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Translational Science Expert, Dr. Melissa Ashlock, Joins aTyr Pharma to Advance Physiocrine-based Therapeutics
Date:5/18/2011

been overlooked. aTyr possesses a unique opportunity to treat grave diseases with innovative, high impact biologics. It is an honor to join such an outstanding scientific team to execute on their important mission."

Dr. Ashlock has recently served pharmaceutical companies and non-profit organizations to advance new drug discovery and development opportunities for unmet medical needs.  Since 1999, she has been involved with the Cystic Fibrosis Foundation (CFF), holding positions including vice president of drug discovery for its therapeutics affiliate, CFFT, and was part of the leadership team that helped transform cystic fibrosis (CF) venture philanthropy, a concept stemming from the visionary President and CEO Robert Beall, Ph.D. Dr. Ashlock also led the CFF's collaborative efforts to discover and develop drugs that addressed the basic defect in CF, including working with Vertex Pharmaceuticals on VX-770 and other approaches under investigation. Prior to CFF, she worked as a scientific investigator at the National Institutes of Health with Francis Collins, M.D., Ph.D., co-discoverer of the cystic fibrosis gene and Ron Crystal, M.D., a pioneer in gene therapy. She has been co-inventor or author of more than 50 issued patents and publications. She received her B.S. in biochemistry from Purdue University and her M.D. from Cornell University Medical College. She completed her medical residency at Dartmouth Medical School and is a licensed physician, board certified in adult internal medicine.

About Physiocrines

Physiocrines are derived from aminoacyl tRNA synthetases, which have been known for decades to function intracellularly in protein synthesis. Overlooked by genomic discovery efforts, Physiocrinesare extracellular proteins that modulate signaling pathways in a variety of physiological processes. These endogenous human proteins act through a variety of receptor classes via mechanisms distinct from current pharmaceuticals, a
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