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Topaz Pharmaceuticals Announces Positive Data from Topical Ivermectin Trials Presented at Society of Pediatric Dermatology
Date:7/28/2010

rough missed school days and caregiver time off work.  Children found to be infested with head lice may not be allowed to return to school due to local no-nit policies.(7) Despite parents' best efforts to get rid of lice, current treatments are often ineffective, and safety and convenience issues have been associated with the available prescription treatments.

About Ivermectin

Ivermectin is a broad-spectrum antiparasitic agent that binds selectively to certain ion channels in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane, resulting in paralysis and death of the parasite. First developed from a soil bacterium isolated in 1974, widespread oral use of ivermectin began in 1987 in sub-Saharan Africa to control onchocerciasis (river blindness) in humans.  As of 2007, over 530 million doses of oral ivermectin, under the brand name Mectizan (registered trademark of Merck & Co.), had been administered as part of a river blindness eradication program.(8)  A novel topical form of ivermectin is currently under clinical investigation at Topaz as a potential therapy to treat head lice. 

About Topaz Pharmaceuticals

Topaz Pharmaceuticals Inc. is a privately held biotechnology company developing innovative treatments for the adult and pediatric markets. The company's lead product is a topic cream formulation of ivermectin, a broad spectrum parasiticide, under development for the treatment of head lice. The company is currently conducting two Phase 3 studies of ivermectin, both of which are expected to conclude in 2010. For more information about Topaz Pharmaceuticals Inc. please visit '/>"/>

SOURCE Topaz Pharmaceuticals
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