Navigation Links
Tolerx Presents Preclinical Data on Novel T-cell Modulator, TRX518, for Antitumor Immune Response at Federation of Clinical Immunology Societies Scientific Meeting
Date:6/25/2010

encouraged by the preclinical results with anti-GITR immunotherapy. This approach appears to induce unique mechanisms for augmenting antitumor immune responses and holds promise for treating malignancies in man," said Louis Vaickus, MD, Chief Medical Officer at Tolerx. "In a murine model of established colon cancer, the results, especially the complete remissions, were striking and these findings represent preclinical proof of concept for TRX518."

About TRX518

TRX518 is a targeted T-cell immunomodulator that binds to the glucocorticoid-induced tumor necrosis factor receptor (GITR) found on multiple types of T cells and other immune cells. Activated GITR plays a role in directing the antitumor immune response via activating tumor-antigen-specific T effector cells, as well as abrogating the suppression induced by inappropriately activated T regulatory cells. In preclinical studies, TRX518 achieved its targeted effect without compromising normal immune function and preclinical models suggest TRX518 may have a reduced risk of causing the serious inflammatory side effects that can result from cytokine release.

About Tolerx

Tolerx, Inc., a world leader in the understanding of T cell function, is developing novel therapies intended to treat autoimmune diseases, diabetes, and cancer by specifically modulating T cell activity. The company's pipeline includes its lead candidate, otelixizumab, a targeted T cell immunomodulator in Phase 3 development for the treatment of type 1 diabetes that is partnered with GlaxoSmithKline. TRX1, a Phase 1 candidate, is a nonlytic anti-CD4 antibody that is being developed for the treatment of aberrant or untoward immune responses. The company also has three preclinical candidates, TRX518, TRX585, and TRX385, which enhance immune responses and as such are being evaluated
'/>"/>

