Navigation Links
Tibotec Conducts Two Pivotal Phase III Clinical Trials Studying TMC278 in Treatment-Naive Adults with HIV
Date:7/17/2008

- Once-daily TMC278, the third anti-HIV compound to be developed in Tibotec

virology portfolio -

YARDLEY, Pa., July 17 /PRNewswire/ -- Tibotec Pharmaceuticals Ltd. announced today that two major phase III efficacy trials examining TMC278, its investigational non-nucleoside reverse transcriptase inhibitor (NNRTI), in treatment-naive adults with HIV-1, are now recruiting patients. The global trials will compare the efficacy, safety and tolerability of TMC278 (25 mg) once daily oral tablet versus efavirenz (EFV), each coadministered with a background regimen of two nucleoside/nucleotide reverse transcriptase inhibitors (N[t]RTIs), in treatment-naive HIV-1-infected adults.

"Preliminary data have shown TMC278 to be active against HIV for patients who have not previously received treatment," Roger Pomerantz, MD, President of Tibotec Research and Development. "These phase III studies will provide important information on the safety and efficacy of this potential new treatment."

The first phase III, double-blind, randomized study, known as TMC278-C209 or ECHO (Efficacy Comparison in treatment-naive HIV-infected subjects Of TMC278 and EFV), will evaluate TMC278 (25 mg) once daily oral tablet versus EFV (600 mg) once daily, when combined with a fixed background regimen consisting of emtricitabine + tenofovir disoproxil fumarate. A second phase III, double-blind randomized study, known as TMC278-C215 or THRIVE (TMC278 against HIV, in a once daily RegImen Versus Efavirenz), will evaluate TMC278 (25 mg) once daily versus EFV (600 mg) once daily, when combined with an investigator-selected background regimen consisting of two N[t]RTIs (abacavir + lamivudine or tenofovir disoproxil fumarate + emtricitabine or zidovudine + lamivudine).

Each study will be conducted at more than 100 sites in over 20 countries, including the U.S., Canada and several countries in Latin America, among others, and will seek to enroll approximat
'/>"/>

