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TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds
Date:2/14/2008

e the company's first for tezampanel in a

non-pain indication and is intended to demonstrate the potential

utility of tezampanel for indications beyond migraine and chronic

pain.

-- Complete the ongoing Phase I maximum tolerated dose trial of

NGX426, the oral prodrug of tezampanel, in the first half of the

year.

-- Initiate a Phase I single-dose trial of NGX426 in a capsaicin model

for neuropathic pain in the first half of the year. The purpose of

this trial is to show that tezampanel may be an effective analgesic

when administered orally as NGX426. Tezampanel has been shown in

six Phase II trials to be an effective analgesic when administered

parentally.

-- Initiate a Phase I multiple dose trial of NGX426 in the second half

of the year.

Muscarinic agonist

-- Initiate a Phase II trial of NGX267 in xerostomia, or dry mouth,

secondary to Sjogren's syndrome in the first half of the year. The

company has demonstrated the safety of single and multiple doses of

NGX267 in three Phase I trials involving healthy volunteers. In two

of these studies, statistically significant increases in salivary

flow were demonstrated.

Expand Business Development Initiatives Across Pipeline

The company will evaluate partnership opportunities for tezampanel and NGX426 as treatments for migraine headache and other chronic pain and non-pain indications. This will be in addition to the company's current partnering activities involving its gamma-secretase modulator (GSM) program, phenserine, Posiphen(TM) and bisnorcymserine.

Streamline Operations

With the more focused development and discovery activities and the February 28, 2008, conclusion of the discovery-phase GSM collaboration with Eisai Co., Ltd., the compan
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SOURCE TorreyPines Therapeutics, Inc.
Copyright©2008 PR Newswire.
All rights reserved

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Related medicine technology :

1. Multiple Dose Clinical Trial of TorreyPines Therapeutics Tezampanel Demonstrates Compound is Safe and Well-Tolerated
2. Pharmacokinetic Data Suggest NGX426, TorreyPines Therapeutics Oral Prodrug of Tezampanel, May be Effective in Treating Acute Migraine Headache
3. Tezampanel, TorreyPines Therapeutics Lead Compound, Reduced Muscle Spasticity and Rigidity in Preclinical Study Conducted at University of California, San Diego
4. TorreyPines Therapeutics Completes Phase I Multiple Dose Clinical Trial of NGX267, a Selective M1 Agonist for the Potential Treatment of Cognitive Impairment Associated with Schizophrenia
5. TorreyPines Therapeutics Initiates a Phase I Multiple Dose Clinical Trial of Tezampanel
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