SOURCE Tolerx, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association
2. Tolerx Initiates Dosing of Otelixizumab, a Novel Type 1 Diabetes Agent, in DEFEND, a Phase 3 Clinical Trial
3. Tolerx Announces Achievement of Milestones upon anti-CD4 Antibody Program Advancement and Initiation of Phase 1 Clinical Trial
4. Tolerx Advancing Novel Type 1 Diabetes Agent into Phase III Clinical Trial Program Following End of Phase II FDA Meeting
5. Tolerx Achieves Milestone with Completion of Phase Ib Clinical Study of TRX1 in Cutaneous Lupus Erythematosus
6. Lexicon Presents Data Describing LX4211 Positive Phase 2 Clinical Results and Novel Mechanism of Action for Type 2 Diabetes
7. Onyx Pharmaceuticals Presents Interim Results of Phase 1b Carfilzomib Combination Trial
8. Lilly Presents New Data in Advanced Melanoma - A Difficult-To-Treat Cancer That Causes Majority of Skin Cancer Deaths
9. Mpex Pharmaceuticals Presents Positive Phase 2 Clinical Trial Results of Aeroquin(TM) (MP-376) Treatment in Cystic Fibrosis Patients
10. Spectros Presents at the Pediatric Academic Societies (PAS) National Conference 2010
11. Lexicon Presents Positive Outcome in IBS Patients Treated With LX1031 and Data Supporting Mechanism of Action
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... -- Research and Markets has announced ... (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, Microwave) Market - ... On the basis of type ... been divided into eight major segments, namely, light/laser, ... ablation technologies. The light/laser ablation technology segment accounted ...
(Date:9/22/2014)... , Sept. 22, 2014  Olympus, a ... solutions for medical and surgical procedures, among other ... deal with Munich -based Brainlab ... ® Navigation. This agreement applies to the ... cross-disciplinary U.S. sales and all distribution outside the ...
(Date:9/22/2014)... 22, 2014  Sutro Biopharma today announced that it ... of 2014,s Fierce 15 biotechnology companies, designating it as ... the industry.  "Sutro has earned some ... well as industry partners for what promises to be ... says John Carroll , editor of FierceBiotech ...
Breaking Medicine Technology:Global Ablation Technologies (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, Microwave) Market - Forecasts to 2019 2Global Ablation Technologies (Radiofrequency, Ultrasound, Irreversible Electroporation, Cryotherapy, Microwave) Market - Forecasts to 2019 3Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 2Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 3Olympus Partners with Brainlab as Exclusive Distributor for ENT Products in U.S. Market 4FierceBiotech names Sutro Biopharma as one of its "Fierce 15" Biotech Companies of 2014 2FierceBiotech names Sutro Biopharma as one of its "Fierce 15" Biotech Companies of 2014 3
... the "NEXT" Study Also Showed Arzoxifene Significantly Suppressed ... with OsteoporosisATHENS, Greece, March 23 Eli Lilly ... new data showing arzoxifene, an investigational selective estrogen ... increasing bone mineral density (BMD) in the lumbar ...
... Santaris Pharma announced today that,the fourth LNA-based drug ... USA,several patients with cancer have now been treated ... by Santaris Pharma and Enzon,Pharmaceuticals. The U.S. Food ... New Drug (IND) application,for the use of the ...
Cached Medicine Technology:Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 2Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 3Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 4Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis 5Another LNA-based RNA Inhibitor Enters Clinical Trials 2Another LNA-based RNA Inhibitor Enters Clinical Trials 3
(Date:9/22/2014)... News) -- Teens and young adults at risk for ... help prevent risky sexual behaviors, according to new recommendations ... year, about 20 million new sexually transmitted infections such ... About half involve people between 15 and 24 years ... new report, published Sept. 22 in Annals of ...
(Date:9/22/2014)... pulls back the curtain on one of the most ... income between physicians who perform operations, procedures or tests, ... the research indicates, the physician payment system is not ... , The new findings counter the widely held belief ... why doctors who perform procedures often earn nearly twice ...
(Date:9/22/2014)... Manhattan residents who suffer with hip ... hip , which could be bursitis now have a ... now offered at New York Dynamic Neuromuscular Rehabilitation Center. ... occurs when the trochanteric bursa becomes irritated or inflamed. ... between the iliotibial band and the greater trochanter. Most ...
(Date:9/22/2014)... Steven Reinberg HealthDay Reporter ... urging that all children aged 6 months and older be ... of Pediatrics updated their influenza vaccine recommendations to advise that ... to build immunity. The AAP also wants parents of children ... nasal spray vaccine instead of the flu shot if it,s ...
(Date:9/22/2014)... 40 percent of patients undergoing breast cancer surgery require ... the cancerous tissue in the initial operation. However, researchers ... a tool they developed that will help surgeons better ... the chances for repeat operations. , ... 22, 2014 in the Proceedings of the National ...
Breaking Medicine News(10 mins):Health News:Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs 2Health News:Behavioral Counseling Urged for Teens, Young Adults at Risk for STDs 3Health News:Think the system for paying US doctors is rigged to favor surgeons? Study may surprise you 2Health News:Think the system for paying US doctors is rigged to favor surgeons? Study may surprise you 3Health News:Think the system for paying US doctors is rigged to favor surgeons? Study may surprise you 4Health News:DNR Clinic Offers Hip Bursitis Treatment in Manhattan 2Health News:DNR Clinic Offers Hip Bursitis Treatment in Manhattan 3Health News:Pediatricians Urge Flu Vaccine for All Kids 6 Months and Older 2Health News:Pediatricians Urge Flu Vaccine for All Kids 6 Months and Older 3Health News:The fine line between breast cancer and normal tissues 2
... In India the only laboratory equipped to handle the avian ... Tiny vials of chicken blood and poultry tissue arrive each ... by the farmers from places that experience unusual chicken deaths ... Hare Krishna Pradhan, who heads the High Security Animal Disease ...
... always pleasurable to the eye and so are coloured veggies ... led by Dr. Isabelle Romieu of the National Institute of ... women consuming plenty of tomatoes, carrots and leafy greens appear ... per a report in the medical journal Thorax. Still, it's ...
... insomnia or loss of sleep affects finding way around negatively. ... is difficulty finding the way around.// ,This was tried ... rats' spatial memory was affected. ,Still, experts at UK ... the Journal of Neurophysiology. ,Two groups of rats were studied, ...
... Speculation that the Food and Drug Administration will give ... shares in ViroPharma to dip by about 33 percent. ... after Laura Alvey, a spokeswoman for the F.D.A said ... revised the bioequivalence recommendations for oral vancomycin from a ...
... are angry at the village heads, which has issued orders ... threatened to go on an indefinite strike unless the order ... directed district chief medical officers to take the attendance of ... the help of village chiefs or other local officials. ...
... is recovering well, after a cancer unit administered a potentially ... life, and is currently receiving specialist oxygen treatment. // She ... soon. ,Lisa Norris from Girvan in Ayrshire, ... overdose 17 times at the Beatson Oncology Centre in Glasgow. ...
Cached Medicine News:
Designed to meet the requirements of reagent grade water for routine analysis....
... L/min of Type I ultrapure water, , ... Plus System is designed to provide the ... pretreated by reverse osmosis, distillation or deionization. ... quality which exceeds Type I ASTM/CAP/NCCLS specifications.,The ...
... Basic Laboratory Needs, Synergy systems produce ultrapure water ... 1 to 1.2 L/min to meet the basic ... incorporates a dual-wavelength UV lamp (185 nm and ... of organic contaminants (< 5 ppb TOC when ...
... Compact System Produces Type I Water Directly from ... designed for scientists who need 5 to 15 ... not have easy access to acceptable quality pretreated ... 0.6 L/min of ultrapure (Type I) water on ...
Medicine Products: