Navigation Links
TorreyPines Therapeutics Initiates Clinical Trial to Evaluate Analgesic Effect of Oral Prodrug of Tezampanel
Date:6/4/2008

LA JOLLA, Calif., June 4 /PRNewswire-FirstCall/ -- TorreyPines Therapeutics, Inc. (Nasdaq: TPTX) today announced it has initiated a clinical trial to evaluate the analgesic effect of NGX426, the oral prodrug of its lead product candidate, tezampanel.

The randomized, double-blind, placebo-controlled Phase I trial will enroll 18 healthy volunteers at a single center in the United States. The trial is designed to evaluate the compound's safety and tolerability and to assess the time of onset, magnitude and duration of its analgesic effect. Specifically, the study will evaluate the effect of NGX426 on hyperalgesia, an abnormally increased pain state, and allodynia, pain resulting from normally non-painful stimuli to the skin, induced by intradermal injections of capsaicin. The primary endpoint is subject self-report of spontaneous pain following the injection of capsaicin.

"We believe there is a substantial commercial opportunity for NGX426 as a novel, oral analgesic," said Neil Kurtz, M.D., President and Chief Executive Officer of TorreyPines Therapeutics. "Data we have obtained in our ongoing Phase I maximum tolerated dose study demonstrate that the drug is well-tolerated at single doses up to and including 210 mg and that NGX426 is rapidly converted to tezampanel. Moreover, this capsaicin study, if successful, will enable us to further take advantage of the versatility of NGX426 and the overall tezampanel franchise."

Subjects in the trial, which involves the recognized and validated capsaicin-induced pain model, will receive single doses of 90 mg and 150 mg of NGX426 versus placebo in a three-way crossover design.

Tezampanel is the first AMPA/kainate-type glutamate receptor antagonist to be studied in clinical t
'/>"/>

