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Transgenomic Expands Distribution of SURVEYOR® Scan K-RAS Mutation Detection Kit With CE IVD Mark
Date:9/13/2010

tion which generates DNA fragments.  The different sized fragments of DNA present as individual peaks on a chromatogram when compared to wild type DNA.  

Numerous scientific studies report that K-RAS mutation status is a strong predictor of resistance to cancer treatment with epidermal growth factor receptor inhibitors. Determining the K-RAS mutation status  is especially important when determining treatment regimens for patients with colorectal cancer. Transgenomic's SURVEYOR Scan K-RAS Mutation Detection Kit CE IVD uses the established SURVEYOR Nuclease technology to identify mutations in the K-RAS gene that are associated with drug-resistant tumors.   Key features include:

  • Detects mutations by enzymatic cleavage at mutation sites due to mutant:wild-type heteroduplex formation
  • Identifies all known and unknown mutations in both K-RAS coding exons
  • Includes control templates for common mutation sites (codons 12, 13 and 61)
  • High analytic sensitivity — detects 1% of K-RAS mutant in a background of wild-type genomic DNA
  • Finds low level mutations frequently missed by sequencing
  • Simple interpretation — the SURVEYOR fragment analysis pattern can identify the position of mutation
  • Can be applied to paraffin-embedded tissues

SURVEYOR Scan K-RAS is the first of a series of kits for use in cancer mutation detection.  Transgenomic plans to follow it with kits for BRAF, PI-3 kinase, p53 and other key cancer genes in the near future.

About Transgenomic, Inc.  

Transgenomic, Inc. (www.transgenomic.com) is a global biotechnology company specializing in high sensitivity genetic variation and mutation analysis, providing products and services in DNA mutation detection and discovery for clinical research, clinical molecular diagnostics and pharmacogenomics ana
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SOURCE Transgenomic, Inc.
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