granulocytes (G) on the Kill of Methicillin-Resistant Staphylococcus aureus (MRSA) by the New Oxazolidanone Prodrug TR-701
  • A1-1947/20: Evaluation of Tissue Distribution of TR-700 in Healthy Volunteers, Using Microdialysis
  • A1-1934/7: Torezolid (TR-700), a novel methyltetrazolyl-oxazolidinone, accumulates markedly within human THP-1 macrophages and shows activity towards intraphagocytic Legionella pneumophila: comparison with linezolid

Copies of these posters will be available on the Trius Web site following the ICAAC meeting.

About Trius Therapeutics

Trius Therapeutics is discovering and developing innovative antibacterial drugs for the treatment of infections caused by drug-resistant pathogens. The company's lead drug candidate, torezolid, is a second generation oral and IV oxazolidinone antibiotic with potent activity against drug-resistant, gram-positive bacterial pathogens including those resistant to linezolid, the only currently marketed antibacterial drug of the oxazolidinone class. Trius' pipeline includes two preclinical programs with lead candidates for serious infections caused by gram-negative bacterial pathogens. For more information, visit www.triusrx.com.


'/>"/>
SOURCE Trius Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections
2. Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases
3. Trius Completes Enrollment in Phase 2 Clinical Trial Evaluating Torezolid (TR-701) in Patients With Complicated Skin and Skin Structure Infections
4. Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA
5. Trius Doses First Patient in Antibacterial Phase 2 Trial
6. PacificGMP Completes GMP Product Fill for Trius Therapeutics
7. Trius Initiates U.S. Phase I Trial for its Oxazolidinone Antibacterial Drug, TR-701
8. Childrens Hospital Receives Six-Year Federal Contract to Study Antibiotic Use in Children With Urinary Tract Infections
9. NovaBay Launches Clinical Study for Non-Antibiotic Treatment of Impetigo, One of the Most Common Skin Infections
10. Calixa Therapeutics Announces Initiation of Phase 2 Clinical Trial of Its Antibiotic, CXA-101, in Patients with Complicated Urinary Tract Infections
11. Rib-X Pharmaceuticals Novel Antibiotic Delafloxacin Named One of R&D Directions 100 Great Investigational Drugs of 2009
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2017)... YORKTOWN, N.Y. and EDMONTON, ... IBM ) scientists and the University of ... have published new data in Nature,s partner journal, ... learning algorithms helped predict instances of schizophrenia with ... technology predicted the severity of specific symptoms in ...
(Date:7/20/2017)... PAUL, Minn. , July 20, 2017  Prime Therapeutics ... Jonathan Gavras , M.D., following today,s Institute for Clinical ... report on the effectiveness and value of abuse-deterrent ... manager on the policy roundtable at the meeting. ... is not a material cost benefit to the use of ...
(Date:7/14/2017)... Endo International plc (NASDAQ: ENDP ) will announce its ... its senior management team will host a conference call and webcast ... The dial-in number to access the call is U.S./ ... passcode is 45397076. Please dial in 10 minutes prior to the ... replay of the call will be available from August 8, 2017 ...
Breaking Medicine Technology:
(Date:7/23/2017)... (PRWEB) , ... July 23, ... ... Eating Disorders Professionals ™(iaedp), the leading provider of education and training standards ... in preparation for competency for Traditional Certification: the iaedp™ Core Curriculum. , ...
(Date:7/23/2017)... ... 23, 2017 , ... Scientists from the University of Exeter reported ... weight-bearing activity equivalent to a medium-paced run for pre-menopausal women, or a slow jog ... in total spine care, I understand the importance exercise can play on improving bone ...
(Date:7/23/2017)... TORONTO, ONTARIO, CANADA (PRWEB) , ... July 23, 2017 , ... ... as a way to gain that elusive college scholarship or even go on to ... Sports Medicine’s Annual Meeting in Toronto, Canada today say “not so fast.” ...
(Date:7/23/2017)... ... , ... “I Am Not Nothin’: The Serpent Handler’s Daughter” is a compelling ... write and a brokenhearted young soldier who turned to whiskey after his return from ... power of simple faith is the work of published author Tommy G. Robertson, a ...
(Date:7/23/2017)... ... July 23, 2017 , ... “Squiggy’s Outdoor Adventure”: a turtle’s backyard adventure that ... of published author, Paula Christian, a wife and mother to three amazing, and supportive, ... center their lives on God. She loves to tell stories to her children, ...
Breaking Medicine News(10 mins):