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Trevena Appoints Roberto Cuca as Senior Vice President & Chief Financial Officer
Date:9/17/2013

/>GPCRs are the targets of at least one-third of modern medicinal products, and remain the predominant class of targets under clinical evaluation.  However, traditional ligands either turn on, or turn off, all of the signaling pathways engaged by a particular receptor, which can result in efficacy limitations or undesirable adverse effects. Trevena's expertise lies in engineering "biased ligands" that activate only the beneficial signaling pathways downstream of a GPCR to unlock new biology and avoid drug adverse effects.

About Trevena
Trevena, Inc. is a privately held, clinical stage pharmaceutical company that has built a pipeline of biased GPCR ligands to address unmet medical needs in cardiovascular, pain and other CNS conditions.  The company's drug discovery technology is based on extensive research from the laboratory of Nobel Prize winning scientist Robert J. Lefkowitz, M.D. of Duke University Medical Center. The lead drug in Trevena's portfolio, TRV027, is a first-in-class agent in Phase 2 testing for the treatment of acute heart failure. TRV027 is being developed by Trevena under a recently announced collaborative licensing option agreement with Forest Laboratories Inc. (NYSE: FRX). Trevena's pipeline also includes a clinical stage mu-opioid biased ligand, TRV130, in development for post-operative pain, a pre-clinical program for chronic pain, and discovery-stage programs for pain and Parkinson's disease. Trevena is based in King of Prussia, Pennsylvania and is backed by Alta Partners, Healthcare Ventures, NEA, Polaris, Forest Holdings and Yasuda Enterprise Development Company.  For more information about the company, please visit www.trevenainc.com.

For more information, please contact:
Ros Deegan, VP Business Development, Trevena Inc., 610-354-8840 x225 (Corporate)
Kimberly Minarovich, C
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