Navigation Links
Tibotec Conducts Two Pivotal Phase III Clinical Trials Studying TMC278 in Treatment-Naive Adults with HIV
Date:7/17/2008

- Once-daily TMC278, the third anti-HIV compound to be developed in Tibotec

virology portfolio -

YARDLEY, Pa., July 17 /PRNewswire/ -- Tibotec Pharmaceuticals Ltd. announced today that two major phase III efficacy trials examining TMC278, its investigational non-nucleoside reverse transcriptase inhibitor (NNRTI), in treatment-naive adults with HIV-1, are now recruiting patients. The global trials will compare the efficacy, safety and tolerability of TMC278 (25 mg) once daily oral tablet versus efavirenz (EFV), each coadministered with a background regimen of two nucleoside/nucleotide reverse transcriptase inhibitors (N[t]RTIs), in treatment-naive HIV-1-infected adults.

"Preliminary data have shown TMC278 to be active against HIV for patients who have not previously received treatment," Roger Pomerantz, MD, President of Tibotec Research and Development. "These phase III studies will provide important information on the safety and efficacy of this potential new treatment."

The first phase III, double-blind, randomized study, known as TMC278-C209 or ECHO (Efficacy Comparison in treatment-naive HIV-infected subjects Of TMC278 and EFV), will evaluate TMC278 (25 mg) once daily oral tablet versus EFV (600 mg) once daily, when combined with a fixed background regimen consisting of emtricitabine + tenofovir disoproxil fumarate. A second phase III, double-blind randomized study, known as TMC278-C215 or THRIVE (TMC278 against HIV, in a once daily RegImen Versus Efavirenz), will evaluate TMC278 (25 mg) once daily versus EFV (600 mg) once daily, when combined with an investigator-selected background regimen consisting of two N[t]RTIs (abacavir + lamivudine or tenofovir disoproxil fumarate + emtricitabine or zidovudine + lamivudine).

Each study will be conducted at more than 100 sites in over 20 countries, including the U.S., Canada and several countries in Latin America, among others, and will seek to enroll approximat
'/>"/>