SOURCE Tibotec Pharmaceuticals Ltd.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. AHF Criticizes Tibotec Over Steep Price for Newest AIDS Drug, Etravirine
2. Maine Natural Health Company Conducts Dental Clinical Trial
3. Biodel Inc. Announces the Completion of Its Two Pivotal Trials and the Release of EASD Abstracts Containing Additional Interim Data From Its VIAject(TM) Program
4. Isolagen Completes Pivotal Efficacy Portion of Phase III Studies of Isolagen Therapy(TM) for Wrinkles
5. Terumo Heart Obtains IRB Approval from the University of Michigan to Initiate DuraHeart(TM) Left Ventricular Assist System U.S. Pivotal Trial
6. Pivotal Pulmonary Arterial Hypertension Study Published in The Lancet Concludes That Bosentan (Tracleer(R)) Demonstrates Benefits in Patients With Mildly Symptomatic WHO Functional Class II Disease
7. Victory Pharma, Inc. Reports MGX006 Enters Into Pivotal Development Program
8. European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals
9. Medivation Initiates Second Pivotal Phase 3 Trial of Dimebon(TM) in Patients With Alzheimers Disease
10. Nephros Completes Pivotal U.S. Clinical Trial for its Hemodiafiltration Products
11. Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytrens Contracture
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... 2014 Echo Therapeutics, Inc. (NASDAQ: ... on skin permeation, continuous glucose monitoring and associated ... has been appointed Chief Executive Officer effective ... 20 years of experience in the medical device, ... served as Vice President, Business Development, Otsuka Pharmaceuticals as ...
(Date:12/24/2014)... -- ResMed (NYSE: RMD ) today announced its ... device manufacturer BMC Medical Co., Ltd. The ... below infringe ResMed,s patents, and entered an order prohibiting BMC ... the United States : , iVolve nasal ... nasal pillows mask , iVolve full face mask ...
(Date:12/24/2014)... , Dec. 23, 2014   Synageva BioPharma ... biopharmaceutical company developing therapeutic products for rare disorders, ... (EMA) of the Marketing Authorization Application (MAA) for ... granted the company,s request for accelerated assessment, which ... review time.   The MAA, and ...
Breaking Medicine Technology:Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 2Echo Therapeutics Announces Scott W. Hollander as President & Chief Executive Officer 3ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
... Covance Inc. (NYSE: CVD ) said ... repurchase of up to $250 million of its outstanding ... approximately 800,000 shares remaining under the repurchase authorization announced ... the Company,s common stock. Any purchases under this buyback ...
... announces that a new market research report ... Diagnostic Imaging Equipment - Emerging Markets ... – 2015". http://www.reportlinker.com/p0304719/Diagnostic-Imaging-Equipment---Emerging-Markets-BRIC--Brazil- ... for diagnostic imaging equipment in Brazil, Russia, ...
Cached Medicine Technology:Covance Board Authorizes $250 Million Stock Buyback 2Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 2Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 3Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 4Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 5Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 6Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 7Reportlinker Adds Diagnostic Imaging Equipment - Emerging Markets (BRIC- Brazil, Russia, India, and China) 2010 - 2015". 8
(Date:12/26/2014)... (PRWEB) December 26, 2014 Pentec Health, ... in the state of Pennsylvania for 2014. The awards ... statewide programs of its kind in the country. The ... the Pennsylvania Department of Community and Economic Development, the ... Management and the Central Penn Business Journal. ...
(Date:12/25/2014)... The click strand woven bamboo ... durability. Today, the business announces a click strand ... Jan. 30, 2015. , Click strand woven bamboo ... is a well-known brand in the bamboo industry. ... a reliable bamboo flooring supplier. , “We are ...
(Date:12/25/2014)... Recently, iFitDress.com, the popular online supplier of wedding dresses ... selection of black one-shoulder cocktail dresses . In addition, ... available at discounted prices, up to 70% off. ... three weeks only. You know, we have thousands of frequent ... our new items can visit our website for more details. ...
(Date:12/25/2014)... California (PRWEB) December 25, 2014 Helen ... home in Woodland Hills, California after an 8 year ... away on Christmas Eve evening in her home in ... aggressive metastatic breast cancer. , As ... over forty years, she pioneered and championed many of ...
(Date:12/25/2014)... Dec. 25, 2014 (HealthDay News) -- Overeating is common during ... eat in moderation, an expert says. "Don,t arrive at ... calories if you know you,ll be attending a party, but ... Ashbey-Pejoves, lead dietitian at Northern Westchester Hospital in Mount Kisco, ... to eat healthy during the day and even to have ...
Breaking Medicine News(10 mins):Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 2Health News:Pentec Health Ranks Fourteenth on The Best Places to Work in PA for 2014 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:iFitDress.com: Black One-Shoulder Cocktail Dresses for 2015 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 2Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 3Health News:RP International founder, Helen Harris Dies on Christmas Eve Just Hours Before Her Holiday Television Broadcast to Raise Funds to Cure Blindness was Broadcasted Nationally 4
... especially ethnic and racial minorities, could get transplants, study ... umbilical cord blood transplant from an unrelated or unmatched ... as cancer and sickle cell anemia, Duke University Medical ... blood may be easier to obtain than adult bone ...
... Feb. 13 Symmetry Medical Inc. (NYSE: SMA ... orthopedic device industry and other medical markets, announced today that ... L. Hite, Senior Vice President and Chief Financial Officer, are ... the University of Nevada, Las Vegas on Tuesday, ...
... product line, including VETORYL(R) Capsules, now availableGLEN ... the nation,s largest practice-to-home delivery provider of ... announced an affiliation with Dechra Veterinary Products. ... expand its reach to veterinarians and pet ...
... Inc., will announce 2008 fourth quarter financial results on ... has been scheduled at 11 a.m., EST, for the ... In this call, representatives of US Oncology,s management team ... found on the company,s Web site, www.usoncology.co ...
... developed and tested a synthetic atherosclerosis drug that can ... producing the side-effect of fatty liver disease (which leads ... encouraging results of this study in mice could lead ... even prevent atherosclerosis. , Targets of this drug, called ...
... Professionals Meet on Expanding their Combination Products Research and Partnerships ... ... Needham, MA (PRWEB) February 13, 2009 -- ... recently posted details for its next executive forum - Combination ...
Cached Medicine News:Health News:Even Mismatched Cord Blood Can Help Kids 2Health News:VetCentric Partners with Dechra Veterinary Products 2Health News:Combination Products Executive Forum to be Hosted by CHI's Pharmaceutical Strategy Series 2Health News:Combination Products Executive Forum to be Hosted by CHI's Pharmaceutical Strategy Series 3
Near point card/newspaper 8 to 48 point type 5 1/2" X 8"....
Rosenbaum card fits in the pocket (3.5 by 6.5") and shows point, Jaeger and distance equivalents from 20/800 to 20/20. Uses numbers, directional Es and XO patterns. For use at 14" (35 mm). Includes f...
Standard reading test. "Value, care for..."...
Standard reading test. "Clearing weather..."...
Medicine Products: