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Trana Discovery and Southern Research Institute Find Bioactive HIV Antiviral Compounds
Date:10/28/2009

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"These data indicate that the TRANA Discovery assay has identified a number of compounds with modest antiviral activity against HIV-1," said Roger Ptak, Co-Principal Investigator, Southern Research Institute, in his report to the Division of Acquired Immunodeficiency Syndrome (DAIDS) within NIAID. "Additional testing of compounds with similar structures, as well as broader HTS, should lead to the identification of lead compounds that inhibit HIV-1 replication through the novel mechanism of inhibiting the interaction between tRNALys3 and viral genomic RNA."

As a result of this successful pilot study, DAIDS has approved $700,000 of additional funding for the contract with Southern Research Institute in order to screen an additional 300,000 compounds and to conduct confirmatory testing of selected lead compounds. Lead candidates (or analogs) identified through this screening will be pursued by Trana Discovery for development and to secure the property rights and patents as deemed appropriate.

Toward that end, Trana Discovery is seeking organizations interested in licensing identified leads or that hold diverse collections of compounds or compounds with known bioactivity against HIV but unknown mechanism of action to identify candidates for drug development.

The use of high-throughput screening (HTS) assays developed by Trana Discovery can provide licensing opportunities for exclusive rights to new drug classes and reduce the cost and time for drug discovery.

"We are excited about the results from the initial screening efforts and for the confidence exhibited by the NIAID/DAIDS by this additional funding commitment," said Steve Peterson, CEO of Trana Discovery. "We remain very optimistic that the use of our HIV assay will lead to new antivirals for the treatment of this disease."

NIAID conducts and supports research to stu
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SOURCE Southern Research Institute
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