Navigation Links
Tioga Pharmaceuticals' Asimadoline Demonstrates Positive Results in a Phase 2b Clinical Trial for the Treatment of Irritable Bowel Syndrome
Date:5/20/2008

ed. Patients underwent a two-week screening, a 12-week treatment and a four-week follow-up period, and they received identical appearing placebo, 0.15 mg, 0.5 mg or 1.0 mg tablets of asimadoline twice daily for the treatment period. Throughout the trial, patients entered data daily by IVRS (interactive voice response system). The primary endpoint was number of months a patient was a responder for adequate relief of pain, where the primary measure was the question, "In the past 7 days have you had adequate relief of your IBS pain or discomfort?" asked once every 7 days. A monthly responder replied "yes" at least three weeks per month. The secondary endpoints were abdominal pain, stool frequency and consistency, urgency, bloating, adequate relief of IBS symptoms and straining. Secondary endpoints were also collected using IVRS. Adverse events, labs and echocardiograms were also collected.

About Irritable Bowel Syndrome

Irritable bowel syndrome is a common, chronic gastrointestinal disorder characterized by abdominal pain and discomfort associated with alterations in bowel habits. The bowel abnormalities may manifest as diarrhea-predominant disease, constipation-predominant disease, or alternation between diarrhea and constipation. IBS is estimated to afflict approximately 12 percent of the adult population in the United States and Europe, with roughly equal prevalence of each subtype. For reasons that remain unknown, IBS is a female-predominant disorder, with two-thirds to three-quarters of the subjects being female.

Lotronex (alosetron), a selective 5-HT3 receptor antagonist, is the only drug currently approved by the FDA for the treatment of D-IBS; however, due to safety concerns, Lotronex was removed from the market in 2001 and re-launched in 2002 under a strict risk management program. No treatment is currently approved by the FDA for A-IBS. There is, therefore, an urgent unmet clinical need for a safe and effective treatment for the 20 millio
'/>"/>

