Navigation Links
Treatment Corrects Severe Insulin Imbalance in Animal Studies
Date:7/31/2008

--Could Become First Effective Drug for Rare Genetic Disorder in Children--

PHILADELPHIA, July 31 /PRNewswire-USNewswire/ -- Researchers have used a drug to achieve normal levels of blood sugar in animals genetically engineered to have abnormally high insulin levels. If this approach succeeds in humans, it could become an innovative medicine for children with congenital hyperinsulinism, a rare but potentially devastating genetic disease in which insulin levels become dangerously high.

"There is currently no effective medical treatment for children with the most common type of congenital hyperinsulinism," said study leader Diva D. De Leon, M.D., a pediatric endocrinologist at The Children's Hospital of Philadelphia. "This type of congenital hyperinsulinism is caused by mutations in genes that encode important potassium channels in the pancreatic beta cells." The study team, from Children's Hospital and the University of Pennsylvania School of Medicine, published their report online on July 17 in the Journal of Biological Chemistry.

In congenital hyperinsulinism (HI), genetic mutations damage the insulin-secreting beta cells in the pancreas. Insulin levels rage out of control and severely reduce blood glucose, a condition called hypoglycemia. If untreated, hypoglycemia may cause irreversible brain damage or death in children. Congenital HI occurs in an estimated one in 50,000 U.S. children, with a somewhat higher incidence among certain groups, such as Ashkenazic Jews.

For the past 20 years, the standard medical treatment for some forms of HI has been the drug diazoxide, which controls insulin secretion by opening up crucial potassium channels in beta cells. However, this drug does not work in the most common and severe forms of HI, in which mutations prevent those channels from forming.

