Navigation Links
Tibotec Presents Interim Findings for TMC435, an Investigational Genotype 1 Hepatitis C Treatment, at the AASLD Liver Meeting 2008
Date:11/1/2008

Nearly 90 percent of patients achieve undetectable viral load in Phase IIa trial within 28 days of combined treatment with standard of care

SAN FRANCISCO, Nov. 1 /PRNewswire/ -- New clinical data show antiviral activity of TMC435, an investigational protease inhibitor (PI) being developed by Tibotec BVBA for the treatment of chronic hepatitis C virus (HCV) infection. Tibotec will present findings from three TMC435 studies, including a late-breaker poster on the proof-of-principle phase IIa trial, OPERA-1 (TMC435-C201), at the American Association for the Study of Liver Disease's (AASLD) Liver Meeting 2008 in San Francisco.

The current standard of care treatment for HCV infection, pegylated interferon (Peg-IFN) combined with ribavirin (RBV), is effective in 30 to 50 percent of patients infected with chronic genotype 1 HCV infection, the most common type in the United States.(1) The development of new therapies and strategies for treating HCV, particularly the introduction of direct antivirals, may offer patients a new option with shorter treatment duration.(2,3)

TMC435 Phase IIa Study Results

In interim findings from the first 28 days of treatment for the first cohort of fifty (50) treatment naive HCV+, genotype 1, patients (once daily dose of 25 mg or 75 mg TMC435 versus placebo), both doses showed dose-dependent antiviral activity. TMC435 was administered in combination with PegIFNalpha-2a/RBV (triple therapy) for 28 days or as monotherapy for seven days and, thereafter, in combination with PegIFNalpha-2a/RBV (triple therapy) for three weeks. There were neither serious adverse events, nor grade 3 or 4 adverse events, related to TMC435 or any safety-related treatment discontinuations during this 28 day treatment period.

The most common adverse events associated with TMC435 were nausea, diarrhea, and headache. There were no clinically relevant changes in laboratory parameters, ECGs, or vital signs. Steady-state plasma trough
'/>"/>