SOURCE TorreyPines Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds
2. Multiple Dose Clinical Trial of TorreyPines Therapeutics Tezampanel Demonstrates Compound is Safe and Well-Tolerated
3. Pharmacokinetic Data Suggest NGX426, TorreyPines Therapeutics Oral Prodrug of Tezampanel, May be Effective in Treating Acute Migraine Headache
4. Tezampanel, TorreyPines Therapeutics Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego
5. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
6. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
7. TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
8. BN ImmunoTherapeutics Starts Clinical Trials With Prostate Cancer Vaccine
9. Amicus Therapeutics Begins Phase 2 Clinical Trial of AT2220 in Pompe Disease
10. Access Pharmaceuticals Presents New Data on the Companys Cobalamin(TM) Technology at an International Polymer Therapeutics Symposium
11. Cell Therapeutics, Inc. (CTI) Announces Presentations at American Society of Clinical Oncology (ASCO) Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)...  Medical Science Liaisons play a large role in ... medical device industry and key stakeholders, the role of ... as the device industry relies on them to build ... benchmarking firm, Best Practices, LLC, one area where Medical ... by harnessing new technology to enable education. Online conferences ...
(Date:12/22/2014)... , Dec. 22, 2014 Apnea Sciences ... corporate offices in Aliso Viejo , ... due to the tremendous growth and worldwide expansion, a ... of patented SnoreRx, the anti snore cure have exceeded ... said, "We are now in 23 countries and ...
(Date:12/22/2014)... 2014 Research and Markets ( ... "Investment Analysis of the US Medical Device ... http://photos.prnewswire.com/prnh/20130307/600769 ... device sector identifies the key trends and rationale ... and mergers and acquisitions. The study ...
Breaking Medicine Technology:Role of Medical Science Liaisons Evolving in Medical Device Sector 2Investment Analysis of the US Medical Device Sector 2
... Matrixx Initiatives, Inc. (Nasdaq: MTXX ), an over-the-counter healthcare company, announced today ... March 31, 2010 , will be released after the market closes on ... following morning on Tuesday, May 11, 2010 at 11:00 AM ... To access the teleconference, ...
... that a new market research report is available in its catalogue: , ... Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence ... http://www.reportlinker.com/p0191948/Stakeholder-Opinions-Cardiovascular-and-Metabolic-Generics----Generics-continue-to-gain-prominence.html , ... , , , ...
Cached Medicine Technology:Matrixx Initiatives, Inc. Sets Time for Discussion of Fourth Quarter and Fiscal 2010 Financial Results 2Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 2Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 3Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 4Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 5Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 6Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 7Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 8Reportlinker Adds Stakeholder Opinions: Cardiovascular and Metabolic Generics - Generics continue to gain prominence 9
(Date:12/25/2014)... December 26, 2014 Recently, Dylan Queen, ... has excitedly released its collection of discounted prom dresses, ... Percy, a senior spokesman of the company, the promotion ... this promotion is to expand the UK market. , ... several different colors, lengths, and styles: A-line strapless, empire ...
(Date:12/25/2014)... Woodland Hills, California (PRWEB) December 25, 2014 ... in her home in Woodland Hills, California after an ... Harris passed away on Christmas Eve evening in her ... battle with aggressive metastatic breast cancer. ... International for over forty years, she pioneered and championed ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- The risk of ... holidays, so you need to be extra cautious, an ... we see a significant increase in patients coming in ... the Suffolk County Volunteer Firefighters Burn Center of Stony ... should be full of joy, but if not careful, ...
(Date:12/25/2014)... December 25, 2014 AngelWeddingDress.com tries its ... the online realm. Today, the business has introduced its ... site-wide prom dress promotion. , The new prom outfits ... and every dress lover. They are specially designed for ... prom dresses should visit its website before Jan. ...
(Date:12/25/2014)... (PRWEB) December 25, 2014 Residents ... Retirement Community, recently showed their generous spirit by ... the Catawba County Parenting Network- Grandparents Raising Grandchildren ... children gathered around the largest Christmas tree on ... presents purchased by residents of the Abernethy Village ...
Breaking Medicine News(10 mins):Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4Health News:Don't Let Burns Mar Your Holidays 2Health News:Angelweddingdress 2015 Prom Dresses Online Now 2Health News:Retirement Community Residents Make Impact During Holiday Season 2
... Joins Canary,s Board of Directors, SAN JOSE, ... leading regional home improvement retailer, today announced a,partnership ... solely to the funding, discovery and development of,tests ... & CEO,of OSH has been appointed to Canary ...
... more likely to suffer dangerous spike in blood flow ... News) -- Researchers have identified a gene variation in ... physical effects of mental stress that it causes a ... condition called ischemia. , Patients with this particular variation ...
... than before, report shows , , TUESDAY, April 22 (HealthDay ... not rising steadily and uniformly across the United States. ... and 1999, death rates for women went up in ... in life expectancy have worsened across the country. , ...
... An Oregon Health & Science University Cancer Institute ... indicator of survival for men with advanced prostate cancer. ... special type of protein produced by the liver that ... mean that a simple blood test that is already ...
... Robert Wood Johnson Foundations Physician Faculty Scholars program has ... assistant professor of pediatrics at UT Southwestern Medical Center. ... the relationship between infant feeding practices and iron deficiency ... a small group of junior faculty nationwide selected to ...
... prostate cancer more than halved in the Tyrol after a ... the disease, according to research published in April issue of ... 87 per cent of eligible men have been tested at ... 2005 cancer deaths had fallen by 54 per cent, compared ...
Cached Medicine News:Health News:Orchard Supply Hardware Partners With Canary Foundation 2Health News:Orchard Supply Hardware Partners With Canary Foundation 3Health News:Gene Variant Boosts Risk for Stress-Related Ischemia 2Health News:Disparities in Life Expectancy Increasing 2Health News:Disparities in Life Expectancy Increasing 3Health News:OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival 2Health News:UT Southwestern Medical Center receives grant from the Robert Wood Johnson Foundation 2Health News:Prostate cancer screening program leads to bigger fall in death rates than surrounding areas 2Health News:Prostate cancer screening program leads to bigger fall in death rates than surrounding areas 3
... Pediatric Sarmiento-style PTB tibial orthosis ... Lined with closed-cell foam at bony ... Selection of 3 modular footpiece/shoe insert ... patient. Stretch Velcro® design fits especially ...
... Our "Stock Saver" hip abduction orthosis provides the ... Hip with one major difference. Our design innovation ... easily adapted for use in either left or ... lefts and rights. A comfortable neoprene padding is ...
... Brace was developed in collaboration with Dr. ... Disorders at the University of Pittsburgh. The ... abduction and adduction in 15 increments from ... lock in any position from -30 to ...
... Harness™ A Pavlik-type harness with greatly ... treatment of congenital hip dysplasia. Color-coded ... and antislip foot pieces.,Color-coded anterior straps ... can be made while the child ...
Medicine Products: