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Tibotec Presents Interim Findings for TMC435, an Investigational Genotype 1 Hepatitis C Treatment, at the AASLD Liver Meeting 2008
Date:11/1/2008

cluding HCV, HIV and tuberculosis."

About the Phase IIa Study

Investigators in five European countries assessed the antiviral activity, safety, and pharmacokinetics of two once-daily regimens of TMC435 (25 mg or 75 mg TMC435 versus placebo) in fifty HCV genotype 1 treatment-naive patients in an ongoing double-blind, placebo-controlled phase IIa trial. Patients were randomized to receive either seven days of monotherapy with TMC435 or placebo followed by 21 days of triple therapy with TMC435 or placebo, plus PegIFNalpha-2a (180 mcg once weekly) and RBV (1000-1200 mg daily); or, 28 days of triple therapy with TMC435 or placebo, plus PegIFNalpha-2a and RBV. After day 28, patients continue on PegIFNalpha-2a/RBV alone for a total of 24 or 48 weeks at the discretion of the investigator.

TMC435 data from other studies will also be presented at the AASLD Liver Meeting.

About HCV

According to the Centers for Disease Control and Prevention (CDC), about 3.2 million people in the United States are infected with chronic HCV and 19,000 people are newly infected each year.(4) Chronic infection with HCV can lead to cirrhosis and liver cancer, and is the most common cause of liver transplant in the United States.(4,5)

About Tibotec BVBA

Tibotec BVBA is a global pharmaceutical and research development company. The company's main research and development facilities are in Mechelen, Belgium with offices in Yardley, Pa. and Cork, Ireland. Tibotec is dedicated to the discovery and development of innovative HIV/AIDS and hepatitis C drugs, and anti-infectives for diseases of high unmet medical need.

Forward Looking Statement

This press release contains "forward-looking statements" as defined in the Private Securities Litigation Reform Act of 1995. These statements are based on current expectations of future events. If underlying assumptions prove inaccurate or unknown risks or uncertainties materialize, actual results could var
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SOURCE Tibotec BVBA
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