SOURCE Tibotec BVBA
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. AHF Criticizes Tibotec Over Steep Price for Newest AIDS Drug, Etravirine
2. Tibotec Conducts Two Pivotal Phase III Clinical Trials Studying TMC278 in Treatment-Naive Adults with HIV
3. Ninety-Six Week Data on Tibotec Investigational NNRTI, TMC278, Presented at AIDS 2008
4. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
5. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
6. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
7. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
8. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
9. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
10. Targanta Presents First Data Demonstrating In Vitro Activity and In Vivo Efficacy of Prodrugs in Osteomyelitis Models
11. Wyeth Presents Phase 3 Fracture Data for Bazedoxifene, an Investigational Therapy for Osteoporosis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... , July 11, 2014  Kindred Hospital Houston ... announce the opening of its new outpatient wound ... services to people with chronic, hard to heal ... can lead to amputation, lower leg wounds related ... delayed closure, and traumatic injury wounds which are ...
(Date:7/11/2014)... Australia , July 11, 2014  Australian drug ... announced that it has raised A$19.3 million via a ... Europe , the U.S., Asia ... A$3 million from a share purchase plan (SPP) to ... million will be made in two tranches. ...
(Date:7/11/2014)... , July 11, 2014 ... 4,396.20, down 0.52%, the Dow Jones Industrial Average finished the ... at 1,964.68, down 0.41%. The losses were broad based as ... The S&P 500 Health Care Sector Index ended the day ... in the last one month. Investor-Edge has initiated coverage on ...
Breaking Medicine Technology:Kindred Hospital Houston Northwest, With Wound Care Specialists, Opens Outpatient Wound Healing And Hyperbaric Center 2Phosphagenics' A$19.3 million Capital Raising 2Phosphagenics' A$19.3 million Capital Raising 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 2Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 3Health Care Equipment Equities Movers and Shakers -- Research on Covidien, Baxter, DexCom, and Boston Scientific 4
(Date:7/11/2014)... (PRWEB) July 11, 2014 Ticket Down is a ... in Mountain View, CA. Over the years Luke Bryan ... accolades. Not only does he do well at award shows, but ... of the most anticipated tours of the genre and this summer ... few artists can compare to the popularity and success that is ...
(Date:7/11/2014)... Ticket Down is a reliable ... Train Amphitheatre in Wheatland, CA. In the Sacramento ... what the Sleep Train Amphitheatre can do for music fans. ... over the course of its existence and can seat 18,500 ... in Wheatland (Sacramento metro area) will host the “That’s My ...
(Date:7/11/2014)... Riverside Health System became the first provider of ... late 2012 and now, in partnership with Williamsburg Landing, will ... Williamsburg and Newport News region. , Also known as life ... independent older adults who wish to remain in their homes ... continuing care services as well as control over the cost ...
(Date:7/11/2014)... Austin, TX (PRWEB) July 11, 2014 ... to their staff. Jim Siddons joins the agency as ... Siddons graduated in 1994 with a Bachelor’s Degree in ... years of industry experience and will manage everything from ... bonds for trucking to the specialized needs for those ...
(Date:7/11/2014)... 2014 Europe is one of the ... cultivated-and hence, irrigated land area. The agricultural sector is ... for around 30.0% of the total water use. The ... the southern region, but far from negligible in most ... for over 60.0% of the water use in most ...
Breaking Medicine News(10 mins):Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 2Health News:Luke Bryan Tickets Shoreline Amphitheatre in Mountain View, CA: Ticket Down Slashes Ticket Prices for Luke Bryan in Mountain View at the Shoreline Amphitheatre 3Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 2Health News:Luke Bryan Tickets Sleep Train Amphitheatre in Wheatland, CA (Sacramento): Ticket Down has Slashed Ticket Prices on Luke Bryan in Wheatland at Sleep Train 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 2Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 3Health News:Riverside and Williamsburg Landing Partner to Offer First of Its Kind Service to Virginians Who Want to Age in Place 4Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3
... bedside patient safety solutions -SAN DIEGO, April 3 ... handheld barcode point-of-care (BPOC) solutions ... Sweeney has been appointed Chairman and CEO.(Logo: ... CEO of eight healthcare service companies including Bridge ...
... boost strength in other ways, researchers say , , FRIDAY, April ... mass in octogenarian women but still helped them lift more ... University in Indiana finds. , , The six ... for three months on a machine designed to strengthen the ...
... F C, s * ... , Although recent media attention has focused on the presence of ... Protection Agency and the U.S. Food and Drug Administration (FDA) have ... appropriate for all consumers, including sensitive sub-populations like infants. Trace ...
... Inc. (Nasdaq: MEDQ ) has announced it has ... of Sales and Marketing. Gold will be responsible for ... of MedQuist. "We are pleased to have Alan join the ... brings an extensive knowledge and an in-depth understanding of healthcare ...
... poorer scores on cognitive tests , , FRIDAY, April 3 (HealthDay News) ... life span may be taking a toll on the brains of ... shows that women aged 47 to 74 who tested positive for ... or bones (an indication of cumulative exposure over the life span) ...
... & Spa,Group, Inc. (OTC Bulletin Board: SOKF) announced the ... April 1, 2009. The latest SOKO Spa began,offering "pre-opening" ... more,than 500 Spa members since that date. , ... Blessing Hot Spring Business Club,No.332, Xinyang Rd., Daoli District, ...
Cached Medicine News:Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 2Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 3Health News:James M. Sweeney Named Chairman and CEO of IntelliDOT 4Health News:Muscle Mass Won't Grow in Women Over 80 2Health News:International Formula Council (IFC) Reassures Parents about Perchlorate and the Safety of Infant Formula 2Health News:MedQuist Names Alan J. Gold as Senior Vice President, Sales and Marketing 2Health News:Accumulated Lead May Affect Older Women's Brains 2Health News:SOKO Fitness & Spa Group, Inc. Opens Xinyang Spa in Harbin 2
... UniBloc weighing mechanism for speed, ... stability control, analog display modes, multiple ... percent measure functions, auto print, and ... data from built-in clock. Built-in, ...
TOPLOAD 320/0.01G, BL320S. Touch-key external calibration only. Requires calibration weights (either 200g or 300g). 120/240V A/C adapter, Lock-down Ring, In-use Protective Cover....
... - Battery Powered (6 size AA required). ... (g, ct, oz, ozt, GN, dwt, mom, ... and Percent Measure functions, Auto Print. Optional ... AC adapter may be ordered for AC ...
... (6 size AA required). Fast, Lightweight Strain ... ozt, GN, dwt, mom, dwt, tael), Specific ... functions, Auto Print. Optional hook (321-34532-03) available ... be ordered for AC Operation of ELB. ...
Medicine Products: