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Topaz Pharmaceuticals Names Bob Radie Chief Executive Officer
Date:11/17/2010

where he led several different sales forces and played a key role in numerous product launches.  Among the flagship products he successfully launched were Prozac®, Zyprexa® and Actos®.  Mr. Radie holds a Bachelor of Science degree in chemistry from Boston College.

"I am honored to join the team at Topaz as we advance a promising late-stage development product targeted for the treatment of head lice, a common condition that affects millions of children.  There is a true need for effective, safe and convenient treatment options for eradication of head lice," said Radie.  "Ivermectin has a long history of productive use for the treatment of other parasitic infections.  Studies conducted to date in this development program have shown very promising results.  I look forward to partnering with the team and Board of Directors as we propel Topaz to the next phase of commercial growth and optimizing the value of the asset."

About Ivermectin

Ivermectin is a broad-spectrum antiparasitic agent.  Its known mechanism of action is that it binds selectively to certain ion channels present in invertebrate nerve and muscle cells but not present in mammals. The resulting increase in permeability of the cell membrane causes the death of certain parasites.  First developed from a soil bacterium, widespread oral use of ivermectin, under the brand name Mectizan®, began in 1987 in sub-Saharan Africa to control onchocerciasis (river blindness) in humans.  As of 2009, over 800 million doses of oral ivermectin had been administered as part of a river blindness eradication program.(1)  A novel topical form of ivermectin is currently under clinical investigation at Topaz as a potential therapy to treat head lice. 

About Topaz Pharmaceuticals

Topaz Pharmaceuticals Inc. is a privately held specialty pharmaceutical company developing innovative treatments for the adult and
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SOURCE Topaz Pharmaceuticals Inc.
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