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Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration
Date:5/21/2008

istered to each patient showed a linear correlation with total plasma exposure (AUC) and maximum exposure (Cmax). This is an important finding that supports the ability to reliably titrate oral treprostinil to therapeutic levels.

Intravenous Treprostinil

In Intravenous Treprostinil Effect on Angiopoietin-2 Levels During 12 Weeks of Blinded Therapy: a Study of 11 Biomarkers in PAH, Dr. R. James White presented results of his biomarker study demonstrating that intravenously administered treprostinil sodium (Remodulin(R)) decreased the presence of a specific protein that contributes to PAH -- Angiopoietin-2 -- in 12 of 13 patients. This study was part of the first randomized, placebo-controlled trial of an infused prostacyclin in patients with PAH. The primary endpoint of this randomized, placebo-controlled study, change in 6MW distance, showed an 83-meter improvement as compared to placebo.

In Treatment Effects Following Rapid Switch to IV Treprostinil in Stable PAH Patients, Dr. Omar A. Minai of the Cleveland Clinic presented data from an ongoing single-center, 8-week study of treatment satisfaction of PAH patients who switched from epoprostenol (Flolan(R)) to intravenous Remodulin. Rapid switch from Flolan to Remodulin occurred by directly switching the infusion pump reservoir. Dr. Minai reported that no patients experienced clinical deterioration or change in functional class, and he also observed a favorable impact on quality of life as early as 8 weeks following transition. He noted that time spent by patients on drug preparation decreased by 44 percent with Remodulin as compared to Flolan.

In Multi-Center Experience with Transition to Treprostinil from Inhaled Iloprost in PAH, Dr. Robert Frantz of the Mayo Clinic presented a retrospective chart review that evaluated best practices principally surrounding transitions from inhaled iloprost (Ventavis(R)) to intravenous Remodulin. Medical records were assessed to determine the reason for
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SOURCE United Therapeutics Corporation
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