Navigation Links
Tiny Cup Attached to Eye Improves Drug Delivery For Retinal Diseases
Date:8/7/2009

this kind of device on any organ and the ability to deliver medication to the affected organ, could be a huge advance in how we currently treat cancer," Dr. Murphree said. This work is done in conjunction with Ricardo Carvalho, M.D., Ph.D. and the company 3T Ophthalmics which is developing the drug delivery system.

The episcleral drug reservoir is inserted under the thin, filmy conjunctiva, or covering of the eyeball, to the sclera -- the fibrous, protective outer layer of the eye. The tiny cup administers the drug slowly by passive diffusion through the sclera, where it reaches the retina and vitreous. The device is so small the patient should feel little or no discomfort and it does not hinder normal vision.

Currently, drugs for most retinal diseases are delivered either through an I.V. drip (i.e. systemically) or by an injection into the eyeball (i.e. intravitreal), both of which pose risks for the patient.

For example, chemotherapy for retinoblastoma, a cancer affecting one in 15,000 children, must now be given intravenously. This requires relatively large doses of the drug are needed to achieve a therapeutic concentration in the retina. The chemotherapy destroys the bone marrow and depresses the child's immune system, often leading to secondary infections.

Intravitreal injections using a syringe, often used to treat age-related macular degeneration, require frequent out-patient visits and can lead to vitreous hemorrhage and retinal detachment. Eye drops are also generally ineffective for retinal diseases because most medications are washed away or diluted before they have a chance to reach the retina, located at the back of the eye close to the brain.

"When we administer chemotherapy to an infant for retinoblastoma at The Vision Center, it is expensive and puts a great strain on the family, especially if they are from another state. Our preliminary research shows that
'/>"/>

