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Treatment of First Patient in Phase I Clinical Trial of Bionomics' Anti-Cancer Drug BNC105
Date:2/25/2008

MELBOURNE, Australia, Feb. 26 /PRNewswire/ -- Bionomics Limited (ASX: BNO) today announced the initiation of treatment for the first patient in the Phase I trial of its anti-cancer drug, BNC105.

The BNC105 Phase I clinical trial involves treatment of patients with advanced cancer. Patients will be treated with BNC105 on days 1 and 8 of a 21 day cycle, over two cycles. The trial will be conducted at clinical sites within the Cancer Trials Australia network at the Royal Melbourne Hospital, the Peter MaCallum Cancer Centre and the Western Hospital in Melbourne.

Dr. Deborah Rathjen, CEO and Managing Director of Bionomics hailed the commencement of the Phase I trial as a significant milestone for the Company.

"We are excited to commence our trial of BNC105 and to announce our first patient has begun treatment," Dr Rathjen commented. "We will provide regular updates as we move through the trial, and I look forward to updating shareholders on our progress."

The primary objective for this trial is the evaluation of the safety and tolerability of BNC105. The results obtained from this trial will enable the identification of an appropriate dose of BNC105 for subsequent trials. Further objectives include, the evaluation of BNC105 pharmacokinetics and its activity against tumour vasculature and tumour growth.

BNC105 is a new type of anti-cancer drug called a Vascular Disruption Agent (VDA) which blocks the blood supply to a solid tumour, effectively "starving" the tumour of nutrients. Pre-clinical data indicates that BNC105 has a dual mechanism of action with the ability to not only block the supply of nutrients to the tumour but also to directly destroy cancer cells. In addition, BNC105 is retained in the tumour at high levels for an extended period of time, enhancing its' anti-cancer effect.

Although VDAs have strong potential for use in combination with traditional cancer treatment options, including chemotherapy, preclinical
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SOURCE Bionomics Limited
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