SOURCE Tibotec Pharmaceuticals Ltd.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. AHF Criticizes Tibotec Over Steep Price for Newest AIDS Drug, Etravirine
2. Maine Natural Health Company Conducts Dental Clinical Trial
3. Biodel Inc. Announces the Completion of Its Two Pivotal Trials and the Release of EASD Abstracts Containing Additional Interim Data From Its VIAject(TM) Program
4. Isolagen Completes Pivotal Efficacy Portion of Phase III Studies of Isolagen Therapy(TM) for Wrinkles
5. Terumo Heart Obtains IRB Approval from the University of Michigan to Initiate DuraHeart(TM) Left Ventricular Assist System U.S. Pivotal Trial
6. Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease
7. Victory Pharma, Inc. Reports MGX006 Enters Into Pivotal Development Program
8. European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals
9. Medivation Initiates Second Pivotal Phase 3 Trial of Dimebon(TM) in Patients With Alzheimers Disease
10. Nephros Completes Pivotal U.S. Clinical Trial for its Hemodiafiltration Products
11. Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytrens Contracture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... , Sept. 19, 2014 The Parenteral Drug ... harmonize global post-approval changes protocols. The ... the topic expressed by industry participants and regulatory authority ... this month in Washington, DC . ... on hand for the workshop. Attendees indicated openness to ...
(Date:9/19/2014)... 19, 2014 /PRNewswire-iReach/ -- "United States ... provides key market data on the ... The report provides value, in millions ... units) within market categories – Bronchoscopes, ... & Gastroscopes, Duodenoscopes, Laparoscopes, Hysteroscopes, Sinuscopes, ...
(Date:9/19/2014)... , Sept. 19, 2014  The board of ... declared a quarterly cash dividend of $0.42 per share.  ... 17, 2014 to stockholders of record at the close ... AbbVie AbbVie is a global, research-based biopharmaceutical company formed ... is to use its expertise, dedicated people and unique ...
Breaking Medicine Technology:PDA Launches Effort to Harmonize Global Post-Approval Changes Protocols 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 5
... 31, 2011 Reportlinker.com announces that a ... its catalogue: Germany Surgical ... http://www.reportlinker.com/p0254518/Germany-Surgical-Equipment-Market-Outlook-to-2016.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Surgical_Equipment Germany ... Summary GlobalData,s ...
... Pacira Pharmaceuticals, Inc. (Nasdaq: PCRX ), an ... the third quarter ended September 30, 2011 and provided ... (FDA) approval of EXPAREL™ (bupivacaine liposome injectable suspension) and ... "With the broad postsurgical pain management label granted ...
Cached Medicine Technology:Germany Surgical Equipment Market Outlook to 2016 2Germany Surgical Equipment Market Outlook to 2016 3Germany Surgical Equipment Market Outlook to 2016 4Germany Surgical Equipment Market Outlook to 2016 5Germany Surgical Equipment Market Outlook to 2016 6Germany Surgical Equipment Market Outlook to 2016 7Germany Surgical Equipment Market Outlook to 2016 8Germany Surgical Equipment Market Outlook to 2016 9Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 2Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 3Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 4Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 5Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 6Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 7Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 8Pacira Pharmaceuticals, Inc. Reports Third Quarter 2011 Financial Results 9
(Date:9/20/2014)... 2014 “Motherhood is a wonderful gift and ... their latest article , “We know that you want ... that’s what we want to do as well.” , The ... should expect from their Family Physicians who practice obstetrics while ... motherhood. , To learn more about Community Health Center ...
(Date:9/20/2014)... The children of Branches now have a new ... need. An empty lot at the Trish and Dan ... into a kid-designed playspace in less than eight hours ... ESPN (@TeamESPN), Disney (@CitizenDisney), area residents and organizers from ... more than a playground. It’s a brain-expander, friend-maker, and ...
(Date:9/19/2014)... York, NY (PRWEB) September 20, 2014 ... moderate revenue growth for the Vision Insurance industry ... pace, to the detriment of industry margins. From ... noticeably increase. Industry operators provide coverage for routine ... discounted pricing for eyeglasses, contact lens and refractive ...
(Date:9/19/2014)... 2014 Are you tired of having ... with seasonal allergies or sinus congestion? Fortunately, an inventor ... , She conceived of Nose Pal to avoid ... nose in public. Since it prevents nasal drip and ... conditions, particularly when cooking or working closely with others. ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 BearCom, ... solutions, today detailed the key role played by ... radios in the healthcare industry. , “In ... patient care – and in emergency situations, can ... between life and death,” said Hugh Johnston, Product ...
Breaking Medicine News(10 mins):Health News:Newest Article from Community Health Center of Snohomish County Highlights The Importance of Proper Health Care for Expectant Mothers 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 3Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 4Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Nasal Drip Eliminator Invented by InventHelp Client (LCC-218) 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 3Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 4
... Personal Protective Equipment Conference 2009 (PPE 2009), which ... in Fort Lauderdale, FL, November 17 - 19, 2009, ... networking resource for firefighters, law enforcement officers, military personnel, ... technicians, veterinary specialists, rescue team members, and other first ...
... , , ... supporting breast cancer research and awareness programs, Hard Rock International ... )winner, breast cancer survivor and multi-platinum recording artist, as its ... PINKTOBER program will also be ...
... , , Atlanta to Serve as ... NEW YORK , Sept. 14 ... the Center for AIDS Research at Emory University (CFAR) in Atlanta, Georgia will ... global scientific conference focused on AIDS vaccine research. AIDS 2010 is to ...
... for Down syndrome on the horizon promising to be safer, ... medical community must come together and engage in dialogue about ... leading article published Online First by Archives of Disease ... genetics fellow at Children,s Hospital Boston, the article shows a ...
... SXC Health Solutions Corp. ("SXC" or the "Company") (NASDAQ: ... has entered into a strategic relationship with Allscripts (NASDAQ: ... (e-prescribing) options available to SXC,s healthcare benefits management customers. ... plans, employers, government agencies, pharmacy benefit managers and pharmacies ...
... Sept. 14 A call for participants has been issued in ... upon the work the IMIA started in the 1980s with the ... final written exam pilot in support of national certification. , ... and rating of test items have been finalized, it is important ...
Cached Medicine News:Health News:Personal Protective Equipment Conference Set for November 17 - 19 in Fort Lauderdale 2Health News:Hard Rock International Marks 10 Years Of Support For Breast Cancer Awareness And Research With 2009 PINKTOBER(TM) Campaign Featuring Melissa Etheridge, The Bangles, Melanie C, Joss Stone And More 2Health News:Hard Rock International Marks 10 Years Of Support For Breast Cancer Awareness And Research With 2009 PINKTOBER(TM) Campaign Featuring Melissa Etheridge, The Bangles, Melanie C, Joss Stone And More 3Health News:Hard Rock International Marks 10 Years Of Support For Breast Cancer Awareness And Research With 2009 PINKTOBER(TM) Campaign Featuring Melissa Etheridge, The Bangles, Melanie C, Joss Stone And More 4Health News:Center for AIDS Research at Emory University to Serve as Local Host of AIDS Vaccine 2010 2Health News:Center for AIDS Research at Emory University to Serve as Local Host of AIDS Vaccine 2010 3Health News:Center for AIDS Research at Emory University to Serve as Local Host of AIDS Vaccine 2010 4Health News:Understanding the implications of prenatal testing for Down syndrome 2Health News:SXC Health Solutions teams with Allscripts to deliver critical prescription information to physicians at the point-of-care 2Health News:SXC Health Solutions teams with Allscripts to deliver critical prescription information to physicians at the point-of-care 3Health News:SXC Health Solutions teams with Allscripts to deliver critical prescription information to physicians at the point-of-care 4Health News:SXC Health Solutions teams with Allscripts to deliver critical prescription information to physicians at the point-of-care 5Health News:National Certification for Medical Interpreters - Public Call for Final Written Pilot Exam 2
... immersion objective has a higher numerical aperture ... media helps eliminate surface,reflections and provides an ... excellent objective for fluorescence, brightfield and DIC ... correction collar that allows it to be ...
... is a very versatile light source ... variety of applications anytime a Zeiss ... illumination with optimum protection without heating ... most economical cold-light source that completes ...
... a complete line of ... halogen light sources that ... A solid-state dimmer provides ... our exclusive Modulamp assembly ...
Standard 20x long working distance objectives for greater magnifications of your microtools....
Medicine Products: