Navigation Links
Tosedostat OPAL Study in Acute Myeloid Leukemia Published in Lancet Oncology
Date:3/4/2013

  • Overall response rate (ORR) of 22% (16/73), with 10% (7/73) achieving a complete response (CR) and 29% (21/73) of patients achieving stable disease (SD) for a disease control rate of 51%.
  • High response rates were observed in patients who previously received HMAs or initially were diagnosed with MDS, with an ORR of 38% (10/26) and 37% (7/19), respectively.
  • Median overall survival (OS) for patients achieving a CR was 322 days; partial response (PR) 195 days; and SD 162 days.
  • Adverse events were similar between dosing groups. Tosedostat was generally well-tolerated, with the majority of adverse events of grade 1 and 2. The most common treatment-related serious adverse event was febrile neutropenia reported in 29% of patients. 

"There are limited therapeutic options available for elderly patients who, after failing hypomethylating therapy, experience AML progression from MDS," said Dr. Cortes. "The novel mechanism of action and observed response rate in this completed Phase 2 study suggests that tosedostat could address this unmet medical need. We are currently conducting a Phase 2 study investigating the combination of tosedostat with azacytidine - an HMA, or low-dose cytarabine, a standard leukemia therapy in patients with relapsed or refractory AML and MDS - to determine if tosedostat would be safe and more effective when used in combination with these agents." 

The publication by Dr. Cortes, et al. titled "Two dosing regimens of tosedostat in elderly patients with relapsed or refractory acute myeloid leukemia (OPAL): a randomized open-label phase 2 study," is available at http://www.thelancet.com/journals/lanonc/issue/current.

About Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS)