When the abnormal beta cells are confined to a discrete portion of the pancreas, as occurs in approximately half of HI cases, precise surge
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Study Reveals Novel LCD Solution Provides Significant Benefits Versus Calcipotriol In Treatment Of Moderate Psoriasis
2. First Ever Study on Alzheimers Disease Treatment in Hispanics Presented at Major Medical Meeting
3. Four Alzheimers Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation
4. Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention
5. BioCryst Reports Positive Preliminary Results of a Shionogi & Co., Ltd. Sponsored Phase II Study of I.V. Peramivir for the Treatment of Influenza in the Outpatient Setting
6. Two New Alzheimers Disease Studies Show Advances Against Different Treatment Targets
7. Polyphenon Pharma Receives Orphan Drug Designation for Its Botanical Drug, Polyphenon E, for the Treatment of CLL
8. Journal of Clinical Oncology Article Highlights CellSearch(TM) Circulating Tumor Cell Test in Treatment of Metastatic Colorectal Cancer
9. MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis
10. InCode BioPharmaceutics, Inc. Announces Key Data Supporting New Treatment of Paroxysmal Nocturnal Hemoglobinuria (PNH)
11. Tibotec Conducts Two Pivotal Phase III Clinical Trials Studying TMC278 in Treatment-Naive Adults with HIV
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... Aug. 21, 2014 Asterias Biotherapeutics, Inc. (OTCBB: ... of regenerative medicine, announced today the appointments of Andrew ... newly expanded Board of Directors. With these additions, the ... of whom are independent. Andy Arno ... emerging growth companies. He is currently Managing Director of ...
(Date:8/20/2014)... Aug. 20, 2014  The National Association of ... results achieved by the real-time, pseudoephedrine (PSE) blocking ... Precursor Log Exchange (NPLEx), automatically blocks unlawful PSE ... meth offenders and make arrests. Data released by ... blocked the sale of more than ...
(Date:8/20/2014)... 20, 2014  The National Association of Drug ... achieved by the real-time, pseudoephedrine (PSE) blocking system ... Log Exchange (NPLEx), automatically blocks unlawful pseudoephedrine sales ... offenders and make arrests. Data released by NPLEx ... blocked the sale of more than 19,030 ...
Breaking Medicine Technology:Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 2Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 3Asterias Biotherapeutics Appoints Two Independent Directors and Announces Completion of Series A Common Stock Distribution 4Indiana's Stop-Sale System Achieves Significant Results In Battle Against Meth 2Missouri's Stop-Sale System Achieves Significant Results In Battle Against Meth 2
(Date:8/22/2014)... CA (PRWEB) August 22, 2014 AttorneyOne.com, ... regarding all the latest information from the FDA on ... , The US FDA announced on August 19, that ... Systems, model number DPB-125MICRO145 (Part number 7-10003), by Cardiovascular ... defective saline sheaths that could fracture during use and ...
(Date:8/22/2014)... Reacting to naysayers who are being skeptical about ... top PRP therapy LA specialist has firmly stated that ... with practical well researched science and nothing to do ... new medical breakthrough technology which focuses on healing and ... therapy. , The Managing Director of one of the ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Teen substance abuse ... Toledo, OH. The rising numbers of young adults falling victim ... staggering. To help make a difference in the community, the ... valuable resource for teens seeking to overcome their chemical dependency. ... find the best youth rehab center to focus on achieving ...
(Date:8/22/2014)... 2014 The rising numbers of teenage ... Over the years, countless lives have been lost due to ... in the community a new helpline was established to provide ... Northeast Ohio who are seeking to overcome their chemical dependency ... at (300) 400-2616, parents and their teens can speak immediately ...
(Date:8/22/2014)... Lexington, North Carolina (PRWEB) August 22, 2014 ... United Church Homes and Services (UCHS ), recently ... frail and at risk seniors with limited resources in ... open floor plan, fully operational kitchen, individually controlled heating ... The HUD Section 202 supportive housing community, consists of ...
Breaking Medicine News(10 mins):Health News:Diamondback 360 Peripheral Orbital Atherectomy System Recalled (Class I): AttorneyOne Monitors and Keeps Consumers Informed 2Health News:MetroMD With The Help Of PRP Therapy Helps People Fight Hip Injuries 2Health News:New Helpline Provides Hope for Troubled Teens in Toledo 2Health News:Troubled Teens in Akron, OH Can Receive Assistance from New Helpline for Addiction Recovery 2Health News:United Church Homes and Services Announce New Affordable Housing Community for Seniors 2
... Vall d,Hebron Hospital have diagnosed two patients affected with ... breathing due to irritating agents that are breathed in ... described two cases of patients with occupational vocal dysfunction. ... a closure in the vocal cords when inhaling. Under ...
... MINNEAPOLIS, Sept. 6 Two new issue briefs ... management,programs are evolving into employer partners to create ... ) "Corporate America Embraces New Culture ... of this emerging phenomenon:,a proactive vision for corporations ...
... NOT Vote for Merger; Says ,Shareholders Have Already ... at $5.60 per Share, NEW YORK, Sept. 6 Elliott ... (Nasdaq: BIVN ), today said the following letter has been ... Board of Directors Bioenvision, Inc. 345 Park Avenue, 41st ...
... Kris Carr is a photographer, director, producer and subject of ... Cancer." Carr is also the author of "Crazy Sexy Cancer Tips." ... and incurable cancer, but weeks later she ... treatment as her only option, Carr became determined to find ...
... Starting Drug Use with Painkillers Than Marijuana; Prescription ... Drug Abuse Remains a Concern, WASHINGTON, ... a five year low, according to the largest and,most comprehensive study of ... youth, nonmedical use of painkillers continues to be,an area of concern, with ...
... Sept. 6, 2007 CIGNA Group,Insurance today announced ... medical officer. Woolf will have responsibility for managing ... promote health and,wellness, absence management and productivity. ... clinical and business leaders,for CIGNA Group Insurance,s disability, ...
Cached Medicine News:Health News:Vocal cord dysfunction may be caused by work 2Health News:HealthFitness CEO Supports Move Toward Cultural Shift, and Science-Based Health Management Programming 2Health News:HealthFitness CEO Supports Move Toward Cultural Shift, and Science-Based Health Management Programming 3Health News:Elliott 'Extremely Dissatisfied' With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company 2Health News:Elliott 'Extremely Dissatisfied' With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company 3Health News:Elliott 'Extremely Dissatisfied' With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company 4Health News:Elliott 'Extremely Dissatisfied' With Genzyme Bid for Bioenvision; Believes Offer Significantly Undervalues Company 5Health News:Author Kris Carr to Sign 'Crazy Sexy Cancer Tips' at Two Borders(R) Stores in California 2Health News:Youth Drug Use at a Five Year Low, New Survey Shows 2Health News:Youth Drug Use at a Five Year Low, New Survey Shows 3Health News:Dr. Allen Woolf Appointed Chief Medical Officer For CIGNA Group Insurance 2
Standard Deflectable Catheters...
The Explorer ST "soft tip" catheter has a proximal shaft with a soft tip. It is available in both a 5F and 6F shaft configuration....
... offers a wide range of deflectable curve ... needs of children and other patients with ... demanding specifications using only the finest materials. ... wire braiding and extrusion technologies results in ...
A-Focus I & II Catheters. A-Focus steerable atrial mapping catheter. Available in 10, 12, 14 and 20 electrode configurations. (Shown with 14 electrodes)....
Medicine Products: