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Tigris Pharmaceuticals Initiates Randomized Phase 2 Study of AFP-464 in ER-Positive Breast Cancer Patients
Date:5/26/2011

with ER positive metastatic disease."

About AFP-464

AFP-464 is a novel anti-cancer agent currently being studied by Tigris Pharmaceuticals in a randomized Phase 2 clinical trial with ER-positive breast cancer patients.  AFP-464 is also being studied by the National Cancer Institute ("NCI") under a Cooperative Research and Development Agreement (CRADA). NCI is sponsoring two  Phase 1 clinical trials in patients with solid tumors under the CRADA. Pre-clinical studies into AFP-464's mechanism of action have shown that AFP-464 is converted to metabolites, which bind covalently to DNA, resulting in p53 activation and apoptosis. AFP-464 has shown a unique pattern of growth inhibitory activity in the NCI's 60 tumor cell line screen, with breast, ovarian, lung and renal tumor cell lines exhibiting particular sensitivity to the compound. In vivo anti-tumor activity of AFP-464 has been demonstrated in several xenograft studies in mice bearing renal and breast cancer. Pre-clinical studies have shown that tumors (breast, ovarian, pancreatic and renal) with AhR localized in the cytoplasm are very sensitive to AFP-464 while those with AhR localized in the nucleus are more resistant.

About Tigris Pharmaceuticals, Inc.

Tigris Pharmaceuticals, Inc. is a privately held biopharmaceutical company that acquires, develops and commercializes innovative specialty care therapies to treat oncology, pain, inflammation, acute and supportive care areas of unmet medical need. Tigris' mission is to efficiently move its existing and future technologies through the various stages of clinical development in order to meet patients' needs for safe and effective treatments of human illnesses.

Contacts:

Alexander Mironov
Vice President of Operations
Tigris Pharmaceuticals, Inc.
(239) 444-5400
info@tigrispharma.com

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