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Transdermal Drug Delivery - Technologies, Markets, and Companies
Date:1/3/2012

Microneedle and needleless technologies are also described. Transdermal technologies may be applied for several categories of pharmaceuticals used for the treatment of disorders of the skin or for systemic effect to treat diseases of other organs. Several transdermal products and applications include hormone replacement therapy, contraception, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. The market for transdermal drug delivery is analyzed according to technologies and therapeutic areas from 2011 to 2021. This market is analyzed according to geographical regions as well.

Table of Contents

0. Executive Summary 11

1. Basics of Transdermal Drug Delivery 13

Introduction 13

Historical landmarks in transdermal drug delivery 13

Anatomy and physiology of skin 14

Transcutaneous absorption 14

Transdermal versus other methods of drug delivery 14

Advantages of transdermal drug delivery 15

First-Pass Effect 15

Drawbacks of transdermal delivery 15

Factors that influence transdermal drug delivery 15

Events governing transcutaneous absorption 16

Properties of the skin 16

Properties of drugs 17

The role of pH and pharmacokinetics 17

Intradermal disposition of drugs after topical application 18

2. Transdermal Drug Delivery Technologies 19

Introduction 19

Local application formulations 20

Crystalline topical formulations 20

Microemulsions for transdermal drug delivery 20

Nanoemulsions for transdermal drug delivery 21

Transdermal gel technology 21

Film forming polymeric solutions 22

Biphasix system 23

Penetration enhancers 23

Chemical enhancers 23

Nitric oxide-based transdermal drug delivery 25

Vesicular transdermal carriers 25

Liposomes 26

Transfersomes 26

Ethosomes 27

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