Navigation Links
Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections
Date:6/8/2009

t Regional Research Group, Columbus, GA, a clinical investigator of the Phase 2 study. "The nature of such infections usually warrants use of an IV antibiotic, but the trial results indicate that oral torezolid successfully treated these severe infections quickly and effectively."

"We set strict severity criteria for enrollment to ensure that patients had a clear need for systemic antibiotic therapy," said Philippe Prokocimer, M.D., Chief Medical Officer of Trius. "Two-thirds of the patients treated had systemic signs of infection, such as fever or elevated white blood cell counts. The fact that the lowest dose of 200 mg was as efficacious as the higher doses also provides for a broad safety margin. In our prior 21-day Phase 1 clinical trial, which examined hematological parameters as key markers of oxazolidinone safety, the 200 mg dose of torezolid was comparable to placebo while the labeled dose of linezolid produced the expected depletion of platelets and other cell lines. It is also encouraging that the efficacy of the 200 mg dose in patients is consistent with the dose predictions based on animal efficacy studies. Collectively, these data enable us to select the 200 mg dose for our Phase 3 pivotal trials in complicated skin and soft tissue infections."

Torezolid was well tolerated by patients in this Phase 2 trial. Treatment-emergent adverse events related to study drug, 92% of which were assessed as mild, occurred in 35%, 52% and 50% of subjects in the 200, 300 and 400 mg dose groups, respectively. Importantly, there were no study discontinuations due to adverse events. Laboratory results showed no significant shifts from baseline in hematology or chemistry parameters, including platelets or liver enzymes.

"The efficacy and safety of torezolid in this trial demonstrate its potential for the rapid treatment of severe infections caused by Staph aureus, including MRSA, in both the community and the hospit
'/>"/>

