Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Admi... (transition transition procedure dose tit...)

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Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration

Date:5/21/2008

transition, transition procedure, dose titrations and clinical outcomes. The primary reason for transition in all patients was worsening PAH, with non-compliance with the Ventavis dosing regimen reported as a secondary reason for transition. Most patients transitioned to Remodulin in an inpatient setting, but many patients were successfully transitioned at home with the assistance of an infusion nurse. The authors reported that 6MW distances were maintained post-transition, no serious adverse events occurred due to the switch, and adverse events were consistent with known prostacyclin side effects.

In Long-Term IV Treprostinil in Pediatric PAH, Dr. Cherise Rowan of the Columbia University Medical Center presented data from an independent retrospective chart review of 16 pediatric patients transitioned from Flolan to Remodulin between 2004 and 2007. Based on clinical observations and hemodynamic data, the authors of this analysis concluded that transition of children with stable PAH from long-term intravenous Flolan to intravenous Remodulin appears safe with efficacy maintained.

Subcutaneous Treprostinil

In Subcutaneous Treprostinil for Severe PAH: Hemodynamic and Clinical Outcomes Discussion, Dr. Francisco J. Soto of the Medical College of Wisconsin presented independent data from a cohort of 52 PAH patients receiving subcutaneous Remodulin over a period of 5 years. He noted that substantial improvements were seen in hemodynamics, 6MW distance, BNP and NYHA functional class at an average duration of more than one year. Key success factors in the response with subcutaneous Remodulin included rapid dose escalation to a minimum target of 40 ng/kg/min, infrequent subcutaneous catheter site changes, and proactive pain management. The authors conclude that once patients overcome the initial obstacles of subcutaneous administration of Remodulin (e.g., infusion site pain), they tolerate treatment very well and sustain durable clinical and hemodynamic be
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