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Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines
Date:4/30/2008

OMAHA, Neb., April 30 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO), a global genetic analysis and services company, today announced the National Cancer Institute had approved a proposal to perform mutational analysis and sequencing of the mitochondrial genes in the NCI 60 cancer cell line panel.

Mitochondrial damage is increasingly recognized as an early warning signal in several different types of cancer. This is the first comprehensive evaluation of the mitochondrial genome in the NCI 60 panel. The data from this study will be a valuable tool for integrating mitochondrial genomics with other data derived from the NCI 60 panel.

"Tens of thousands of compounds have been tested against the NCI 60 cell lines in the NCI's pharmacological database of cancer drugs," chief scientific officer Dr. Eric Kaldjian described. "This collaboration makes it possible to test whether in vitro responses to anti-cancer agents are linked to alterations in the mitochondrial genome and can be detected with our sensitive mutation detection technology."

Chief executive officer Craig Tuttle remarked, "Over the last 2 years, we have grown our laboratory services business focusing on diseases associated with mitochondrial DNA. As we learn more about the mitochondria and its role in disease, we are finding that mitochondrial mutation testing can provide diagnostic insights earlier in the disease process giving physicians early warning signals they can use to monitor at risk patients or even begin therapy. This study is an important milestone for the company and will further validate our leadership in the analysis of the mitochondrial genome in disease. The NCI 60 panel study further demonstrates Transgenomic's expertise in the evolving area of diagnostic testing for mitochondrial mutations."

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Transgenomic is a global biotechnology company that provides unique products and services of automated high sensitiv
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