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Transgenomic Signs Exclusive License for Cold-PCR Technology From the Dana-Farber Cancer Institute
Date:10/8/2009

d a technology that would permit us to screen patients earlier in their development of cancer and we hope that Cold-PCR provides us the sensitivity and analytical accuracy to achieve this goal. Discovering cancers at a much earlier phase of development will have a huge impact on cancer diagnosis and treatment."

"During our option period we tested the feasibility of Cold-PCR and developed practical laboratory improvements to the technology," said Dr. Eric Kaldjian, CSO at Transgenomic. "We demonstrated reproducible 30 - 50 fold enrichment of mutant cancer gene DNA, without needing any a-priori information on the position of the mutation. What this means is that one mutant DNA molecule in a hundred is effectively changed to one in two. As a result, we expect that Cold-PCR has significant applications with standard Sanger sequencing methods. Combining Cold-PCR with Transgenomic's WAVE DHPLC and Surveyor Nuclease products may have the potential to detect one mutant copy of DNA out of as many as a thousand normal copies and the sensitivity is likely to keep improving. This will be valuable in cancer-related mutation detection of free DNA in blood and body fluids and in producing a mutation profile of primary tumors to predict resistance to targeted therapies. It could also have application in analysis of mitochondrial DNA mutations, which can be present at very low levels."

"We are delighted to be able to develop jointly the application of Cold-PCR to Transgenomic's existing technologies" said Dr. Mike Makrigiorgos, Director of Medical Physics and Biophysics at Dana-Farber and an Associate Professor of Radiation Oncology at Harvard Medical School. "Together they promise a significant solution to high sensitivity detection of somatic mutations that are key to cancer biology."

Technical Information

When mutant and reference DNA samples from the same gene are mixed and re-annealed, variations between these seque
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SOURCE Transgenomic, Inc.
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