About 13,780 new cases of AML were expected to be diagnosed in the Un
'/>"/>

SOURCE Cell Therapeutics, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Longitudinal Study Highlights Evolving Role of Medical Science Liaisons with Thought Leaders and Product Development
2. New Study Shows Cannabis Effects on Driving Skills
3. Independent Study Published in Clinical Infectious Diseases Highlights the Importance of Antimicrobial Removal Systems in Blood Culture to Rapidly and Accurately Aid in the Diagnosis of Sepsis
4. University Hospitals Case Medical Center Presents Study On The Elimination Of Retained Surgical Sponges
5. MD+DI, the Global MedTech Authority, Publishes One-of-a-Kind Study with ITG Market Research on the Medical Device Outsourcing Landscape
6. New Direct-to-Consumer Prescription Delivery Channel Mitigates Risk of Medication Non-Adherence Highlighted in JAMA Internal Medicine Study
7. KaloBios Presents Clinical Results with Anti-GM-CSF Antibody in Persistent Asthma Data from KB002 Phase 1/2 Study Presented at the American Academy of Allergy, Asthma and Immunology Meeting
8. Study Shows Medicare Savings When Local Pharmacies Fill 90-Day Prescriptions
9. Isis Pharmaceuticals Initiates Phase 2 Study Of ISIS-CRP Rx In Patients With Atrial Fibrillation
10. Adynxx Enrolls First Patient in Phase 2 Proof-of-Concept Study for AYX1, Lead Compound for the Prevention of Post-Surgical Pain
11. First U.S. Patients Treated in PneumRx RENEW Pivotal Study for Treatment of Severe Emphysema
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... N.J. , Sept. 1, 2015 Konica ... CS-7s Computed Radiography (CR) system, designed to deliver enterprise ... By utilizing the same Control Station as the Konica ... assured with an upgrade path from CR to DR. ... imaging to help improve workflow with unparalleled reliability and ...
(Date:9/1/2015)... UT Southwestern Medical Center President Dr. ... U.S. Representatives Michael C. Burgess , M.D., and ... the 21 st Century Cures Act, bipartisan legislation ... the United States Senate. ... Sciences members, department chairs, center directors, and leading researchers ...
(Date:9/1/2015)... 2015   Alpha Imaging LLC , a leading distributor of ... announced today that they have been awarded exclusive rights to represent ... Michigan.   The new territory supplements Alpha Imaging,s existing Shimadzu sales and ... Ohio , Indiana , Pennsylvania ... , West Virginia , Delaware ...
Breaking Medicine Technology:Konica Minolta Launches New CR System with Low-Cost Upgrade Path to DR 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 2U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 3U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 4U.S. Rep. Michael C. Burgess, M.D., hosts roundtable at UT Southwestern to discuss pivotal 21st Century Cures Act and future of biomedical science 5Alpha Imaging Expands Shimadzu Territory 2
... 21, 2011 /PRNewswire-Asia-FirstCall/ -- Tongjitang Chinese Medicines Company (the ... leading specialty pharmaceutical company focusing on the development, manufacturing, ... China, today announced that it plans to release its ... the market close on March 25, 2011. ...
... today announced that its Board of Directors has appointed Dirk ... immediately.  Mr. Allison has been the interim CEO of the ... about joining CCS Medical as its President and Chief Executive ... markets and I look forward to continuing our growth in ...
Cached Medicine Technology:Tongjitang Chinese Medicines Company to Announce Fourth Quarter and Full Year 2010 Financial Results 2
(Date:9/1/2015)... ... September 01, 2015 , ... OncLive® today announced ... News & World Report, to provide breaking news and information about the hospital’s ... within OncLive, which provides oncologists resources and information?they need to deliver the best ...
(Date:9/1/2015)... ... 2015 , ... PetPace, the provider of an innovative IoT ... today announced its integration with leading veterinary Practice Management Software vendor Cornerstone. ... Management Software packages in the US. Practice Management Software helps veterinarians manage every ...
(Date:9/1/2015)... ... September 01, 2015 , ... ... release of version 5.2 of the FirstSpirit Content Management System with new capabilities ... the new version of FirstSpirit, companies will be well on their way to ...
(Date:9/1/2015)... ... September 01, 2015 , ... WorkCare, Inc., a national ... medical management team as an Associate Medical Director. , WorkCare specializes in ... the U.S. and abroad. , Dr. Nelson has a diverse background. He ...
(Date:9/1/2015)... CA (PRWEB) , ... September 01, 2015 , ... Agriculture ... just a few of the topics to be discussed at Seedstock’s 4th Annual Sustainable ... 3-4, 2015, at UC San Diego. , In addition to keynotes Pierre Sleiman, ...
Breaking Medicine News(10 mins):Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 2Health News:OncLive® and Cleveland Clinic Team up to Provide News, Information About Cancer Research and Patient Care 3Health News:Petpace-Cornerstone Integration Lowers Overhead, Raises Data Visibility for Veterinary Practices 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 2Health News:Dr. Brent Nelson Joins WorkCare, Inc., as Associate Medical Director 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 2Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 3Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 4Health News:Experts in Urban and Local Food Systems Development to Address Seedstock Sustainable Agriculture Conference Nov. 3-4 Discounted ticket sales end Sept. 4 5
... People find safety in those who think the same way, ... -- Whatever you believe, new research suggests that you,re likely ... whether they be friends or talking heads on television. , ... very safe way of protecting your beliefs. It,s a little ...
... eCardio Diagnostics , one of the ... it has received a significant minority investment from Sequoia Capital. ... company was founded in 2004. , , "The ... of eCardio," noted Larry Lawson, President and Chief Executive Officer. ...
... the Bed Management Suite powered by TeleTracking XT(TM) , , ... Flow 2.0", its next generation of patient flow applications, with ... powered by Tele Tracking XT (TM). , ... on the Tele Tracking XT (TM) platform since 2007 ...
... Health Services, Inc. (Nasdaq: GTIV ), a leading ... has purchased the assets of a homecare operation from the ... of Health in West Virginia. , , Originally established ... to serve the growing need for homecare in Nicholas County, ...
... Inc. (Nasdaq: ALGN ), the inventor of Invisalign(R), ... financial results on Thursday, July 23, 2009 after the close ... and First Call and will be available on the Investor ... , , Following the press release, the Company will ...
... RealMed, a leader in web-based revenue cycle management solutions ... launch of its new website. The new website gives ... RealMed provides basic and detailed information about its real-time ... their individual features and benefits. The site offers the ...
Cached Medicine News:Health News:Your Surroundings Mirror Your Beliefs 2Health News:Your Surroundings Mirror Your Beliefs 3Health News:eCardio Receives Significant Investment in Private Funding from Sequoia Capital 2Health News:Industry Leader Announces Next Generation of Patient Flow Automation 2Health News:Industry Leader Announces Next Generation of Patient Flow Automation 3Health News:Gentiva(R) Health Services Acquisition Extends Certificate-of-Need Coverage in West Virginia 2Health News:Gentiva(R) Health Services Acquisition Extends Certificate-of-Need Coverage in West Virginia 3Health News:Align Technology to Announce Second Quarter Fiscal 2009 Results on July 23, 2009 2
Enzyme immunoassay for the quantitative determination of IgG autoantibodies against type IV collagen of glomerular or alveolar basement membrane (GBM) in serum and plasma....
... immunosorbent assay method for the semi-quantitative ... GBM in human serum. The results ... as an aid in the diagnosis ... of anti-GBM antibodies including Goodpastures Syndrome. ...
... intimately involved in the control of the ... tissues, which synthesize and secrete male and ... circulating FSH is controlled by these sex ... FSH Quantitative Test Kit is based ...
... Class II Direct to High Res SSP kits provide ... single tray. Locus specific typing on a single tray ... Straight from genomic DNA to high resolution results, ... level typing with a single tray , Unique reaction ...
Medicine Products: