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Transgenomic, Inc. Expands SURVEYOR® Scan Product Line With BRAF and PIK3CA Mutation Detection Kits
Date:4/14/2011

ng track record in developing powerful mutation detection methods as our recent announcement on Ice COLD-PCR and BLOCker-Sequencing testifies," commented Craig Tuttle, Transgenomic's Chief Executive Officer. "We intend to transition our cutting edge research and development into commercial service laboratory assays as well as research-use-only and regulatory approved diagnostic kits. By combining our proprietary technologies and leveraging their unique properties for high sensitivity mutation detection, Transgenomic will advance its leading position in high sensitivity genetic analysis. Our newly developed SURVEYOR Scan BRAF and PIK3CA kits will further strengthen our portfolio."

About the SURVEYOR Nuclease and WAVE® HS DHPLC Platform

SURVEYOR Scan technology is a patented method for mutation detection that uses a PCR amplification reaction and hybridization to form mis-paired DNA molecules between normal and mutant sequences which are then cleaved using SURVEYOR Nuclease and detected on a chromatogram. Key features of the SURVEYOR Scan Kits include: (1) Detection of all known and unknown mutations in the amplicon of interest; (2) Inclusion of control templates for common mutation sites; (3) High analytic sensitivity, enabling the detection of a 1% mutant population in a background of wild-type genomic DNA, which would typically be missed by sequencing and other techniques; (4) Simple interpretation — the SURVEYOR fragment analysis pattern can aid in identifying the position of the mutation without the additional cost of full sequencing; (5) Convenient parallel processing facilitated by a single set of PCR conditions and analysis protocols for all kits; and (6) Successful application to DNA extracted from formalin-fixed paraffin-embedded tissues.

About Transgenomic, Inc.

Transgenomic, Inc. (www.transgenomic.com) is a
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