SOURCE Trius Therapeutics, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases
2. Trius Completes Enrollment in Phase 2 Clinical Trial Evaluating Torezolid (TR-701) in Patients With Complicated Skin and Skin Structure Infections
3. Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA
4. Trius Doses First Patient in Antibacterial Phase 2 Trial
5. PacificGMP Completes GMP Product Fill for Trius Therapeutics
6. Trius Initiates U.S. Phase I Trial for its Oxazolidinone Antibacterial Drug, TR-701
7. Merz Pharmaceuticals Announces Results of Clinical Trials with NT-201(Botulinum neurotoxin type A free from complexing proteins) at Annual Movement Disorders Society Meeting
8. Lilly Announces Positive Phase II Data on Investigational Medicine for Patients with Type 2 Diabetes
9. Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk
10. Access Pharmaceuticals Announces Publication of Thiarabine Combination Data
11. Cardiogenesis Announces Presentation of its PHOENIX(R) Combination TMR Plus Stem Cell Delivery System at the International Society of Minimally Invasive Cardiothoracic Surgeons (ISMICS) Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has repositioned ... market share and grab a foothold in the hydroponic, hemp ... capabilities and a presence in the sector, and recently partnering ... growth of hemp and medical marijuana, iMD is committing to ...
(Date:1/23/2015)... LAS VEGAS , Jan. 23, 2015 Cord Blood ... CBAI ) ("CBAI" or the "Company")  filed a Preliminary Proxy ... ( www.sec.gov ) today, and provides an update for shareholders ... authorized shares is requested. Dear Shareholders, ...
(Date:1/23/2015)... JUNCTION, N.J. , Jan. 23, 2015  CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... patients, announced the receipt of $385,642, net of ... participant of the Technology Business Tax Certificate Transfer ...
Breaking Medicine Technology:iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 2Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 3Cord Blood America Announces Preliminary Proxy Filing and Details Why a "YES" Vote to Increase Authorized Shares Is Requested 4CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3
... May 18 TriLink BioTechnologies, ... service agreement with Osmetech Molecular Diagnostics to supply ... Carrier Detection (CFCD) System and the eSensor(R) XT-8 ... TriLink is providing Osmetech with custom oligonucleotides, which ...
... 18 DSM announced today that its proprietary ... mammalian cell culture processes by 5-10 fold for ... at the R&D labs of DSM Biologics in ... CHO-based cell cultures can be increased 5-10 fold ...
Cached Medicine Technology:TriLink BioTechnologies, Inc. Announces Supply Agreement With Osmetech Molecular Diagnostics 2DSM Announces Yield Boosts of 5-10 Fold With XD(R) Technology for Mammalian Manufacturing Platforms 2DSM Announces Yield Boosts of 5-10 Fold With XD(R) Technology for Mammalian Manufacturing Platforms 3
(Date:1/22/2015)... Juvent Sports ( http://www.juventsports.com ) and David ... Show to bestow a Juvent Sports Achievement award upon ... McKitrick. The award commemorated and congratulated McKitrick for her ... won her first amateur tournament in 1979 and most ...
(Date:1/22/2015)... 2015 Autocarinsurancebest.com has released a new blog ... auto insurance policy . , Auto insurance quotes help ... is no longer necessary to call an agent or visit ... online on a single website: http://autocarinsurancebest.com/ . , Every ...
(Date:1/22/2015)... Plainsboro, NJ (PRWEB) January 22, 2015 ... advocate and keynote speaker at the upcoming 32nd ... by ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , ... breast would have gone undetected if she had not ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 Recently, Weddingshe.com has ... catalog, and has announced its highest annual revenues in the ... on its popular glamorous wedding dresses. , According to the ... important wedding dress promotions for them in 2015. This point ...
(Date:1/22/2015)... WASHINGTON, DC (PRWEB) January 22, 2015 ... conditions in vulnerable communities and cause financial distress to ... report by analysts at Howard University’s Center on Race ... of dollars in economic activity, payday loans at the ...
Breaking Medicine News(10 mins):Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Commercial Auto Insurance Provides Several Important Features! 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:Weddingshe Announces A Special Offer On Its Popular Glamorous Wedding Dresses 2Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2
... Derek Kirchen, 67, who had suffered pneumonia eight times and ... their wits end, making sense of the symptoms and providing ... clues, doctors had cautioned Kirchen that the symptoms may be ... surgery, Dr Syed Tariq, a respiratory physician, stumbled upon a ...
... using dummy due to different developmental, hygienic or aesthetic reasons. ... dummies are bad for babies and parents should be in ... 20 studies conducted over the world since from past decade ... dummies are prone to reject or breastfeed for a shorter ...
... We might feel that we have forgotten certain things in ... that whatever we have forgotten does still stay in our ... and Roberto Cabeza of Duke University, conducted a study in ... we think it, does. According to the online edition of ...
... May that one adult and two children have been diagnosed with ... statement confirming that there have been three linked cases of E.coli ... these cases have a link with J&H Cairns, a butcher in ... no conclusive evidence yet that J&H Cairns is the source of ...
... UN sponsored conference on aviation flu has called ... facility involving all relevant institutions across the globe, ... bird watchers and wildlife conservation societies to check ... ,Scientists attending the conference convened by the UN ...
... led young people to name heroin as a loser ... which includes providing alternative narcotics and needle exchange programs, ... to consider the substance ‘loser drug,’ a Lancet study ... in Zurich said: The policy provides an alternative narcotics ...
Cached Medicine News:Health News:Diagnosis On a Fourth Patient Confirmed To Be E.Coli 2
... Repair System is an evolutionary product for ... Although initially designed specifically for use with ... is quickly becoming a new standard for ... system includes a unique method to deliver ...
... Tunnel Release System is a technological breakthrough ... using a minimally-invasive approach, provides significant patient ... base of the wrist,creates an entry for ... to a standard video camera system, provides ...
... a safe alternative to using positive displacement ... such as PCR(a), pipetting radioactive materials and ... excellent for tissue culture, gel loading, serological ... aerosol contaminants and liquids from reaching the ...
... orifice tip, the Finntip Wide is designed ... macromolecules like genomic DNA. This tip eliminates ... It is excellent for use with extremely ... inside diameter of the orifice is 1.1 ...
Medicine Products: