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Trius Reports New Findings on Mechanisms of Antibiotic Resistance in MRSA
Date:9/13/2010

erentiates it as a true second generation oxazolidinone which may be a solution to emerging linezolid resistance."

The AAC manuscripts are available to subscribers ahead of print at: http://aac.asm.org/papbyrecent.dtl.

Structure-Activity Relationships of Diverse Oxazolidinones for Linezolid-Resistant Staphylococcus aureus Strains Possessing the cfr Methyltransferase Gene or Ribosomal  Mutations

Jeffrey B. Locke, John Finn, Mark Hilgers, Gracia Morales, Shahad Rahawi, Kedar GC, Juan Jose Picazo, Weonbin Im, Karen Joy Shaw, and Jeffrey L. Stein

Antimicrob. Agents Chemother. published ahead of print on 13 September 2010

Elevated Linezolid Resistance in Clinical Staphylococcus aureus cfr Isolates is Associated with Co-occurring Mutations in Ribosomal Protein L3

Jeffrey B. Locke, Gracia Morales, Mark Hilgers, Kedar GC, Shahad Rahawi, Juan José Picazo, Karen Joy Shaw, and Jeffrey L. Stein

Antimicrob. Agents Chemother. published ahead of print on 13 September 2010

The results in these AAC articles are also featured in two poster presentations given at this year's ICAAC conference on September 14 (posters C1-1431 and C1-1432; Session 170; 11:15AM – 1:15PM). Trius presented a total of 12 posters at ICAAC highlighting the latest findings from its antibiotic research programs, including preclinical research on antibiotics targeting Gyrase B/ParE and dihydrofolate reductase (DHFR). Copies of all posters are available on the Trius website at: http://www.triusrx.com/trius-therapeutics-news-posters-publications-year.php.  

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Refor
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SOURCE Trius Therapeutics, Inc.
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