SOURCE Children's Hospital Los Angeles
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Rigels R788 Significantly Improves Rheumatoid Arthritis in Phase 2b Clinical Trial
2. Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia
3. FYI From Human Genome Sciences: GlaxoSmithKline Study Shows GSKs Novel Diabetes Treatment Syncria(R) (Albiglutide) Improves Glucose Control, Reduces Weight
4. Heparin Use Prior to Endoscopic Vein Harvest Improves Graft Patency in Off-Pump Coronary Artery Bypass Patients
5. Study Shows GSKs Novel Diabetes Treatment SYNCRIA(R) (albiglutide) Improves Glucose Control and Reduces Weight
6. Back to Normal: Surgery Improves Outcomes for Spine Patients
7. New Research Shows Nutrition 21s Chromium Histidinate Improves Markers for Mood and Carbohydrate Cravings
8. New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure
9. Program Improves Language Skills in Deaf, Hard of Hearing
10. Brain Training Improves Memory and Attention and the Effects Last
11. Rexin-G Controls Tumor Growth and Improves Survival in Chemotherapy-Resistant Soft Tissue Sarcoma and Osteosarcoma: Phase I/II & Confirmatory Phase II Studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... PISCATAWAY, New Jersey , July ... Crystallographic Data Centre (CCDC) celebrates 50 years of ... Symposium and the launch of new software in ... (WebCSD) to the world,s most comprehensive collection of ... visualisations, intermolecular interaction analysis, geometry analysis, and support ...
(Date:6/30/2015)... -- Velos, Inc., the pioneering software company for clinical ... customers who receive Clinical and Translational Science Awards ("CTSAs").  ... the National Institutes of Health currently use Velos software ... largest such market shares in its product class.  ... growing as a result of our continued intense focus ...
(Date:6/30/2015)... June 30, 2015   Millar, Inc. , a ... announced the 2016 retirement of Craig Thummel , ... 12 years of service to the Company. The Company ... senior members of the Executive Management team as his ... Daugherty , currently Director of Sales and Marketing, as ...
Breaking Medicine Technology:Scientific Symposium and New Software for Crystallographers and Scientists Worldwide to Celebrate 50 Years of the Cambridge Structural Database 2Scientific Symposium and New Software for Crystallographers and Scientists Worldwide to Celebrate 50 Years of the Cambridge Structural Database 3Velos continues adding CTSA customers - 40% now use Velos products 2Millar, Inc. Announces Leadership Changes 2Millar, Inc. Announces Leadership Changes 3
... Uncovers New Link Between Inflammation & Alzheimer,s Disease , ... 16 The Roskamp Institute today announced that its ... Alzheimer,s disease and have identified a potential target for ... The study, led by Roskamp Institute,s Pancham Bakshi, Ph.D., ...
... Celtic Pharmaceutical Holdings L.P. ("Celtic Pharma") announced today that ... the two double-blinded studies of XERECEPT (R) (corticorelin acetate), ... an initial database lock on the open-label study of XERECEPT,s ... The results of these studies are the subject of ...
Cached Medicine Technology:Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease 2Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease 3Celtic Pharma Announces Update on Status of XERECEPT(R) Program Sale Planned in 2009 2
(Date:7/1/2015)... ... July 01, 2015 , ... The executive ... and marketing of a number of nutritional and beauty products, announced the company ... ECRM Diet, Vitamin & Sports Nutrition conference in Tampa, Florida. This specific ECRM ...
(Date:7/1/2015)... ... 01, 2015 , ... Nutritional Products International, a brand focused on the global ... the 2015 ECRM Diet, Vitamin & Sports Nutrition conference in Tampa, Florida, where it ... ECRM trade show allows companies the chance to meet with a variety of the ...
(Date:7/1/2015)... NV (PRWEB) , ... July 01, 2015 , ... ... be showcasing the newly launched Patient Self-Management (PSM) Solutions at the Society for ... that has been in use for over 10 years, can reduce overall cost ...
(Date:6/30/2015)... ... 01, 2015 , ... Avid boxing style rock concert poster collector, Andrew Hawley ... posters. The Who and the Rascals also played at this concert in New York ... played with the Who backing them up. The Doors gave a very stirring performance ...
(Date:6/30/2015)... ... July 01, 2015 , ... ... responsive and easy to navigate. By making fundamental changes to the UI, the ... from the site said, “Finding the right website has been getting tougher. People ...
Breaking Medicine News(10 mins):Health News:NPI Executives Report Great Success at ECRM Conference 2Health News:NPI Meets With Top Retail Figures at ECRM Conference 2Health News:APhA Foundation to Showcase Newly Introduced Patient Self-Management Solutions at the Society for Human Resource Management (SHRM) Annual Conference and Exposition 2Health News:Avid Boxing Style Rock Concert Poster Collector From Vintage Rock Posters Announces Search for 1968 Doors and Jimi Hendrix Singer Bowl Concert Posters 2Health News:HerpesDatingSites.org Introduces a New Responsive Design 2
... MONDAY, Nov. 15 (HealthDay News) -- People who wear multifocal ... who wear glasses, a new study finds. Multifocal lenses ... common with age. This study included 11 volunteers, aged ... track at night. Wearing multifocal contact lenses resulted ...
... on gaming and health in adolescents, conducted by researchers ... differences linked to gaming as well as important health ... journal Pediatrics , the study is among the ... gaming and problematic gaming in a community sample of ...
... is approximately 40 percent and show no sign of ... to tackle the problem using a comprehensive and pioneering ... partnerships with the Cleveland Metropolitan School District (CMSD) and ... National Institutes of Health (NIH)-funded program will be led ...
... world,s first remote heart procedure, using a robotic arm alongside ... in Leicester. It comes six months after Dr ... procedure using the Amigo Robotic Catheter System. Dr ... consultant cardiologist and electrophysiologist at Glenfield Hospital. On ...
... , MONDAY, Nov. 15 (HealthDay News) -- Although automated external ... in public places such as restaurants, malls and airplanes, they ... of death when used in hospitals, a new study suggests. ... of heart rhythms associated with the heart attack, said researchers ...
... with the cardiac diagnostic imaging technique of myocardial perfusion imaging ... high cumulative estimated radiation dose, according to a study in ... is being released early online because it is being presented ... medical imaging has grown rapidly in recent years, but along ...
Cached Medicine News:Health News:When video games get problematic so do smoking, drug use and aggression 2Health News:Community rallies to fight obesity in Cleveland's urban youth 2Health News:Community rallies to fight obesity in Cleveland's urban youth 3Health News:Community rallies to fight obesity in Cleveland's urban youth 4Health News:Robo-op marks new world first for heart procedure 2Health News:External Defibrillators Not Much Help in Hospitals 2Health News:External Defibrillators Not Much Help in Hospitals 3Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 2Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 3
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
SOLOS Endoscopy shares your commitment to provide every patient with the highest quality care available through our ongoing research and development of advanced surgical instruments and diagnostic so...
Operate with confidence. Autosuture is advancing the sate of both open and minimally invasive surgery by providing surgical tools that feel right, function right, and facilitate the right outcome eve...
Medicine Products: