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Transgenomic, Inc. Executes License Option agreement for Parkinson's Disease Diagnostic Markers with Gene Solutions, LLC
Date:12/17/2009

OMAHA, Neb., Dec. 17 /PRNewswire-FirstCall/ -- Transgenomic, Inc. (OTC Bulletin Board: TBIO) announced today that it has reached agreement with Gene Solutions for an exclusive licensing option to a set of validated mutations found in Parkinson's disease patients that can form the basis of a novel and accurate diagnostic test for Parkinson's disease. Transgenomic's platform mitochondrial mutation detection technology will be evaluated and optimized to develop a diagnostic test that evaluates and quantitates the presence of low-level mitochondrial DNA (mtDNA) variants. These mutations have been demonstrated to be present in Parkinson's disease patients but rarely in age-matched control individuals.

Parkinson's disease is a devastating neurological disorder affecting at least 1 million diagnosed patients and potentially another 3-4 million undiagnosed patients in the US alone. Symptoms can be modified to some degree by early intervention and treatment with dopamine or other neurological enhancing agents. The earlier the diagnosis, the better the long-term outcome can be for the sufferers of this disease. But often the disease has progressed significantly before a diagnosis can be accurately made and treatment initiated.

Each cell in the body has hundreds to thousands of mitochondria, organelles that produce the energy required for cells to function normally. Mitochondria contain their own genome that encodes many of the proteins necessary to perform cellular energy production. Damaged or mutated mitochondrial DNA (mtDNA) leads to cellular metabolism disorders by interfering with energy production. A large body of research conducted over the past twenty years has implicated mitochondrial abnormalities in certain neurodegenerative diseases including Parkinson's disease. Gene Solutions has discovered a specific region of mtDNA in which variants in the genetic sequence are present in Parkinson's patients. These variants are prese
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SOURCE Transgenomic, Inc.
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