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Tosedostat OPAL Study in Acute Myeloid Leukemia Published in Lancet Oncology
Date:3/4/2013

ww.celltherapeutics.com/">www.CellTherapeutics.com.

About Chroma Therapeutics

Chroma Therapeutics Limited, based in Oxford (UK), is a drug development company focused in the fields of oncology and inflammatory disorders. Chroma is building a broad pipeline of first- or best-in-class treatments utilising its expertise in chromatin biology and its novel intracellular accumulation technologies, which include the ability to selectively target drugs to macrophages. Chroma is backed by a number of leading specialist investors, including Abingworth, Essex Woodlands, Gilde, Phase4 and The Wellcome Trust. More information about Chroma can be found at www.chromatherapeutics.com.

References:

1. American Cancer Society, Cancer Facts & Figures 2012. Available at http://tinyurl.com/8kylgc7. Accessed February 2013.
2. The Leukemia and Lymphoma Society, Acute Myeloid Leukemia, Rev. 2011. Available at http://tinyurl.com/d72ycja. Accessed February 2013.

This press release includes forward-looking statements that involve a number of risks and uncertainties, the outcome of which could materially and/or adversely affect actual future results and the trading price of CTI's securities. Specifically, the risks and uncertainties that could affect the development of tosedostat include risks associated with preclinical and clinical developments in the biopharmaceutical industry in general and with tosedostat in particular including, without limitation, the potential failure of tosedostat to prove safe and effective for the treatment of AML, MDS, multiple myeloma, blood related cancers and solid tumors as determined by the U.S. Food and Drug Administration and/or the European Medicines Agency; that tosedostat may not be more effective when used in combination with azacytidine; that CTI cannot predict or guarantee the
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