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Trevena Granted Key Composition of Matter Patent for TRV027 in U.S.
Date:7/17/2013

a Phase 2a study on the hemodynamic effects of TRV027 in patients with advanced heart failure with reduced ejection fraction (NCT01187836), as a poster at the American College of Cardiology meeting in March 2013. The Phase 2a trial was an ascending dose titration study in patients with stable NYHA Class 3 or 4 heart failure.   

About ADHF
The American Heart Association estimates that ADHF hospitalization costs the U.S. healthcare system more than $20 billion each year in direct spending.  ADHF is already the leading reason for hospitalization of individuals over 65 years old in the United States, with more than 1 million hospital admissions per year.  ADHF is also the most costly diagnosis for Medicare in the nation.  Despite the significance of this problem, current therapies are not producing meaningful improvements in patient outcomes.  ADHF incidence is increasing globally, and both heart failure mortality and hospital re-admission following an ADHF event remain extremely high.

About Trevena
Trevena, Inc. is a clinical stage pharmaceutical company focused on discovering and developing the next generation of GPCR targeted medicines.  GPCRs are the targets for at least one-third of modern medicinal products, and remain the predominant class of targets under clinical evaluation.  Trevena's expertise lies in engineering "biased ligands" that activate only the beneficial signaling pathways downstream of a GPCR to unlock new biology and avoid drug adverse effects.  In addition to TRV027, Trevena's pipeline currently includes a clinical stage mu-opioid biased ligand for post-operative pain, and earlier-stage programs for chronic pain, and Parkinson's disease.  For more details, visit www.Treve
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SOURCE Trevena, Inc.
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