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Transgenomic Expands COLD-PCR License
Date:3/14/2011

s us to continue this effort. We have developed a variety of gene mutation assays now using COLD- and now Ice COLD-PCR and have obtained mutation detection levels that allow post-enrichment Sanger sequencing of somatic mutations which had initial concentrations in the sample of lower than 0.05% that of the wild type allele. This is in comparison to a typical detection level of 10% using Sanger sequencing alone. We are applying our enhanced technology to studying mutant DNA levels in plasma/serum and CTCs that correspond to the mutation found in tumors - thus demonstrating that this technique could serve as a screening or earlier detection method for finding these mutations in blood."

"Ice COLD-PCR is an important addition to our range of technologies as it is a key element in the development of improved levels of detection of mutations. By expanding our license to include additional sequencing methods, we are broadening the market opportunity for COLD-PCR under our exclusive license with the Dana-Farber Cancer Institute."

About Transgenomic, Inc.

Transgenomic, Inc. (www.transgenomic.com) is a global biotechnology company specializing in high sensitivity genetic variation and mutation analysis, providing products and services in DNA mutation detection and discovery for clinical research, clinical molecular diagnostics and pharmacogenomics analyses. Product offerings include the WAVE® Systems and associated consumables specifically designed for use in genetic variation detection and single- and double-strand DNA/RNA analysis and purification.  With broad applicability to genetic research, nearly 1,500 systems have been shipped to customers in more than 50 countries. The SURVEYOR® Mutation Detection Kits provide reagents and protocols for high sensitivity detection of mutations in DNA.  HANABI automated chromosome harvesting systems improve laboratory productivity with con
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