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Treatment of Patients With Malignant Mesothelioma Utilizing Photodynamic Therapy With Pinnacle Biologics' Compound PHOTOFRIN® - Obtains FDA Orphan Drug Designation
Date:12/14/2011

PHOTOFRIN® is a two-stage process requiring administration of both drug and light. The first stage of PDT is the intravenous injection of PHOTOFRIN®. Illumination with non-burning laser light 40–50 hours following injection with PHOTOFRIN® constitutes the second stage of therapy. When injected, PHOTOFRIN® is attracted to and linger in certain tissues, especially cancer cells, and tumor destruction is by biochemical reactions, not by heat.  Tumor selectivity occurs through a combination of preferential retention of PHOTOFRIN® by the tumor and selective delivery of light to the tumor site.

A novel therapeutic technique, PHOTOFRIN® is FDA approved for the treatment of non-small cell lung cancer (NSCLC) and esophageal cancer. The product is available in the USA, several major European countries, Japan, several Latin American and Southeast Asian markets. Additional approved indications for PHOTOFRIN® include high-grade dysplasia (HGD) in Barrett's esophagus (BE) in North America and papillary bladder cancer in Canada and Argentina.

For additional information about PHOTOFRIN®, please see full prescribing information available at www.photofrin.com.

About Non-Small Cell Lung Cancer(2)

Lung cancer is the leading cause of cancer death in men and women. There are more than 200,000 patients with lung cancer each year. NSCLC is the most common type of lung cancer. It usually grows and spreads more slowly than small cell lung cancer.

There are several types of NSCLC including adenocarcinoma and squamous cell carcinoma. All can be treated with PDT at any stage.

About Esophageal Cancer(3)

Esophageal cancer (EC) forms in tissues lining the esophagus (the muscular tube through which f
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SOURCE Pinnacle Biologics, Inc.
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