SOURCE Tioga Pharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
2. Vion Pharmaceuticals Completes Accrual of 85 Patients to its Pivotal Phase II Trial of Cloretazine(R) (VNP40101M) in Elderly AML
3. Solvay Pharmaceuticals, Inc. and Wyeth Pharmaceuticals Announce Receipt of an FDA Action Letter for Bifeprunox, an Investigational Treatment for Schizophrenia
4. Callisto Pharmaceuticals Opens Additional Sites for Phase II Clinical Trial of Atiprimod in Advanced Carcinoid Cancer Patients
5. WallSt.net (www.wallst.net) Updates the Investment Community Through an All-New Interview With RegeneRx Biopharmaceuticals CEO
6. Quark Pharmaceuticals, Inc. Presented Positive Preclinical Results of Systemic RNAi Compound for Acute Renal Failure (ARF)
7. Peregrine Pharmaceuticals Doses First Patient in Cotara(R) Phase II Brain Cancer Trial In India
8. Nabi Biopharmaceuticals Announces Second Quarter 2007 Financial Results
9. Access Pharmaceuticals Provides Update on Clinical Development Plan of ProLindac
10. Quark Pharmaceuticals Extends Research Agreement with State University of New York for Proprietary siRNA Compounds for Acute Hearing Loss
11. Acura Pharmaceuticals, Inc. Secures Financing to Fund Pivotal Phase III Clinical Trial for Lead Aversion(R) Technology Product Candidate
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... March 27, 2015 As of February, ... incontinence devices for women. "Shipping thousands ... gratifying part is the hundreds of letters, emails ... lives have been positively impacted by our technology," ... InControl recently released Apex, an over-the-counter ...
(Date:3/27/2015)... Mass. , March 27, 2015 /PRNewswire/ ... and privately-held MirImmune LLC, today announced that ... agreement to RXi,s novel and proprietary sd-rxRNA® ... cancer immunotherapies. The collaboration has the potential ... patient friendly cancer treatments that could be ...
(Date:3/27/2015)...  Delcath Systems, Inc. (NASDAQ: DCTH ), ... on oncology with an emphasis on the treatment ... reporting of data from a single -center experience ... the Delcath Hepatic Delivery System (Melphalan/HDS) and other ... of Surgical Oncology (SSO) Annual Meeting 2015.  The ...
Breaking Medicine Technology:InControl Medical Surpasses 40,000 Shipments Of Incontinence Devices For Women 2RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 2RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 3RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 4RXi Pharmaceuticals and MirImmune LLC Enter into an Exclusive Licensing Agreement for RXi's Self-Delivering RNAi (sd-rxRNA) Technology to Develop Cell-based Immunotherapies to Treat Cancer 5Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 2Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 3Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 4Data Highlighting Delcath's Melphalan/HDS Presented At The Society Of Surgical Oncology Annual Meeting 5
... 9 Avinger, Inc., a medical device company ... combat peripheral artery disease, announces the enrollment of ... OcclusioN CrossiNg with thE WildCat CatheTer) clinical trial. ... study intended to evaluate the Wildcat Catheter,s ability ...
... (Nasdaq: PCYC ), a biopharmaceutical company focused ... the treatment of cancer and mediated diseases, today announced ... fiscal quarter and fiscal year ended June 30, 2010 ... 2010.  The company will conduct a conference call and ...
Cached Medicine Technology:First Patient Enrolled in 'CONNECT' Clinical Trial 2Pharmacyclics Announces Date of Fiscal Year End 2010 Financial Results and Conference Call and Presentation at Stifel Nicolaus Healthcare Conference 2
(Date:3/29/2015)... Aliso Viejo, California (PRWEB) March 29, 2015 ... have revealed a new transition from Pixel Film Studios, ... 12 sports transitions made exclusively for Final Cut Pro ... “We’ve given our users the tools needed to effortlessly ... Film Studios introduces TranSports, a new and uniquely styled ...
(Date:3/29/2015)... 2015 “Health is an endo thing, ... learn more about the cannabinoid system … we learn ... Publius’ Go Endo-Cannabinoid Update ~ new on the ... celebrated. Publius, of The Cannabis Papers: A citizen’s guide ... Health (PubMed) cannabinoid system (CS) articles discussing: cannabinoids in ...
(Date:3/28/2015)... (PRWEB) March 28, 2015 Coffee could not ... help protect you from gum disease, researchers have found. , ... gum disease. , Coffee contains antioxidants. Antioxidants fight gum disease. ... question researchers at Boston Univ. Henry M. Goldman School of ... the August 2014 issue of the Journal of Periodontology. , ...
(Date:3/28/2015)... "Necrorun" was featured on NewsWatch as part of its ... and coolest applications on the market for iOS, Android, ... technology expert, conducted the app review and shared with ... with knights, nature, and peasants. , The first ... Eurogamer. The popularity of these games grew over the ...
(Date:3/28/2015)... 2015 With more than 4,500 ... of osteoporosis, osteoarthritis and musculoskeletal diseases gathered here ... be the first time in the 17-year history ... the hot-button topic is an emerging non-pharmaceutical protocol ... scientific principles of Wolff’s law, osteogenic loading at ...
Breaking Medicine News(10 mins):Health News:Introducing TranSports for Final Cut Pro X Users from Pixel Film Studios 2Health News:March Homeostasis: Publius’ Go Endo-Cannabinoid Update ~ New on the Bryan William Brickner Blog 2Health News:New Research Impliments Coffee May Help Fight Gum Disease and Increasing Benefits With Tylers Coffee 2Health News:A Grim Endless Runner Game Was Featured on NewsWatch Television on January 30, 2015 2Health News:Non-Drug Protocol for Building Bone Density Expected to Steal Spotlight at World Congress on Osteoporosis 2
... ... for pets and their owners, without a safety system in place.,Pets Guardian Emergency Notification ... or other unforeseen event., , ... (PRWEB) July 2, 2010 -- With vacation time here and the economic ...
... Parents ... that their child has a healthy diet, particularly those from wealthier families. Yet, in describing ... or cutting out snacks, junk food and takeaways. , ... (PRWEB) July 4, 2010 -- According to a recent survey, ...
... ... HealthCare Professionals (IAHCP) welcomes esteemed psychiatrist Dr. Lyubov Gorelik into the pages thier exclusive ... New York State as a leader in psychiatry, and will be featured alongside other ... ...
... , ... , and skin care brand, Bellaboo, today released its short documentary clip on teen self esteem ... esteem. , ... One Girl At A Time is giving a voice to the number one issue ...
... ... 2020 America will be in the midst of an allergy and asthma crisis. , ... Phoenix, AZ (Vocus) July 2, 2010 -- DrFinders ... indicates that by the year 2020 there will be such a severe shortage of Allergists that ...
... All ... , ... 2, 2010 -- There’s growing consumer awareness and concern in the U.S. and abroad about ... (July 2010), European food and beverage manufacturers will be required to include a strong warning ...
Cached Medicine News:Health News:Pets Guardian Provides A Pet Safety System, Ensuring Pets Will Be Cared For In Case of a Personal Emergency 2Health News:Pets Guardian Provides A Pet Safety System, Ensuring Pets Will Be Cared For In Case of a Personal Emergency 3Health News:Parents Overestimate Children's Diets as Healthy 2Health News:Parents Overestimate Children's Diets as Healthy 3Health News:Parents Overestimate Children's Diets as Healthy 4Health News:Renowned Psychiatrist, Lyubov Y Gorelik, M.D., is selected to represent New York in The Leading Physicians of the World 2Health News:Bellaboo Releases One Girl At A Time Documentary 2Health News:DrFinders Cites a Study Indicating that by the Year 2020 America will be in the Midst of an Allergy and Asthma Crisis 2Health News:Surf Sweets Among Few Candy Offerings Free of Synthetic Dyes Despite Growing Consumer Concern Over Affect on Children 2Health News:Surf Sweets Among Few Candy Offerings Free of Synthetic Dyes Despite Growing Consumer Concern Over Affect on Children 3Health News:Surf Sweets Among Few Candy Offerings Free of Synthetic Dyes Despite Growing Consumer Concern Over Affect on Children 4
Offers the dual convenience of resecting tissue while simultaneously evacuating through a suction channel in the instrument....
Smith & Nephew ACUFEX scissors are constructed without pins for maximum strength, dependability, durability, and safety.,A wide range of tips and angles enable the surgeon to effectively dissect any ...
The most traditional style of instrument, a classical punch shape with the parrot beak upper jaw to aid in the capture of tissue....
This family of punches offers the best of both worlds the lowest profile and the largest bite, facilitating end-on and lateral cutting the most versatile instrument available....
Medicine Products: